In higher (multicellular) organisms, many processes are required for coordinating individual cells to act as parts of the whole. Among these we may count attraction of spermatozoides by ovum, environment sensing in general, cellular response to hormones and neuro transmitters, initiating and terminating cells multiplication, or imposing apoptosis on unneeded cells during ontogenesis.

Usually, Signal-Transduction would begin with binding of the singnal-molecule to a receptor on the cell-membrane, altering its configuration and thus starting a chain of reactions within the cell. These reactions may include (de)acetylations, (de)/phosphorilations on the participating molcules.

The Signal Transduction related reagents may by further classified as

  • Ca++-ATPase inhibitors, such as Artemisinin, Cyclopiazonic acid, Thapsigargin, Paxilline
  • SERCA Ca2+-ATPase stimulator/ activator, such as Ochratoxin A
  • Hedgehog signalling inhibitors: Cyclopamine

 

KT5555 (Lestaurtinib)

KT5555 (Lestaurtinib)
Molecular Formula
C26H21N3O4
M.W.
439.50
CAS number
111358-88-4
Source
Semisynthetic
Fermentek product Code
LES-001
Brand/grade
For research
Appearance
White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
233°C-243°C
Solubility test
Clear colorless solution at 20mg/ml DMSO
Names and identifiers

IUPAC/Chemical name:  (5S,6S,8R)-6-hydroxy-6-(hydroxymethyl)-5-methyl-7,8,14,15-tetrahydro-5H-16-oxa-4b,8a,14-triaza-5,8-methanodibenzo[b,h]cycloocta[jkl]cyclopenta[e]-as-indacen-13(6H)-one

Synonyms

  • KT5555
  • Lestaurtinib

 

 

Description

KT5555 is a multi targeted tyrosine kinase inhibitor.

InChl Key
UIARLYUEJFELEN-LROUJFHJSA-N
Canonical SMILES
CC12C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)(CO)O
Isomeric SMILES
C[C@@]12[C@](C[C@@H](O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)(CO)O
Compound Classification

Chemical classification

  • Indole alcaloids - Carbazoles - Staurosporine-derivates

Bioactivity classification

  • Enzyme inhibitors
  • Proteine kinase inhibitors / Tyrosine kinase inhibitors
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from light !
Use the original container to store the product.
Keep the lid tightly closed.
Store under argon.
Retest time
3 Years
Applications

It is used for the treatment of pancreatic cancer and acute myelogenous leukaemia (AML).

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Semi-Synthetic
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Not hazardous for transport
Title
CN code
Value
29349990
Title
CN code
Value
NO!!!
Title
inert gas storage
Value
after merck, TRC, carbosynth
Fermentek Product Category
Antibiotics
Research field: Cancer
Protein kinase related
Research field: Signal Transduction
Others
Signal to sort
K

Quote for

Price
$1.00
Lestaurtinib__KT5555_.gif
Lestaurtinib__KT5555_.gif

Fumonisin B3

Fumonisin B3
Molecular Formula
C34H59NO14
M.W.
705.80
CAS number
1422359-85-0
MSDS
Source
Fusarium moniliforme
Fermentek product Code
FB3-001
Brand/grade
For research
Appearance
White to slight yellow powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless solution 5 mg/ml Methanol
Names and identifiers
  • IUPAC Name:  2-[2-[(5R,6R,7S,9S,11R,18R,19S)-19-amino-6-(3,4-dicarboxybutanoyloxy)-11,18-dihydroxy-5,9-dimethylicosan-7-yl]oxy-2-oxoethyl]butanedioic acid
  • RTECS  TZ8340000
EU number
812-040-3
Description

A carcinogenic mycotoxin. An inhibitor of sphingosine biosynthesis

InChl Key
CPCRJSQNWHCGOP-KUHXKYQKSA-N
Canonical SMILES
CCCCC(C)C(C(CC(C)CC(CCCCCCC(C(C)N)O)O)OC(=O)CC(CC(=O)O)C(=O)O)OC(=O)CC(CC(=O)O)C(=O)O
Isomeric SMILES
CCCC[C@@H](C)[C@H]([C@H](C[C@@H](C)C[C@@H](CCCCCC[C@H]([C@H](C)N)O)O)OC(=O)CC(CC(=O)O)C(=O)O)OC(=O)CC(CC(=O)O)C(=O)O
Solubility ( literature )

Slightly soluble in water. Soluble in Methanol, Acetonitril. Insoluble in Chloroform, Petrol Ether, Hexane.

Compound Classification
  • Isoflavonoid
  • Phytoestrogen.
  • Sphingosine acyl-transterase inhibitor
Storage, handling
Protect from light
Retest time
3 Years
Disclaimer
Refer to MSDS for further safety and handling instructions.
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Not hazardous for transport
Title
Additional safety info
Value
GHS Hazards, EU Regulation 1272/2008, US OSHA 1910.1200) Not hazardous
Title
deleted CAS number
Value
136379-59-4
Fermentek Product Category
Food Safety
Mycotoxins
Food Safety Related
Cancer Related Compounds
Research field: Signal Transduction
Signal to sort
F

Quote for

Price
$1.00
Fumonisin_B3.gif
Fumonisin_B3.gif

Tunicamycin (complex)

Tunicamycin (complex)
Molecular Formula
C39H64N4O16 (for n=10, "Tunicamycin VII")
CAS number
11089-65-9
MSDS
Source
Streptomyces chartreusis
Fermentek product Code
TUN-001
Brand/grade
For research
Appearance
Off white to tan powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
4 spots matching standard, no other spots, by multiple methods.
Melting point
≥210°C
Solubility test
Clear solution at 5mg/ml of Methanol,
Clear solution at 50mg/ml of DMSO
Names and identifiers

RTECS: YO7980200

EU number
601-012-4
Description

Tunicamycin is a mixture of homologous nucleoside antibiotics.
The main homologs differ in the length of the fatty chain moiety.
The following table defines the four main Tunicamycin homologs.

  • Tunicamycin A, aka Tunicamycin V, n=9, mw=817;
  • Tunicamycin B, aka Tunicamycin VII, n=10, mw=831;
  • Tunicamycin C, aka Tunicamycin II, n=8, mw=845;
  • Tunicamycin D, aka Tunicamycin X, n=11, mw=859
Solubility ( literature )
  • Tunicamycin is soluble in DMSO, alkaline water, hot methanol.
  • Practically insoluble in acetone, ethyl acetate.
  • Unstable in acidic solutions
Compound Classification
  • nucleoside antibiotic
  • antiviral
  • inhibitor of glucosylation of proteins
  • tunicamycin causes cell cycle arrest in G1 phase
  • Tunicamycin has anti-angiogenesis properties.
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from moisture
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Applications

Tunicamycins inhibit protein glycosylation. They arrest cell cycle in late G1As Tunicamycin affects cell membrane permeability, it was shown to increase production of antibiotics, such as streptomycin PRODUCT USE A tool to study glycoprotein synthesis in a wide variety of biological systems. Family of nucleoside antibiotics produced by Streptomyces lysosuperificus. Tunicamycin interferes with glycoprotein synthesis in yeast and mammalian systems and enhances antiviral and anticellular activity of interferon. Possesses cell - surface altering activity. Inhibits the transfer of N-acetylglucosamine-1-phosphate from UDP -N- acetylglucosamine to dolichol monophosphate and thereby blocks the formation of N-glycosidic protein-carbohydrate linkages. Active in vitro against Gram-positive bacteria, yeasts, fungi and viruses.

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Pg II
Title
Deleted CAS Registry Numbers
Value
11118-26-6
Fermentek Product Category
Antibiotics
Enzyme-inhibitors
Research field: Cancer
Angiogenesis related
Protein kinase related
Anti Bacterial
Anti Viral
Research field: Signal Transduction
Signal to sort
T

Quote for

Price
$1.00

Thiostrepton

Thiostrepton
Molecular Formula
C72H85N19O18S5
M.W.
1 664.89
CAS number
1393-48-2
MSDS
Source
Streptomyces laurentii
Fermentek product Code
TIS-001
Brand/grade
For research
Appearance
White to off-white powder
slightly yellowish cast may be observed on the solid.
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
>210°C (decomposition, not melting.)
Solubility test
Clear colorless solution at 5mg/ml DMSO or Chloroform
Names and identifiers

Synonyms:  Alaninamide, Bryamycin , Thiactin
RTECS      :   XN6300100

EU number
215-734-9
Description

Thiostrepton is a broad spectrum polypeptide antibiotic which targets a wide range of gram positive and gram negative bacteria.

InChl Key
NSFFHOGKXHRQEW-DVRIZHICSA-N
Canonical SMILES
CCC(C)C1C(=O)NC(C(=O)NC(=C)C(=O)NC(C(=O)NC23CCC(=NC2C4=CSC(=N4)C(C(OC(=O)C5=NC6=C(C=CC(C6O)N1)C(=C5)C(C)O)C)NC(=O)C7=CSC(=N7)C(NC(=O)C8CSC(=N8)C(=CC)NC(=O)C(NC(=O)C9=CSC3=N9)C(C)O)C(C)(C(C)O)O)C1=NC(=CS1)C(=O)NC(=C)C(=O)NC(=C)C(=O)N)C)C
Isomeric SMILES
CCC(C)C1C(=O)NC(C(=O)NC(=C)C(=O)NC(C(=O)NC23CCC(=NC2C4=CSC(=N4)C(C(OC(=O)C5=NC6=C(C=CC(C6O)N1)C(=C5)C(C)O)C)NC(=O)C7=CSC(=N7)C(NC(=O)C8CSC(=N8)/C(=C\C)/NC(=O)C(NC(=O)C9=CSC3=N9)C(C)O)C(C)(C(C)O)O)C1=NC(=CS1)C(=O)NC(=C)C(=O)NC(=C)C(=O)N)C)C
Solubility ( literature )

Thiostrepton is soluble in chloroform, dichloromethane, dioxane, pyridine, glacial acetic acid, DMF. Practically insoluble in water, the lower alcohols, nonpolar organic solvents, diluted aqeous acids or bases. It may be dissolved by methanolic acid or base, but with decomposition. Working solution of 1% in DMSO is unstable and should be freshly prepared and protected from light.

Compound Classification

Polypeptide antibiotic
Antimicrobial

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from moisture
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Applications

Thiostrepton is used as a reagent for both positive and negative selection of genes involved in nucleotide metabolism. Thiostrepton is highly active against gram-positive bacteria. In its crude form, Thiostrepton is used in veterinary medicine, in mastitis caused by gram-negative organisms and in dermatologic disorders. inhibits bacterial protein synthesis. Inhibits mRNA-tRNA translocation by GTPase elongation factor G (EF-G), EF-TU(GTP)-catalyzed aa-tRNA delivery and the activity of initiation factor 2 (IF-2).

As an antitumoragent Thiostrepton induces cell cycle arrest and apoptosis in breast cancer cells via downregulation of FOXM1 expression. Thiostrepton is a FoxM1 specific inhibitor.

Disclaimer
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Shipped at ambient temperature
Transport safety: Not Dangerous Goods; Not Regulated
Transport safety: not regulated.
Available since
Title
Change notif 23-Jule-2018
Value
Updated storage condition
Title
update 22-Jan-2019
Value
minor update, shipment conditions
Title
toxicity by RTECS
Value
LD50 oral mouse >1 gram/kg
Fermentek Product Category
Antibiotics
Research field: Cancer
Protein synthesis inhibitors
Anti Bacterial
Cancer Related Compounds
Research field: Signal Transduction
Signal to sort
T

Quote for

Price
$1.00
Thiostrepton.gif
Thiostrepton.gif

Staurosporine

Staurosporine
Molecular Formula
C28H26N4O3
M.W.
466.53
CAS number
62996-74-1
MSDS
Source
Streptomyces staurosporeus
Fermentek product Code
STA-001
Appearance
Off-white to light yellow powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
255°C-275°C
Solubility test
Clear colorless solution at 5mg/ml Ethyl Acetate,
Clear yellow solution at 25mg/ml DMSO
Names and identifiers

Synonyms:  Antibiotic AM 2282; 

RTECS: KD5084000   ;  attention: This RTECS record belongs to the Hydrochloride salt of Staurosporine, rather than the free base form.

EU number
613-127-7
Chemical name
Staurosporine
Description

Staurosporine is a cell permeable inhibitor of protein kinases, including protein kinase-C.   Inhibitor of nuclear factor kappa B kinase beta subunit.

InChl Key
HKSZLNNOFSGOKW-FYTWVXJKSA-N
Canonical SMILES
CC12C(C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)NC)OC
Isomeric SMILES
C[C@@]12[C@@H]([C@@H](C[C@@H](O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)NC)OC
Solubility ( literature )

DMSO, Methanol, Ethanol, Ethyl Acetate. Water insoluble

Compound Classification
  • Chemical classification: Indolocarbazole alkaloid
  • Bio-activity: PKC inhibitor
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Applications
  • Pharmacological tool to study signal transduction pathways, tyrosine phosphorylation and to induce apoptosis.
  • May participate in antigen-induced T-cell activation;
  • Affects Proto-oncogene serine/threonine-protein kinase Pim-1, T-cell-specific kinase, Tyrosine-protein kinase SYK, MAP kinase-activated protein kinase 2
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Shipped at ambient temperature
Shipped in PP / PE bottle.
Available since
Title
Transport information
Value
Not hazardous for transport
Title
Deleted CAS numbers
Value
109189-95-9
Title
Safety comments
Value
Others say it is cancerogen, explosive. We think, because theirs contains ligroyin.
Title
identity comments
Value
HCl salt thereof: C28-H26-N4-O3.Cl-H ; RTECS KD5084000;
Fermentek Product Category
Antibiotics
Enzyme-inhibitors
Research field: Cancer
Apoptosis related
Protein kinase related
Anti Fungal
Cancer Related Compounds
Anti Tumor agents
Research field: Signal Transduction
Signal to sort
S

Quote for

Price
$1.00
Staurosporine.gif
Staurosporine.gif

Stauprimide

Stauprimide
Molecular Formula
C35H28N4O4
M.W.
584.62
CAS number
154589-96-5
Source
Semisynthetic
Fermentek product Code
STP-001
Brand/grade
For research
Appearance
Yellow powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
230°C-237°C
Solubility test
Clear yellow solution at 10mg/ml of DMSO, Clear yellow solution at 5mg/ml of Methanol
Names and identifiers

chemical name:

N-Benzoyl-7-oxostaurosporine

 

Description

Promoter of stem cells differentiation;

InChl Key
MQCCJEYZKWZQHU-MPRCCEKMSA-N
Canonical SMILES
CC12C(C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)C(=O)NC6=O)N(C)C(=O)C9=CC=CC=C9)OC
Isomeric SMILES
C[C@@]12[C@@H]([C@@H](C[C@@H](O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)C(=O)NC6=O)N(C)C(=O)C9=CC=CC=C9)OC
Solubility ( literature )

Reportedly, Stauprimide is soluble in methanol, DMSO. Other sources mention ethanol (slightly), DMF, water (limited) and report 10% solutions in DMSO (100 mg/ml),

Compound Classification
  • Carbazole Antibiotic
  • Staurosporine derivative (from MeSH)
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend +2 to +8°C storage, room temperature, desication etc.
Retest time
3 Years
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Semi-Synthetic
Ingredient type
Fermentek product
Usually packed in amber-glass vials, 1 ml; capped with teflon lined plastic caps
Available since
Title
Transport information
Value
Not hazardous for transport
Fermentek Product Category
Research field: Cancer
Protein kinase related
Research field: Signal Transduction
Others
Signal to sort
S

Quote for

Price
$1.00
Stauprimide.gif
Stauprimide.gif

Sinefungin

Sinefungin
Molecular Formula
C15H23N7O5
M.W.
381.39
CAS number
58944-73-3
MSDS
Source
Streptomyces sp.
Fermentek product Code
SN
Brand/grade
For research
Appearance
White to yellow powder
Purity by HPLC
≥96% ; refer to CoA for more data
Purity By TLC
≥96% ; refer to CoA for more data
Solubility test
Clear colorless solution at 20mg/ml of water
Names and identifiers

Synonym:

RTECS: HE3140000

UPAC Name: (2S,5S)-2,5-diamino-6-[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]hexanoic acid

 

 
EU number
637-385-5
Description

Natural antibiotic containing adenine, sugar hydroxyl and amino groups; exhibiting Antifungal ,Antimalarial and Antiprotozoal properties.

InChl Key
LMXOHSDXUQEUSF-YECHIGJVSA-N
Canonical SMILES
C1=NC2=C(C(=N1)N)N=CN2C3C(C(C(O3)CC(CCC(C(=O)O)N)N)O)O
Isomeric SMILES
C1=NC2=C(C(=N1)N)N=CN2[C@H]3[C@@H]([C@@H]([C@H](O3)C[C@H](CC[C@@H](C(=O)O)N)N)O)O
Solubility ( literature )

Good water solubility. Soluble in ethanol, methanol, DMF or DMSO (lit.)

Compound Classification

Chemical class:

  • Adenosine analog
  • Nucleoside antibiotic

Biological activity:

  • Antifungal 
  • Antimalarial
  • Antiprotozoal

 

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from moisture
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Applications

Sinefungin derivatives as inhibitors and structure probes of protein lysine methyltransferase SETD2 Antifungal Antimalarials Antiprotozoal

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Not hazardous for transport
Title
toxicity by RTECS oral mouse LD50
Value
1 gram/kg
Fermentek Product Category
Antibiotics
Anti Protozoal
Anti Bacterial
Anti Viral
Research field: Signal Transduction
Signal to sort
S

Quote for

Price
$1.00
Sinefungin.gif
Sinefungin.gif

PKC412

PKC412 (Midostaurin)
Molecular Formula
C35H30N4O4
M.W.
570.60
CAS number
120685-11-2
Source
Synthetic
Fermentek product Code
PKC-001
Brand/grade
For research
Appearance
White to off-white powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
225°C-235°C
Solubility test
Clear colorless solution at 10mg/ml DMSO; Clear colorless solution at 5mg/ml methanol
Names and identifiers

Synonyms:

  • Midostaurin
  • PKC412
  • Benzoylstaurosporine
  • 4'-N-Benzoylstaurosporine

Commercial names: 

  • Rydapt

RTECS: CV5045180

Chemical name
4'-N-benzoyl staurosporine
Description

PKC412 (Midostaurin) is a cell permeable inhibitor of protein kinases, including protein kinase-C.

InChl Key
BMGQWWVMWDBQGC-UHFFFAOYSA-N
Canonical SMILES
CC12C(C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)N(C)C(=O)C9=CC=CC=C9)OC
Solubility ( literature )

Soluble in DMSO, Dichloromethane.
Water solubility : < 0.1 mg/1

Compound Classification
  • indolocarbazole alkaloid
  • PKC inhibitor
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Protect from moisture! Hygroscopic substance.
Retest time
3 Years
Applications
  • PKC412 is mentioned as a specific treatment for Myeloproliferative Disease (MPD)
  • PKC412 selectively inhibits protein kinase C (PKC)
  • Investigated for use/treatment in adult patients with high-risk acute myeloid leukemia (AML)
Disclaimer
Semi-Synthetic.
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Not hazardous for transport
Fermentek Product Category
Research field: Cancer
Angiogenesis related
Protein kinase related
Cancer Related Compounds
Research field: Signal Transduction
Others
Signal to sort
P

Quote for

Price
$1.00
PKC412__Midostaurin_.gif
PKC412__Midostaurin_.gif

Paxilline

Paxilline
Molecular Formula
C27H33NO4
M.W.
435.56
CAS number
57186-25-1
MSDS
Source
Penicillium paxilli
Fermentek product Code
PAX-001
Brand/grade
For research
Appearance
White crystalline powder
Purity by HPLC
≥97% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless solution at 100mg/ml DMSO; Clear colorless solution at 5mg/ml Acetone
Names and identifiers

*** Disambiguation: ***
Paxilline, a mycotoxin of penicillium origin, should not be confused with
Paxillin, a signal transducing adaptor protein involved in cell migration (MESH).

IUPAC name
(2R,​4bS,​6aS,​12bS,​12cR,​14aS)-​4b-​hydroxy-​2-​(1-​hydroxy-​1-​methylethyl)-​12b,​12c-​dimethyl-​5,​6,​6a,​7,​12,​12b,​12c,​13,​14,​14a-​decahydro-​2H-​chromeno​[5',6':​6,7]​indeno​[1,2-​b]​indol-​3(4bH)-​one

RTECS: DJ2830000

EU number
637-206-0
Description

Paxilline: a selective blocker of high-conductance Ca2+-activated (Maxi-K) potassium channels

InChl Key
ACNHBCIZLNNLRS-UBGQALKQSA-N
Canonical SMILES
CC12CCC3C(=CC(=O)C(O3)C(C)(C)O)C1(CCC4C2(C5=C(C4)C6=CC=CC=C6N5)C)O
Isomeric SMILES
C[C@]12CC[C@H]3C(=CC(=O)[C@H](O3)C(C)(C)O)[C@@]1(CC[C@@H]4[C@@]2(C5=C(C4)C6=CC=CC=C6N5)C)O
Solubility ( literature )

Acetone, Methanol, and DMSO.

Compound Classification
  • tremorgen mycotoxin
  • Potassium chanells blocker
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from light !
Store under argon.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Applications

Potassium channels blocker

Disclaimer
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Pg III
Fermentek Product Category
Mycotoxins
Tremorgens
Research field: Signal Transduction
Signal to sort
P

Quote for

Price
$1.00
Paxilline.gif
Paxilline.gif

Patulin

Patulin
Molecular Formula
C7H6O4
M.W.
154.10
CAS number
149-29-1
MSDS
Source
Penicillium expansum
Fermentek product Code
PAT-001
Brand/grade
For research
Appearance
White crystalline solid.
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
105°C-113°C
Solubility test
Clear colorless solution at 10mg/ml DMSO
Names and identifiers

Synonyms:

  • Clavacin
  • Claviformin
  • Mycoin
  • Penicidin
  • Expansin
  • Leucopin
  • Gigantin

IUPAC name: 4-hydroxy-4H-furo[3,2-c]pyran-2(6H)-one

HSDB: 3522

RTECS#: LV2625000

EU number
205-735-2
Description

Patulin: a cytostatic, antibacterial mycotoxin. Inhibits potassium uptake, activates the p38 kinase.

InChl Key
ZRWPUFFVAOMMNM-UHFFFAOYSA-N
Canonical SMILES
C1C=C2C(=CC(=O)O2)C(O1)O
Solubility ( literature )

Patulin is soluble in DMSO, Methanol, Ethanol, water

Compound Classification
  • Lactone Mycotoxin
  • Cell signaling reagent;
  • apopotosis inducer
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from light !
Retest time
3 Years
Applications

Patulin was suggested as a remedy against common cold and reached clinical trials step in 1943 in Great Britain. However Patulin was found to be inefficient as such.(International Journal of Epidemiology 2004;33:243–246)

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Pg II
Fermentek Product Category
Mycotoxins
Apoptosis related
Cancer Related Compounds
Anti Tumor agents
Research field: Signal Transduction
Signal to sort
P

Quote for

Price
$1.00
Patulin.gif
Patulin.gif
Subscribe to Research field: Signal Transduction