Cancer is most accurately described as a class of diseases characterized by uncontrolled cell growth and division.There are more than a hundred defined types of cancer.

Cancer can occur in nearly every organ or tissue in the body.

Various small molecules are widely used in the research of cancer. Especially in the last decade, cancer research has evolved from a one-size-fits-all approach that emphasized cytotoxic chemotherapy to a more personalized medical strategy that focuses on the discovery and development of targeted drugs.

These drugs are designed, on a molecular level, to exploit particular genetic dependencies, addictions, and vulnerabilities of cancer cells.

Much current cancer research is concentrated in the areas of programmed cell death, tumor invasion and angiogenesis, tumor immunology, oncogenic signaling, gene expression and copy number, epigenetic regulation, toxicity and chemoresistance, metabolic stress and damage to DNA. Fermentek offers more than 30 unique biochemicals currently being used in cancer research.

Dimethylamino Parthenolide (DMAPT)

Dimethylamino Parthenolide (DMAPT)
Molecular Formula
C17H27NO3
M.W.
293.40
CAS number
795195-09-7
Source
Synthetic
Fermentek product Code
DMP-001
Brand/grade
For research
Appearance
White crystalline solid.
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
145°C-153°C
Solubility test
Clear colorless solution at 10 mg/ml Ethanol or DMSO or Dichloromethane.
Description

DMAPT is water soluble semi-synthetic derivate of Parthenolide.

InChl Key
UJNSFDHVIBGEJZ-ONGJMVGKSA-N
Canonical SMILES
CC1=CCCC2(C(O2)C3C(CC1)C(C(=O)O3)CN(C)C)C
Isomeric SMILES
C/C/1=C\CC[C@@]2([C@@H](O2)[C@@H]3[C@@H](CC1)[C@@H](C(=O)O3)CN(C)C)C
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Use the original container to store the product.
Keep the lid tightly closed.
Avoid moisture.
Retest time
3 Years
Applications

DMAPT has been reported as antiviral, anti HIV, anti Hepatitis C virus

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Semi-Synthetic
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Not hazardous for transport
Fermentek Product Category
Research field: Cancer
Apoptosis related
Cancer Related Compounds
Research field: Inflamation
Others
Signal to sort
D

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Price
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Dimethylamino_Parthenolide.gif
Dimethylamino_Parthenolide.gif

Wortmannin

Wortmannin
Molecular Formula
C23H24O8
M.W.
428.44
CAS number
19545-26-7
Source
Talaromyces (Penicillium) wortmannii
Fermentek product Code
WOR-001
Brand/grade
For research
Appearance
White to slight yellow powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
230°C-240°C
Solubility test
Clear colorless to faint yellow solution at 5 mg/ml Methanol;
Clear colorless to faint yellow solution at 10mg/ml Ethyl Acetate;
Names and identifiers

Synonyms:

  • Wartmannin
  • Antibiotic SL-2052

Systematic Name:

  • (1alpha,11alpha)-11-(Acetyloxy)-1-(methoxymethyl)-2-oxaandrosta-5,8-dieno(6,5,4-bc)furan-3,7,17-trione

RTECS: CB641000

EU number
606-337-5
Chemical name
Wortmannin
Description

Wortmannin is a steroid metabolite of the fungus Talaromyces wortmannii. It is a specific covalent inhibitor of phosphoinositide 3-kinases. Wortmannin has been used as precursor of an experimental anti-cancer drug PX-866

InChl Key
QDLHCMPXEPAAMD-QAIWCSMKSA-N
Canonical SMILES
CC(=O)OC1CC2(C(CCC2=O)C3=C1C4(C(OC(=O)C5=COC(=C54)C3=O)COC)C)C
Isomeric SMILES
CC(=O)O[C@@H]1C[C@]2([C@@H](CCC2=O)C3=C1[C@]4([C@H](OC(=O)C5=COC(=C54)C3=O)COC)C)C
Solubility ( literature )

DMSO, Methanol.

Wortmannin is unstable in aqueous and ethanolic solutions.

Compound Classification
  • chemical class: Androstadiene.
  • phospholipase D inhibitor.
  • phosphatidylinositol 3-kinase inhibitor.
  • Immunosupressor.
  • Antifungal.
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Protect from moisture! Hygroscopic substance.
Retest time
3 Years
Applications

Wortmannin is an inhibitor of phosphatidyl-inositol 3-kinase Wortmannin inhibits the growth of mammary tumors despite the existence of a novel wortmannin-insensitive phosphatidylinositol-3-kinase. Wortmannin inhibits repair of DNA double-strand breaks in irradiated normal human cells. Wortmannin was shown to have enhancing influence on memory and impair learning abilities. .

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
Deleted CAS number:
Value
1405-03-4
Title
Transport information
Value
PG I
Fermentek Product Category
Enzyme-inhibitors
Research field: Cancer
Protein kinase related
Anti Fungal
Others
Signal to sort
W

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Wortmannin.gif
Wortmannin.gif

Virginiamycin S1

Virginiamycin S1
Molecular Formula
C43H49N7O10
M.W.
823.89
CAS number
23152-29-6
Source
Streptomyces virginiae
Fermentek product Code
VIS-001
Brand/grade
For research
Appearance
White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
222°C-235°C
Solubility test
Clear colorless solution at 5 mg/ml of Dichloromethane
Names and identifiers
  • Staphylomycin S
  • N-(3-Hydroxypicolinoyl)-L-threonyl-D-alpha-aminobutyryl-L- prolyl-N-methyl-L-phenylalanyl-4-oxo-L-pipecoloyl-L-2- phenylglycine rho-lactone
EU number
245-462-6
Description

Cyclic polypeptide antibiotic Virginiamycin S1 is a major component of virginiamycin complex, which is used in veterynary medicine to treat Gram-positive infections, and as a growth promoter in young swine and cattle. 

Virginiamycin is originated in Streptomyces virginiae, but also other strains of streptomycettes. Virginiamycin S1 is a cyclic polypeptide antibiotic, of Streptogramin group B class. Reportedly, it targets the 60S ribosomal protein L37 affecting translation, ribosomal structure. It binds to the 23S rRNA

InChl Key
FEPMHVLSLDOMQC-CPKGNLGUSA-N
Canonical SMILES
CCC1C(=O)N2CCCC2C(=O)N(C(C(=O)N3CCC(=O)CC3C(=O)NC(C(=O)OC(C(C(=O)N1)NC(=O)C4=C(C=CC=N4)O)C)C5=CC=CC=C5)CC6=CC=CC=C6)C
Isomeric SMILES
CC[C@H]1C(=O)N2CCC[C@@H]2C(=O)N([C@@H](C(=O)N3CCC(=O)C[C@H]3C(=O)N[C@H](C(=O)O[C@@H]([C@@H](C(=O)N1)NC(=O)C4=C(C=CC=N4)O)C)C5=CC=CC=C5)CC6=CC=CC=C6)C
Solubility ( literature )

Virginiamycin S1 is soluble in ethanol, methanol, DMSO, Dichloromethane, DMF, and sparingly, in water .

Compound Classification

Cyclic peptide antibiotic, Streptogramin group

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Retest time
3 Years
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Not hazardous for transport
Fermentek Product Category
Antibiotics
Research field: Cancer
Protein synthesis inhibitors
Signal to sort
V

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Price
$1.00
Virginiamycin_S1.gif
Virginiamycin_S1.gif

Tunicamycin (complex)

Tunicamycin (complex)
Molecular Formula
C39H64N4O16 (for n=10, "Tunicamycin VII")
CAS number
11089-65-9
MSDS
Source
Streptomyces chartreusis
Fermentek product Code
TUN-001
Brand/grade
For research
Appearance
Off white to tan powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
4 spots matching standard, no other spots, by multiple methods.
Melting point
233°C-245°C
Solubility test
Clear solution at 5mg/ml of Methanol,
Clear solution at 50mg/ml of DMSO
Names and identifiers

RTECS: YO7980200

EU number
601-012-4
Description

Tunicamycin is a mixture of homologous nucleoside antibiotics.
The main homologs differ in the length of the fatty chain moiety.
The following table defines the four main Tunicamycin homologs.

  • Tunicamycin A, aka Tunicamycin V, n=9, mw=817;
  • Tunicamycin B, aka Tunicamycin VII, n=10, mw=831;
  • Tunicamycin C, aka Tunicamycin II, n=8, mw=845;
  • Tunicamycin D, aka Tunicamycin X, n=11, mw=859
Solubility ( literature )
  • Tunicamycin is soluble in DMSO, alkaline water, hot methanol.
  • Practically insoluble in acetone, ethyl acetate.
  • Unstable in acidic solutions
Compound Classification
  • nucleoside antibiotic
  • antiviral
  • inhibitor of glucosylation of proteins
  • tunicamycin causes cell cycle arrest in G1 phase
  • Tunicamycin has anti-angiogenesis properties.
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from moisture
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Applications

Tunicamycins inhibit protein glycosylation. They arrest cell cycle in late G1As Tunicamycin affects cell membrane permeability, it was shown to increase production of antibiotics, such as streptomycin PRODUCT USE A tool to study glycoprotein synthesis in a wide variety of biological systems. Family of nucleoside antibiotics produced by Streptomyces lysosuperificus. Tunicamycin interferes with glycoprotein synthesis in yeast and mammalian systems and enhances antiviral and anticellular activity of interferon. Possesses cell - surface altering activity. Inhibits the transfer of N-acetylglucosamine-1-phosphate from UDP -N- acetylglucosamine to dolichol monophosphate and thereby blocks the formation of N-glycosidic protein-carbohydrate linkages. Active in vitro against Gram-positive bacteria, yeasts, fungi and viruses.

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Pg II
Title
Deleted CAS Registry Numbers
Value
11118-26-6
Fermentek Product Category
Antibiotics
Enzyme-inhibitors
Research field: Cancer
Angiogenesis related
Protein kinase related
Anti Bacterial
Anti Viral
Research field: Signal Transduction
Signal to sort
T

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Trichostatin A

Trichostatin A
Molecular Formula
C17H22N2O3
M.W.
302.37
CAS number
58880-19-6
Source
Streptomyces platensis
Fermentek product Code
TRA-001
Brand/grade
For research
Appearance
White to Off-White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
138°C-150°C
Solubility test
Clear colorless solution at 5mg/ml Methanol; Clear yellow solution at 20mg/ml DMSO
Names and identifiers

Synonyms:

  • 2,​4-​Heptadienamide, 7-​[4-​(dimethylamino)​phenyl]​-​N-​hydroxy-​4,​6-​dimethyl-​7-​oxo-​, (2E,​4E,​6R)​-
  • (2E,4E,6R)-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide
  • TSA
  • (R)-(+)-Trichostatin A

 

 

EU number
611-758-2
Description

Trichostatin A is an antifungal antibiotic.

Trichostatin A is a potent, reversible inhibitor of histone deacetylase (HDAC)

InChl Key
RTKIYFITIVXBLE-QEQCGCAPSA-N
Canonical SMILES
CC(C=C(C)C=CC(=O)NO)C(=O)C1=CC=C(C=C1)N(C)C
Isomeric SMILES
C[C@H](/C=C(\C)/C=C/C(=O)NO)C(=O)C1=CC=C(C=C1)N(C)C
Solubility ( literature )

DMSO, Ethanol

Compound Classification

HDAC inhibitor

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from moisture
Open carefully.
Use the original container to store the product.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Not hazardous for transport
Fermentek Product Category
Antibiotics
Enzyme-inhibitors
Research field: Cancer
Signal to sort
T

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Price
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Trichostatin_A.gif
Trichostatin_A.gif

Thiostrepton

Thiostrepton
Molecular Formula
C72H85N19O18S5
M.W.
1 664.89
CAS number
1393-48-2
MSDS
Source
Streptomyces laurentii
Fermentek product Code
TIS-001
Brand/grade
For research
Appearance
White to off-white powder
slightly yellowish cast may be observed on the solid.
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
>210°C (decomposition, not melting.)
Solubility test
Clear colorless solution at 5mg/ml DMSO or Chloroform
Names and identifiers

Synonyms:  Alaninamide, Bryamycin , Thiactin
RTECS      :   XN6300100

EU number
215-734-9
Description

Thiostrepton is a broad spectrum polypeptide antibiotic which targets a wide range of gram positive and gram negative bacteria.

InChl Key
NSFFHOGKXHRQEW-DVRIZHICSA-N
Canonical SMILES
CCC(C)C1C(=O)NC(C(=O)NC(=C)C(=O)NC(C(=O)NC23CCC(=NC2C4=CSC(=N4)C(C(OC(=O)C5=NC6=C(C=CC(C6O)N1)C(=C5)C(C)O)C)NC(=O)C7=CSC(=N7)C(NC(=O)C8CSC(=N8)C(=CC)NC(=O)C(NC(=O)C9=CSC3=N9)C(C)O)C(C)(C(C)O)O)C1=NC(=CS1)C(=O)NC(=C)C(=O)NC(=C)C(=O)N)C)C
Isomeric SMILES
CCC(C)C1C(=O)NC(C(=O)NC(=C)C(=O)NC(C(=O)NC23CCC(=NC2C4=CSC(=N4)C(C(OC(=O)C5=NC6=C(C=CC(C6O)N1)C(=C5)C(C)O)C)NC(=O)C7=CSC(=N7)C(NC(=O)C8CSC(=N8)/C(=C\C)/NC(=O)C(NC(=O)C9=CSC3=N9)C(C)O)C(C)(C(C)O)O)C1=NC(=CS1)C(=O)NC(=C)C(=O)NC(=C)C(=O)N)C)C
Solubility ( literature )

Thiostrepton is soluble in chloroform, dichloromethane, dioxane, pyridine, glacial acetic acid, DMF. Practically insoluble in water, the lower alcohols, nonpolar organic solvents, diluted aqeous acids or bases. It may be dissolved by methanolic acid or base, but with decomposition. Working solution of 1% in DMSO is unstable and should be freshly prepared and protected from light.

Compound Classification

Polypeptide antibiotic
Antimicrobial

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from moisture
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Applications

Thiostrepton is used as a reagent for both positive and negative selection of genes involved in nucleotide metabolism. Thiostrepton is highly active against gram-positive bacteria. In its crude form, Thiostrepton is used in veterinary medicine, in mastitis caused by gram-negative organisms and in dermatologic disorders. inhibits bacterial protein synthesis. Inhibits mRNA-tRNA translocation by GTPase elongation factor G (EF-G), EF-TU(GTP)-catalyzed aa-tRNA delivery and the activity of initiation factor 2 (IF-2).

As an antitumoragent Thiostrepton induces cell cycle arrest and apoptosis in breast cancer cells via downregulation of FOXM1 expression. Thiostrepton is a FoxM1 specific inhibitor.

Disclaimer
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Shipped at ambient temperature
Transport safety: Not Dangerous Goods; Not Regulated
Transport safety: not regulated.
Available since
Title
Change notif 23-Jule-2018
Value
Updated storage condition
Title
update 22-Jan-2019
Value
minor update, shipment conditions
Title
toxicity by RTECS
Value
LD50 oral mouse >1 gram/kg
Fermentek Product Category
Antibiotics
Research field: Cancer
Protein synthesis inhibitors
Anti Bacterial
Cancer Related Compounds
Research field: Signal Transduction
Signal to sort
T

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Thiostrepton.gif
Thiostrepton.gif

Tenuazonic acid (Cu salt)

Tenuazonic acid – Copper salt
Molecular Formula
C20H28CuN2O6
M.W.
455.99
CAS number
12427-40-6
Source
Alternaria sp.
Fermentek product Code
TNZ-001
Brand/grade
For research
Appearance
Light blue-greenish powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear blue-green solution at 10mg/ml Dichloromethane
Names and identifiers

Synonyms:

  • 3-Pyrrolin-2-one, 3-acetyl-5-sec-butyl-4-hydroxy-, L-

RTECS: UY7425000
 

 

Description

Tenuazonic acid is a natural mycotoxin, inhibitor of protein synthesis. Tenuazonic acid is offered as its Cuprum salt. 

 

InChl Key
LLXUERDQXVXQAY-UHFFFAOYSA-N
Canonical SMILES
CCC(C)C1C(=C(C(=O)N1)C(=O)C)O.CCC(C)C1C(=C(C(=O)N1)C(=O)C)O.[Cu]
Solubility ( literature )

Soluble in DMSO, pure ethanol, methanol

Compound Classification
  • Pyrrolidinone mycotoxin
  • Tenuazonic Acid Copper Salt is an antineoplastic agent and mycotoxin. It Inhibits protein synthesis, though which it has been shown inhibiting TPA-induced ornithine decarboxylase activity. Lack of ornithine decarboxylase has been shown to eventually cause DNA damage induced apoptosis. It has also been shown to inhibit photosystem II.
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Applications

This is a potential antineoplastic agent

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Semi-Synthetic
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Pg III
Fermentek Product Category
Mycotoxins
Alternaria toxins
Cytotoxic agents
Research field: Cancer
Apoptosis related
Anti Bacterial
Anti Viral
Anti Tumor agents
Signal to sort
T

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Tenuazonic_acid__Cu_salt_.gif
Tenuazonic_acid__Cu_salt_.gif

Staurosporine

Staurosporine
Molecular Formula
C28H26N4O3
M.W.
466.53
CAS number
62996-74-1
MSDS
Source
Streptomyces staurosporeus
Fermentek product Code
STA-001
Appearance
Off-white to light yellow powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
255°C-275°C
Solubility test
Clear colorless solution at 5mg/ml Ethyl Acetate,
Clear yellow solution at 25mg/ml DMSO
Names and identifiers

Synonyms:  Antibiotic AM 2282; 

RTECS: KD5084000   ;  attention: This RTECS record belongs to the Hydrochloride salt of Staurosporine, rather than the free base form.

EU number
613-127-7
Chemical name
Staurosporine
Description

Staurosporine is a cell permeable inhibitor of protein kinases, including protein kinase-C.   Inhibitor of nuclear factor kappa B kinase beta subunit.

InChl Key
HKSZLNNOFSGOKW-FYTWVXJKSA-N
Canonical SMILES
CC12C(C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)NC)OC
Isomeric SMILES
C[C@@]12[C@@H]([C@@H](C[C@@H](O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)NC)OC
Solubility ( literature )

DMSO, Methanol, Ethanol, Ethyl Acetate. Water insoluble

Compound Classification
  • Chemical classification: Indolocarbazole alkaloid
  • Bio-activity: PKC inhibitor
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Applications
  • Pharmacological tool to study signal transduction pathways, tyrosine phosphorylation and to induce apoptosis.
  • May participate in antigen-induced T-cell activation;
  • Affects Proto-oncogene serine/threonine-protein kinase Pim-1, T-cell-specific kinase, Tyrosine-protein kinase SYK, MAP kinase-activated protein kinase 2
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Shipped at ambient temperature
Shipped in PP / PE bottle.
Available since
Title
Transport information
Value
Not hazardous for transport
Title
Deleted CAS numbers
Value
109189-95-9
Title
Safety comments
Value
Others say it is cancerogen, explosive. We think, because theirs contains ligroyin.
Title
identity comments
Value
HCl salt thereof: C28-H26-N4-O3.Cl-H ; RTECS KD5084000;
Fermentek Product Category
Antibiotics
Enzyme-inhibitors
Research field: Cancer
Apoptosis related
Protein kinase related
Anti Fungal
Cancer Related Compounds
Anti Tumor agents
Research field: Signal Transduction
Signal to sort
S

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Staurosporine.gif
Staurosporine.gif

Stauprimide

Stauprimide
Molecular Formula
C35H28N4O4
M.W.
584.62
CAS number
154589-96-5
Source
Semisynthetic
Fermentek product Code
STP-001
Brand/grade
For research
Appearance
Yellow powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
230°C-237°C
Solubility test
Clear yellow solution at 10mg/ml of DMSO, Clear yellow solution at 5mg/ml of Methanol
Names and identifiers

chemical name:

N-Benzoyl-7-oxostaurosporine

 

Description

Promoter of stem cells differentiation;

InChl Key
MQCCJEYZKWZQHU-MPRCCEKMSA-N
Canonical SMILES
CC12C(C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)C(=O)NC6=O)N(C)C(=O)C9=CC=CC=C9)OC
Isomeric SMILES
C[C@@]12[C@@H]([C@@H](C[C@@H](O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)C(=O)NC6=O)N(C)C(=O)C9=CC=CC=C9)OC
Solubility ( literature )

Reportedly, Stauprimide is soluble in methanol, DMSO. Other sources mention ethanol (slightly), DMF, water (limited) and report 10% solutions in DMSO (100 mg/ml),

Compound Classification
  • Carbazole Antibiotic
  • Staurosporine derivative (from MeSH)
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend +2 to +8°C storage, room temperature, desication etc.
Retest time
3 Years
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Semi-Synthetic
Ingredient type
Fermentek product
Usually packed in amber-glass vials, 1 ml; capped with teflon lined plastic caps
Available since
Title
Transport information
Value
Not hazardous for transport
Fermentek Product Category
Research field: Cancer
Protein kinase related
Research field: Signal Transduction
Others
Signal to sort
S

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Price
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Stauprimide.gif
Stauprimide.gif

PX-866

PX-866 (Sonolisib)
Molecular Formula
C29H35NO8
M.W.
525.59
CAS number
502632-66-8
MSDS
Source
Semisynthetic
Fermentek product Code
PX8-001
Brand/grade
For research
Appearance
Orange powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
120°C-130°C
Solubility test
Clear yellowish solution at 10mg/ml of Methanol or DMSO
Names and identifiers

Synonym:

Sonolisib

Chemical name:

  • (1E,​4S,​4aR,​5R,​6aS,​9aR)-​5-​(acetyloxy)-​1-​[(di-​2-​propen-​1-​ylamino)methylene]-​4,​4a,​5,​6,​6a,​8,​9,​9a-​octahydro-​11-​hydroxy-​4-​(methoxymethyl)-​4a,​6a-​dimethyl-​cyclopenta[5,​6]naphtho[1,​2-​c]pyran-​2,​7,​10(1H)-​trione
  • Sonolisib
EU number
812-171-6
Description

PX-866 is a synthetic derivate of wortmannin.

InChl Key
QIUASFSNWYMDFS-NILGECQDSA-N
Canonical SMILES
CC(=O)OC1CC2(C(CCC2=O)C3=C1C4(C(OC(=O)C(=CN(CC=C)CC=C)C4=C(C3=O)O)COC)C)C
Isomeric SMILES
CC(=O)O[C@@H]1C[C@]2([C@@H](CCC2=O)C3=C1[C@]4([C@H](OC(=O)/C(=C/N(CC=C)CC=C)/C4=C(C3=O)O)COC)C)C
Solubility ( literature )

Methanol , DMSO, Ethyl acetate, Ethanol

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from moisture
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Applications
  • Potential anti-cancer agent;
  • Phosphatidylinositol 3-kinase inhibitor
Disclaimer
For Research use only
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Semi-Synthetic
Ingredient type
Fermentek product
Available since
Fermentek Product Category
Research field: Cancer
Cancer Related Compounds
Others
Signal to sort
P

Quote for

Price
$1.00
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PX-866__Sonolisib_.gif
Subscribe to Research field: Cancer