Cancer is most accurately described as a class of diseases characterized by uncontrolled cell growth and division.There are more than a hundred defined types of cancer.

Cancer can occur in nearly every organ or tissue in the body.

Various small molecules are widely used in the research of cancer. Especially in the last decade, cancer research has evolved from a one-size-fits-all approach that emphasized cytotoxic chemotherapy to a more personalized medical strategy that focuses on the discovery and development of targeted drugs.

These drugs are designed, on a molecular level, to exploit particular genetic dependencies, addictions, and vulnerabilities of cancer cells.

Much current cancer research is concentrated in the areas of programmed cell death, tumor invasion and angiogenesis, tumor immunology, oncogenic signaling, gene expression and copy number, epigenetic regulation, toxicity and chemoresistance, metabolic stress and damage to DNA. Fermentek offers more than 30 unique biochemicals currently being used in cancer research.

beta Zearalenol

beta Zearalenol
Molecular Formula
C18H24O5
M.W.
320.38
CAS number
71030-11-0
Source
Semisynthetic
Fermentek product Code
ZLB-001
Brand/grade
For research
Appearance
White powder
Purity by HPLC
≥97% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
160°C-175°C
Solubility test
Clear colorless solution at 10mg/ml of Methanol
Names and identifiers

Synonyms:

  • Beta-trans-Zearalenol
  • Beta-Zearalenol

Chemical names:

 

IUPAC:

(2E,7S,11S)-7,15,17-trihydroxy-11-methyl-12-oxabicyclo[12.4.0]octadeca-1(18),2,14,16-tetraen-13-one

 

RTECS#  DM2570000

EU number
664-283-8
Description

β-Zearalenol is a mycotoxin produced by several species of Fusarium. 
β-Zearalenol exhibits pronounced estrogenic activity, like other zearalenones. 
Contamination of grains by Fusarium species, notably maize, gives rise to high levels of zearalenol and is regarded as an important food quality issue for both human and animal health. 

InChl Key
FPQFYIAXQDXNOR-PMRAARRBSA-N
Canonical SMILES
CC1CCCC(CCCC=CC2=CC(=CC(=C2C(=O)O1)O)O)O
Isomeric SMILES
C[C@H]1CCC[C@H](CCC/C=C/C2=CC(=CC(=C2C(=O)O1)O)O)O
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from moisture
Protect from light !
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Semi-Synthetic
Ingredient type
Fermentek product
Available since
Title
Raw mat
Value
Not animal
Signal to sort
B

Veratridine

Veratridine
Molecular Formula
C36H51NO11
M.W.
673.79
CAS number
71-62-5
Source
Plant extract (Schoenocaulon officinale)
Fermentek product Code
VER-001
Brand/grade
For research
Appearance
White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
160°C-180°C
Solubility test
Clear colorless solution at 10mg/ml of DMSO or Methanol
Names and identifiers

Synonyms:   Veratrin (Amorphous)

Chemical names:  4,9-epoxycevane-3β,4α,12,14,16β,17,20-heptol 3-veratrate

IUPAC:   (3β,4α,16β)-4,12,14,16,17,20-Hexahydroxy-4,9-epoxycevan-3-yl 3,4-dimethoxybenzoate    

RTECS#  YX5600000

 

EU number
200-758-4
Description

Veratridine, plant-derived alkaloid is a potent modulator of voltage dependent Na+channels and hence, of transmitter release. Veratridine reduces the single channel conductance and increases the persistent opening propability.

InChl Key
FVECELJHCSPHKY-YFUMOZOISA-N
Canonical SMILES
CC1CCC2C(C3(C(CC4(C5CCC6C7(C5(CC4(C3CN2C1)O)OC6(C(CC7)OC(=O)C8=CC(=C(C=C8)OC)OC)O)C)O)O)O)(C)O
Isomeric SMILES
C[C@H]1CC[C@H]2[C@@]([C@]3([C@H](C[C@]4([C@@H]5CC[C@H]6[C@]7([C@]5(C[C@]4([C@@H]3CN2C1)O)O[C@@]6([C@H](CC7)OC(=O)C8=CC(=C(C=C8)OC)OC)O)C)O)O)O)(C)O
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Protect from moisture!
Retest time
3 Years
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
EU CN 29397990
Value
Alkaloids, natural or reproduced by synthesis, and their salts, ethers, esters and other derivatives; plant origin ; other;other
Title
CN FER 29419000
Value
Antibiotics other; other
Title
CN FER recommendation
Value
ONLY for research in the field of Cancer
Signal to sort
V

Chaetoglobosin A

Chaetoglobosin A
Molecular Formula
C32H36N2O5
M.W.
528.64
CAS number
50335-03-0
MSDS
Source
Chaetomium globosum
Fermentek product Code
CHA-001
Brand/grade
For research
Appearance
Yellow to slight yellow powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
165°C-170°C
Solubility test
Clear yellow solution at 10mg/ml of Methanol
Names and identifiers

Synonyms:

  • Chaetoglobosins;
  • Chaetoglobosin A;
  • CHAETOGLOBOSIN A;
  • CHAETOGLOBOSIN;
  • CHAETOGLOBOSINB;

Chemical names:

IUPAC:

(1E,4S,5E,7R,9E,11aR,14S,14aR,15S,15aR,16aS,16bR)-7-Hydroxy-14-(1H-indol-3-ylmethyl)-4,6,15,15a-tetramethyl-4,7,14,14a,15,15a,16a,16b-octahydro-3H-cyclotrideca[d]oxireno[f]isoindole-8,11,12(13H)-trion e

 

RTECS#:

  • HA530500
EU number
not assigned
Chemical name
Chaetoglobosin A
Description

Antibiotic agent.

Phytotoxin. Cytochalasin analog

  • Targets filamentous actin and induces apoptosis.
  • Shows cytotoxic effects against cancer cell lines.
  • Shows antibacterial and nematicidal effects.
  • Induces tissue necrosis in vivo
InChl Key
OUMWCYMRLMEZJH-VOXRAUTJSA-N
Canonical SMILES
CC1CC=CC2C3C(O3)(C(C4C2(C(=O)C=CC(=O)C(C(=C1)C)O)C(=O)NC4CC5=CNC6=CC=CC=C65)C)C
Isomeric SMILES
C[C@H]1[C@H]2[C@@H](NC(=O)[C@@]23[C@@H](/C=C/CC(/C=C(/[C@H](C(=O)/C=C/C3=O)O)\C)C)[C@H]4[C@@]1(O4)C)CC5=CNC6=CC=CC=C65
Solubility ( literature )

Soluble in DMSO , Ethanol, Methanol

Compound Classification

Chemical classification:

  • Indole Alkaloids

Bioactivity classiification:

  • antibacterial
  • cytotoxic
  • Apoptosos inducer
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from moisture
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Not hazardous for transport
Title
toxicity by RTECS
Value
Rodent - rat; Oral LD50 - = >400 mg/kg
Signal to sort
C

Enniatin B

Enniatin B
Molecular Formula
C33H57N3O9
M.W.
639.82
CAS number
917-13-5
Source
Fusarium sp.
Fermentek product Code
ENB-001
Brand/grade
For research
Appearance
White to Off-White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
172°C-176°C
Solubility test
Clear colorless solution at 10mg/ml of Dichloromethane or Methanol
Names and identifiers

 

Synonyms:

Chemical names:

IUPAC:

(3S,6R,9S,12R,15S,18R)-4,10,16-trimethyl-3,6,9,12,15,18-hexa(propan-2-yl)-1,7,13-trioxa-4,10,16-triazacyclooctadecane-2,5,8,11,14,17-hexone

IUPAC Condensed name, as an oligopeptide
cyclo[N(Me)Val-D-OVal-N(Me)Val-D-OVal-N(Me)Val-D-OVal]

RTECS n.a.

Description

Enniatin B is the most studied of four major analogues of the enniatin complex.

InChl Key
MIZMDSVSLSIMSC-VYLWARHZSA-N
Canonical SMILES
CC(C)C1C(=O)OC(C(=O)N(C(C(=O)OC(C(=O)N(C(C(=O)OC(C(=O)N1C)C(C)C)C(C)C)C)C(C)C)C(C)C)C)C(C)C
Isomeric SMILES
CC(C)[C@H]1C(=O)O[C@@H](C(=O)N([C@H](C(=O)O[C@@H](C(=O)N([C@H](C(=O)O[C@@H](C(=O)N1C)C(C)C)C(C)C)C)C(C)C)C(C)C)C)C(C)C
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since

Enniatin (complex)

Enniatin (complex)
Molecular Formula
C33H57N3O9
M.W.
639.80
CAS number
11113-62-5
Source
Fusarium sp
Fermentek product Code
ENC-001
Brand/grade
For research
Appearance
White to Off-White powder
Purity by HPLC
≥98% as complex ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless solution at 10mg/ml Dichloromethane
or Methanol
Names and identifiers

Synonyms:
Enniatins

Chemical names:
Enniatin complex;

IUPAC:
4,10,16-trimethyl-3,6,9,12,15,18-hexa(propan-2-yl)-1,7,13-trioxa-4,10,16-triazacyclooctadecane-2,5,8,11,14,17-hexone

RTECS : n.a.
 

 

Description

Enniatins are a family of depsipeptides produced by several species of Fusaria. Enniatins have initially been shown to act as ionophores. Later, their effects on acyl-CoA cholesterol transferase, ABC-transporters and the selectivity of their antitumor action are emphasized in the research.

InChl Key
MIZMDSVSLSIMSC-OGLSAIDSSA-N
Canonical SMILES
CC(C)[C@H]1C(=O)OC(C(=O)N([C@H](C(=O)OC(C(=O)N([C@H](C(=O)OC(C(=O)N1C)C(C)C)C(C)C)C)C(C)C)C(C)C)C)C(C)C
Compound Classification

Depsipeptide antibiotic.

Ammonium Ionophore.

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from moisture
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Applications

Mentioned as a replacement for Nonactin, in manufacturing on ammonium specific electrodes.

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Not hazardous for transport
Signal to sort
E

Turmerone, (S)-ar-

(S)-ar-Turmerone
Molecular Formula
C15H20O
M.W.
216.30
CAS number
532-65-0
Source
Curcuma longa (extracted from plant)
Fermentek product Code
ART-001
Brand/grade
For research
Appearance
Yellowish oil
Purity by HPLC
≥97% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless solution 10mg in 1ml of Ethanol or Petroleum ether
Names and identifiers

Synonyms:
(S)-ar-Turmerone

IUPAC Name:
(6S)-2-Methyl-6-(4-methylphenyl)-2-hepten-4-one

Disambiguation:  
CAS [532-65-0] means S-ar-Turmerone, while CAS [82508-15-4] belongs to a closely related compound TURMERON, which has two hydrogenes more.

Disambiguation: 
Turmerin, an oligo-peptide,  from Curcuma longa roots, not to be mistaken for Turmerone, a small molecule of the same source

REACH No. :
A registration number is not available for this substance as the substance or its uses are exempted from registration, the annual tonnage does not require a registration or the registration is envisaged for a later registration deadline.

EU number
664-010-2
Chemical name
2-Hepten-4-one, 2-methyl-6-(4-methylphenyl)-, (S)-
Description

Natural antibiotic of herbal origin, known as potent anti-venom against snake bites; Reported to enhance stem-cells proliferation; Reported as a factor in the regeneration of neural cells and brain damage. Reported to have anti-inflammatory properties.

(S)-ar-Turmerone is an anti-tumor and immune activating agent, which maintains a cytotoxic effect in cancer cells. Also, an antimicrobial agent.

InChl Key
NAAJVHHFAXWBOK-ZDUSSCGKSA-N
Canonical SMILES
CC1=CC=C(C=C1)C(C)CC(=O)C=C(C)C
Isomeric SMILES
CC1=CC=C(C=C1)[C@@H](C)CC(=O)C=C(C)C
Solubility ( literature )

Hexane, Petrol ether, Ethanol, Methanol

Compound Classification

Sesquiterpene type natural antibiotic.

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Applications

Known as potent anti-venom against snake bites; Reported to enhance stem-cells proliferation; Reported as a factor in the regeneration of neural cells and brain damage. Reported to have anti-inflammatory properties.

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Pg III; Environmentally hazardous;
Fermentek Product Category
Signal to sort
T

Chaetocin

Chaetocin
Molecular Formula
C30H28N6O6S4
M.W.
696.84
CAS number
28097-03-2
Source
From Chaetomium sp
Fermentek product Code
CHT-001
Brand/grade
For research
Appearance
White powder
Purity by HPLC
≥95% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless solution at 25 mg/ml DMSO
Names and identifiers

Synonyms

  • Chetocin
  • Chaetocin
  • (3S,3'S,5aR,5aR,10bR,10'bR,11aS,11'aS)-2,2',3,3',5a,5'a,6,6'-octahydro-3,3'-bis(hydroxymethyl)-2,2'-dimethyl-[10b,10'b(11H,11'H)-bi3,11a-epidithio-11aH-pyrazino[1',2':1,5]pyrrolo[2,3-b]indole]-1,1',4,4'-tetrone

RTECS: FM3032000

EU number
636-696-3
Description

A fungal metabolite which inhibits G9a histone methyltransferase.

InChl Key
PZPPOCZWRGNKIR-PNVYSBBASA-N
Canonical SMILES
CN1C(=O)C23CC4(C(N2C(=O)C1(SS3)CO)NC5=CC=CC=C54)C67CC89C(=O)N(C(C(=O)N8C6NC1=CC=CC=C71)(SS9)CO)C
Isomeric SMILES
c12c(N[C@@H]3N4[C@@]5(C[C@@]23[C@@]23c6c(N[C@@H]2N2[C@@]7(C3)C(N([C@@](C2=O)(SS7)CO)C)=O)cccc6)C(N([C@@](CO)(C4=O)SS5)C)=O)cccc1
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Retest time
3 Years
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
Deleted CAS Numbers:
Value
31794-18-0
Title
Inhibitor of:
Value
G9a histone methyltransferase
Title
Transport information
Value
Not hazardous for transport
Title
Research Areas
Value
HIV
Signal to sort
C

Epigallocatechin Gallate

Epigallocatechin Gallate
Molecular Formula
C22H18O11
M.W.
458.40
CAS number
989-51-5
Source
Extracted from Green Tea (leaves)
Fermentek product Code
EPG-001
Brand/grade
For research
Appearance
White to Beige lyophilized powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless solution at 10 mg/ml H2O
Names and identifiers

RTECS KB5200000

EU number
619-381-5
Chemical name
[(2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl] 3,4,5-trihydroxybenzoate
Description

Epigallocatechin is a phenolic antioxidant found in a number of plants such as green and black tea.
Epigallocatechin inhibits cellular oxidation and prevents free radical damage to cells. 

 

InChl Key
WMBWREPUVVBILR-WIYYLYMNSA-N
Canonical SMILES
C1C(C(OC2=CC(=CC(=C21)O)O)C3=CC(=C(C(=C3)O)O)O)OC(=O)C4=CC(=C(C(=C4)O)O)O
Isomeric SMILES
C1[C@H]([C@H](OC2=CC(=CC(=C21)O)O)C3=CC(=C(C(=C3)O)O)O)OC(=O)C4=CC(=C(C(=C4)O)O)O
Compound Classification

- Antioxidant

- Potential cancer-preventive agent. 

- Inhibitor of Telomerase

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from light !
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Applications

Epigallocatechin is being studied as a potential cancer chemo preventive agent.

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since

KT5555 (Lestaurtinib)

KT5555 (Lestaurtinib)
Molecular Formula
C26H21N3O4
M.W.
439.50
CAS number
111358-88-4
Source
Semisynthetic
Fermentek product Code
LES-001
Brand/grade
For research
Appearance
White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
233°C-243°C
Solubility test
Clear colorless solution at 20mg/ml DMSO
Names and identifiers

IUPAC/Chemical name:  (5S,6S,8R)-6-hydroxy-6-(hydroxymethyl)-5-methyl-7,8,14,15-tetrahydro-5H-16-oxa-4b,8a,14-triaza-5,8-methanodibenzo[b,h]cycloocta[jkl]cyclopenta[e]-as-indacen-13(6H)-one

Synonyms

  • KT5555
  • Lestaurtinib

 

 

Description

KT5555 is a multi targeted tyrosine kinase inhibitor.

InChl Key
UIARLYUEJFELEN-LROUJFHJSA-N
Canonical SMILES
CC12C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)(CO)O
Isomeric SMILES
C[C@@]12[C@](C[C@@H](O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)(CO)O
Compound Classification

Chemical classification

  • Indole alcaloids - Carbazoles - Staurosporine-derivates

Bioactivity classification

  • Enzyme inhibitors
  • Proteine kinase inhibitors / Tyrosine kinase inhibitors
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from light !
Use the original container to store the product.
Keep the lid tightly closed.
Store under argon.
Retest time
3 Years
Applications

It is used for the treatment of pancreatic cancer and acute myelogenous leukaemia (AML).

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Semi-Synthetic
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Not hazardous for transport
Title
CN code
Value
29349990
Title
CN code
Value
NO!!!
Title
inert gas storage
Value
after merck, TRC, carbosynth
Signal to sort
K

Roquefortine C

Roquefortine C
Molecular Formula
C22H23N5O2
M.W.
389.50
CAS number
58735-64-1
Source
Penicillium roqueforti
Fermentek product Code
RQC-001
Brand/grade
For research
Appearance
White to slightly yellow powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless solution at 10 mg/ml Methanol or DMSO
Names and identifiers

Synonyms

  • Roquefortine
  • Roquefortin
  • roquefortine C
  • Rorifone

RTECS: UQ4730500

HSDB 7246

Description

Roquefortine C is a mycotoxin produced by various fungi, particularly species from the Penicillium genus. It was first isolated from a strain of Penicillium roqueforti, a species commercially used to make Roquefort, Danish Blue, Stilton and Gorgonzola cheeses.

InChl Key
SPWSUFUPTSJWNG-CXUHLZMHSA-N
Canonical SMILES
CC(C)(C=C)C12CC3C(=O)NC(=CC4=CN=CN4)C(=O)N3C1NC5=CC=CC=C25
Isomeric SMILES
CC(C)(C=C)C12CC3C(=O)N/C(=C/C4=CN=CN4)/C(=O)N3C1NC5=CC=CC=C25
Solubility ( literature )

Soluble in 100% ethanol, methanol (10 mg/ml), DMSO (10 mg/ml), DMF, and water (poor).

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from moisture
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Warnings
Ingredient type
Fermentek product
Available since
Title
Transport Information
Value
Not Dangerous Goods
Title
toxicity by RTECS
Value
Rodent - mouse ; intraoeritoneal LD50 = 15 mg/kg; no other data
Signal to sort
R