Swainsonine

Swainsonine
Molecular Formula
C8H15NO3
M.W.
173.20
CAS number
72741-87-8
Source
Metharhizium anisopliae
Fermentek product Code
SWA-001
Brand/grade
For research
Appearance
White to beige to slight yellow lyophilizied powder
Purity By TLC
No impurities visible, by multiple methods.
Solubility test
Clear colorless to light yellow solution at 10mg/ml of Water.
Clear colorless to light yellow solution at 5 mg/ml of Methanol
Names and identifiers

Synonyms:

Swainsonine;           

8A,B-INDOLIZIDINE-1,2A,8B-TRIOL;                  

SWAINSONINE;           

Tridolgosir;

 (1S,2R,8R,8aR)-octahydro-1,2,8-indolizinetriol; 

Chemical names:

IUPAC: (1S,2R,8R,8aR)-1,2,3,5,6,7,8,8a-octahydroindolizine-1,2,8-triol

RTECS# NM2408666

EU number
615-797-6
Description

An indolizidine alkaloid from fungus Metharhizium anisopliae,  a potent alpha-mannosidase inhibitor.

Swainsonine also exhibits antimetastatic, antiproliferative, and immunomodulatory activity.

InChl Key
FXUAIOOAOAVCGD-WCTZXXKLSA-N
Canonical SMILES
C1CC(C2C(C(CN2C1)O)O)O
Isomeric SMILES
C1C[C@H]([C@@H]2[C@@H]([C@@H](CN2C1)O)O)O
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Protect from moisture!
Retest time
3 Years
Applications

Swainsonine has a potential for treating cancers such as glioma and gastric carcinoma.
However, a phase II clinical trial of GD0039 (a hydrochloride salt of swainsonine) in 17 patients with renal carcinoma was discouraging.

Swainsonine's activity against tumors is attributed to its stimulation of macrophages.
Swainsonine also has potential uses as an adjuvant for anti-cancer drugs and other therapies in use.
In mice, swainsonine reduces the toxicity of doxorubicin, suggesting that swainsonine might enable use of higher doses of doxorubicin.
Swainsonine may promote restoration of bone marrow damaged by some types of cancer treatments.

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Not hazardous for transport
Fermentek Product Category
Enzyme-inhibitors
Research field: Cancer
Angiogenesis related
Immunomodulators
Others
Signal to sort
S

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Swainsonine.gif
Swainsonine.gif

KT5555 (Lestaurtinib)

KT5555 (Lestaurtinib)
Molecular Formula
C26H21N3O4
M.W.
439.50
CAS number
111358-88-4
Source
Semisynthetic
Fermentek product Code
LES-001
Brand/grade
For research
Appearance
White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
233°C-243°C
Solubility test
Clear colorless solution at 20mg/ml DMSO
Names and identifiers

IUPAC/Chemical name:  (5S,6S,8R)-6-hydroxy-6-(hydroxymethyl)-5-methyl-7,8,14,15-tetrahydro-5H-16-oxa-4b,8a,14-triaza-5,8-methanodibenzo[b,h]cycloocta[jkl]cyclopenta[e]-as-indacen-13(6H)-one

Synonyms

  • KT5555
  • Lestaurtinib

 

 

Description

KT5555 is a multi targeted tyrosine kinase inhibitor.

InChl Key
UIARLYUEJFELEN-LROUJFHJSA-N
Canonical SMILES
CC12C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)(CO)O
Isomeric SMILES
C[C@@]12[C@](C[C@@H](O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)(CO)O
Compound Classification

Chemical classification

  • Indole alcaloids - Carbazoles - Staurosporine-derivates

Bioactivity classification

  • Enzyme inhibitors
  • Proteine kinase inhibitors / Tyrosine kinase inhibitors
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from light !
Use the original container to store the product.
Keep the lid tightly closed.
Store under argon.
Retest time
3 Years
Applications

It is used for the treatment of pancreatic cancer and acute myelogenous leukaemia (AML).

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Semi-Synthetic
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Not hazardous for transport
Title
CN code
Value
29349990
Title
CN code
Value
NO!!!
Title
inert gas storage
Value
after merck, TRC, carbosynth
Fermentek Product Category
Antibiotics
Research field: Cancer
Protein kinase related
Research field: Signal Transduction
Others
Signal to sort
K

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Lestaurtinib__KT5555_.gif
Lestaurtinib__KT5555_.gif

Dimethylamino Parthenolide (DMAPT)

Dimethylamino Parthenolide (DMAPT)
Molecular Formula
C17H27NO3
M.W.
293.40
CAS number
795195-09-7
Source
Synthetic
Fermentek product Code
DMP-001
Brand/grade
For research
Appearance
White crystalline solid.
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
145°C-153°C
Solubility test
Clear colorless solution at 10 mg/ml Ethanol or DMSO or Dichloromethane.
Description

DMAPT is water soluble semi-synthetic derivate of Parthenolide.

InChl Key
UJNSFDHVIBGEJZ-ONGJMVGKSA-N
Canonical SMILES
CC1=CCCC2(C(O2)C3C(CC1)C(C(=O)O3)CN(C)C)C
Isomeric SMILES
C/C/1=C\CC[C@@]2([C@@H](O2)[C@@H]3[C@@H](CC1)[C@@H](C(=O)O3)CN(C)C)C
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Use the original container to store the product.
Keep the lid tightly closed.
Avoid moisture.
Retest time
3 Years
Applications

DMAPT has been reported as antiviral, anti HIV, anti Hepatitis C virus

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Semi-Synthetic
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Not hazardous for transport
Fermentek Product Category
Research field: Cancer
Apoptosis related
Cancer Related Compounds
Research field: Inflamation
Others
Signal to sort
D

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DMAPT_0.png
Dimethylamino_Parthenolide.gif
DMAPT_0.png
Dimethylamino_Parthenolide.gif

Wortmannin

Wortmannin
Molecular Formula
C23H24O8
M.W.
428.44
CAS number
19545-26-7
Source
Talaromyces (Penicillium) wortmannii
Fermentek product Code
WOR-001
Brand/grade
For research
Appearance
White to slight yellow powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
230°C-240°C
Solubility test
Clear colorless to faint yellow solution at 5 mg/ml Methanol;
Clear colorless to faint yellow solution at 10mg/ml Ethyl Acetate;
Names and identifiers

Synonyms:

  • Wartmannin
  • Antibiotic SL-2052

Systematic Name:

  • (1alpha,11alpha)-11-(Acetyloxy)-1-(methoxymethyl)-2-oxaandrosta-5,8-dieno(6,5,4-bc)furan-3,7,17-trione

RTECS: CB641000

EU number
606-337-5
Chemical name
Wortmannin
Description

Wortmannin is a steroid metabolite of the fungus Talaromyces wortmannii. It is a specific covalent inhibitor of phosphoinositide 3-kinases. Wortmannin has been used as precursor of an experimental anti-cancer drug PX-866

InChl Key
QDLHCMPXEPAAMD-QAIWCSMKSA-N
Canonical SMILES
CC(=O)OC1CC2(C(CCC2=O)C3=C1C4(C(OC(=O)C5=COC(=C54)C3=O)COC)C)C
Isomeric SMILES
CC(=O)O[C@@H]1C[C@]2([C@@H](CCC2=O)C3=C1[C@]4([C@H](OC(=O)C5=COC(=C54)C3=O)COC)C)C
Solubility ( literature )

DMSO, Methanol.

Wortmannin is unstable in aqueous and ethanolic solutions.

Compound Classification
  • chemical class: Androstadiene.
  • phospholipase D inhibitor.
  • phosphatidylinositol 3-kinase inhibitor.
  • Immunosupressor.
  • Antifungal.
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Protect from moisture! Hygroscopic substance.
Retest time
3 Years
Applications

Wortmannin is an inhibitor of phosphatidyl-inositol 3-kinase Wortmannin inhibits the growth of mammary tumors despite the existence of a novel wortmannin-insensitive phosphatidylinositol-3-kinase. Wortmannin inhibits repair of DNA double-strand breaks in irradiated normal human cells. Wortmannin was shown to have enhancing influence on memory and impair learning abilities. .

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
Deleted CAS number:
Value
1405-03-4
Title
Transport information
Value
PG I
Fermentek Product Category
Enzyme-inhibitors
Research field: Cancer
Protein kinase related
Anti Fungal
Others
Signal to sort
W

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Wortmannin.gif
Wortmannin.gif

Triacsin C

Triacsin C
Molecular Formula
C11H17N3O
M.W.
207.27
CAS number
76896-80-5
MSDS
Source
Streptomyces aureofaciens
Fermentek product Code
TRC-001
Brand/grade
For research
Appearance
Off-white to Dark yellow powder
Purity by HPLC
≥90% ; refer to CoA for more data
Purity By TLC
≥95% ; refer to CoA for more data
Solubility test
Clear yellowish to yellow solution at 5mg/ml of Methanol or DMSO
Names and identifiers

Synonyms

  • 2E, 4E, 7E-Undecatriene-1-triazene
  • 1-hydroxy-3-(2',4',7'-undecatrienylidine)triazene

 

EU number
616-408-2
Chemical name
2,4,7-Undecatrienal, nitrosohydrazone, (2E,4E,7E)-
Description

Triacsin C, an analog of polyunsaturated fatty acid. A potent vasodilator.

InChl Key
NKTGCVUIESDXPU-YLEPRARLSA-N
Canonical SMILES
CCCC=CCC=CC=CC=NNN=O
Isomeric SMILES
CCC/C=C/C/C=C/C=C/C=N/NN=O
Solubility ( literature )

Soluble to 25 mM in DMSO (lit)

Compound Classification

Chemical classification:

  • Triazene class compound
  • Polyunsaturated fatty acid analog.

Classification by bioactivities:

  • Arachidonoyl-CoA synthetase inhibitor
  • Inhibits Synthesis of triacylglycerol and phospholipid
  • Apoptosis inhibitor
  • Vasodilator
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from moisture
Protect from light !
Avoid exposing to strong direct light.
Store under argon.
Other vendors may recommend higher temperatures for storage.
Attention: this compound may deteriorate quickly if stored improperly
Retest time
1.5 Years
Applications

Selectively inhibits arachidonoyl-CoA synthetase in intact cells. Inhibits the nonspecific acyl-CoA synthetase in cell sonicates. Inhibits neutrophil functions. Inhibits lipid synthesis and cell proliferation in Raji lymphoma cells. Induces apoptosis in cancer cell lines and inhibits human lung cancer cell xenograft tumor growth in mice.

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
Inhibitor of:
Value
Selective inhibitor of acyl-CoA synthetase
Title
Transport information
Value
Not hazardous for transport
Title
Specifications updated 24-October 2017
Value
Purity ≥90% by HPLC
Fermentek Product Category
Enzyme-inhibitors
Cardiovascular agents
Vasodilator Agents
Others
Signal to sort
T

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Price
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Triacsin_C.gif
Triacsin_C.gif

Stauprimide

Stauprimide
Molecular Formula
C35H28N4O4
M.W.
584.62
CAS number
154589-96-5
Source
Semisynthetic
Fermentek product Code
STP-001
Brand/grade
For research
Appearance
Yellow powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
230°C-237°C
Solubility test
Clear yellow solution at 10mg/ml of DMSO, Clear yellow solution at 5mg/ml of Methanol
Names and identifiers

chemical name:

N-Benzoyl-7-oxostaurosporine

 

Description

Promoter of stem cells differentiation;

InChl Key
MQCCJEYZKWZQHU-MPRCCEKMSA-N
Canonical SMILES
CC12C(C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)C(=O)NC6=O)N(C)C(=O)C9=CC=CC=C9)OC
Isomeric SMILES
C[C@@]12[C@@H]([C@@H](C[C@@H](O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)C(=O)NC6=O)N(C)C(=O)C9=CC=CC=C9)OC
Solubility ( literature )

Reportedly, Stauprimide is soluble in methanol, DMSO. Other sources mention ethanol (slightly), DMF, water (limited) and report 10% solutions in DMSO (100 mg/ml),

Compound Classification
  • Carbazole Antibiotic
  • Staurosporine derivative (from MeSH)
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend +2 to +8°C storage, room temperature, desication etc.
Retest time
3 Years
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Semi-Synthetic
Ingredient type
Fermentek product
Usually packed in amber-glass vials, 1 ml; capped with teflon lined plastic caps
Available since
Title
Transport information
Value
Not hazardous for transport
Fermentek Product Category
Research field: Cancer
Protein kinase related
Research field: Signal Transduction
Others
Signal to sort
S

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Price
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Stauprimide.gif
Stauprimide.gif

PX-866

PX-866 (Sonolisib)
Molecular Formula
C29H35NO8
M.W.
525.59
CAS number
502632-66-8
MSDS
Source
Semisynthetic
Fermentek product Code
PX8-001
Brand/grade
For research
Appearance
Orange powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
120°C-130°C
Solubility test
Clear yellowish solution at 10mg/ml of Methanol or DMSO
Names and identifiers

Synonym:

Sonolisib

Chemical name:

  • (1E,​4S,​4aR,​5R,​6aS,​9aR)-​5-​(acetyloxy)-​1-​[(di-​2-​propen-​1-​ylamino)methylene]-​4,​4a,​5,​6,​6a,​8,​9,​9a-​octahydro-​11-​hydroxy-​4-​(methoxymethyl)-​4a,​6a-​dimethyl-​cyclopenta[5,​6]naphtho[1,​2-​c]pyran-​2,​7,​10(1H)-​trione
  • Sonolisib
EU number
812-171-6
Description

PX-866 is a synthetic derivate of wortmannin.

InChl Key
QIUASFSNWYMDFS-NILGECQDSA-N
Canonical SMILES
CC(=O)OC1CC2(C(CCC2=O)C3=C1C4(C(OC(=O)C(=CN(CC=C)CC=C)C4=C(C3=O)O)COC)C)C
Isomeric SMILES
CC(=O)O[C@@H]1C[C@]2([C@@H](CCC2=O)C3=C1[C@]4([C@H](OC(=O)/C(=C/N(CC=C)CC=C)/C4=C(C3=O)O)COC)C)C
Solubility ( literature )

Methanol , DMSO, Ethyl acetate, Ethanol

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from moisture
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Applications
  • Potential anti-cancer agent;
  • Phosphatidylinositol 3-kinase inhibitor
Disclaimer
For Research use only
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Semi-Synthetic
Ingredient type
Fermentek product
Available since
Fermentek Product Category
Research field: Cancer
Cancer Related Compounds
Others
Signal to sort
P

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Price
$1.00
PX-866__Sonolisib_.gif
PX-866__Sonolisib_.gif

PKC412

PKC412 (Midostaurin)
Molecular Formula
C35H30N4O4
M.W.
570.60
CAS number
120685-11-2
Source
Synthetic
Fermentek product Code
PKC-001
Brand/grade
For research
Appearance
White to off-white powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
225°C-235°C
Solubility test
Clear colorless solution at 10mg/ml DMSO; Clear colorless solution at 5mg/ml methanol
Names and identifiers

Synonyms:

  • Midostaurin
  • PKC412
  • Benzoylstaurosporine
  • 4'-N-Benzoylstaurosporine

Commercial names: 

  • Rydapt

RTECS: CV5045180

Chemical name
4'-N-benzoyl staurosporine
Description

PKC412 (Midostaurin) is a cell permeable inhibitor of protein kinases, including protein kinase-C.

InChl Key
BMGQWWVMWDBQGC-UHFFFAOYSA-N
Canonical SMILES
CC12C(C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)N(C)C(=O)C9=CC=CC=C9)OC
Solubility ( literature )

Soluble in DMSO, Dichloromethane.
Water solubility : < 0.1 mg/1

Compound Classification
  • indolocarbazole alkaloid
  • PKC inhibitor
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Protect from moisture! Hygroscopic substance.
Retest time
3 Years
Applications
  • PKC412 is mentioned as a specific treatment for Myeloproliferative Disease (MPD)
  • PKC412 selectively inhibits protein kinase C (PKC)
  • Investigated for use/treatment in adult patients with high-risk acute myeloid leukemia (AML)
Disclaimer
Semi-Synthetic.
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Not hazardous for transport
Fermentek Product Category
Research field: Cancer
Angiogenesis related
Protein kinase related
Cancer Related Compounds
Research field: Signal Transduction
Others
Signal to sort
P

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Price
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PKC412__Midostaurin_.gif
PKC412__Midostaurin_.gif

Oligomycin B

Oligomycin B
Molecular Formula
C45H72O12
M.W.
805.05
CAS number
11050-94-5
Source
Streptomyces diastatochromogenes
Fermentek product Code
OLB-001
Brand/grade
For research
Appearance
White powder
Purity by HPLC
≥95% ; refer to CoA for more data
Melting point
160°C-175°C
Solubility test
Clear colorless solution at 5 mg/ml Methanol
Names and identifiers

Oligomycin B

Oligomycin A, 28-oxo-

EU number
234-275-5
Description

Oligomycin B: a macrolide antibiotic that inhibits membrane bound mitochondrial ATPase.

Oligomycin B product from Fermentek is practically free of homologs.

InChl Key
QPRQJOHKNJIMGN-UXAQBZNTSA-N
Canonical SMILES
CCC1CCC2C(C(C(C3(O2)C(=O)CC(C(O3)CC(C)O)C)C)OC(=O)C=CC(C(C(C(=O)C(C(C(C(=O)C(C(C(CC=CC=C1)C)O)(C)O)C)O)C)C)O)C)C
Isomeric SMILES
CC[C@H]/1CC[C@@H]2[C@@H]([C@@H]([C@H]([C@@]3(O2)C(=O)C[C@H]([C@H](O3)C[C@H](C)O)C)C)OC(=O)/C=C/[C@H]([C@@H]([C@H](C(=O)[C@H]([C@@H]([C@H](C(=O)[C@@]([C@@H]([C@H](C/C=C/C=C1)C)O)(C)O)C)O)C)C)O)C)C
Solubility ( literature )

Dichloromethane, DMSO, Ethanol, Acetone

Compound Classification

macrolideATPase inhibitor

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Applications

Used as a tool in cytochemistry

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Ingredient type
Fermentek product
Title
Transport information
Value
Not hazardous for transport
Fermentek Product Category
Research field: Signal Transduction
Others
Signal to sort
O

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Price
$1.00
Oligomycin_B.gif
Oligomycin_B.gif

Oligomycin A

Oligomycin A
Molecular Formula
C45H74O11
M.W.
791.06
CAS number
579-13-5
MSDS
Source
Streptomyces diastatochromogenes
Fermentek product Code
OLA-001
Brand/grade
For research
Appearance
White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
148°C-152°C
Solubility test
Clear colorless solution at 10 mg/ml Methanol or Dichloromethane
Names and identifiers

 

EINECS 209-437-3

RTECS: RK3328000

EU number
209-437-3
Description

Oligomycin A: a macrolide antibiotic that inhibits membrane bound mitochondrial ATPase. Practically free of homologs

InChl Key
MNULEGDCPYONBU-WMBHJXFZSA-N
Canonical SMILES
CCC1CCC2C(C(C(C3(O2)CCC(C(O3)CC(C)O)C)C)OC(=O)C=CC(C(C(C(=O)C(C(C(C(=O)C(C(C(CC=CC=C1)C)O)(C)O)C)O)C)C)O)C)C
Isomeric SMILES
CC[C@H]\1CC[C@@H]2[C@@H]([C@@H]([C@H]([C@@]3(O2)CC[C@H]([C@H](O3)C[C@H](C)O)C)C)OC(=O)/C=C/[C@H]([C@@H]([C@H](C(=O)[C@H]([C@@H]([C@H](C(=O)[C@@]([C@@H]([C@H](C/C=C/C=C1)C)O)(C)O)C)O)C)C)O)C)C
Solubility ( literature )

Dichloromethane, DMSO, Ethanol, Acetone

Compound Classification

macrolideATPase inhibitor

Retest time
3 Years
Applications

Used as a tool in cytochemistry

Disclaimer
Semi-Synthetic
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Not hazardous for transport
Fermentek Product Category
Research field: Signal Transduction
Others
Signal to sort
O

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Price
$1.00
Oligomycin_A.gif
Oligomycin_A.gif
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