Oligomycin (complex)

Oligomycin (complex)
Molecular Formula
C45H74O11
M.W.
791.06
CAS number
1404-19-9
MSDS
Source
Streptomyces diastatochromogenes
Fermentek product Code
OLG-001
Brand/grade
For research
Appearance
White powder
Purity by HPLC
≥90% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless solution at 10mg/ml Ethanol or Methanol
EU number
215-767-9
Description

 

  • Oligomycin (complex): a macrolide antibiotic that inhibits membrane bound mitochondrial ATPase. 
  • Oligomycin (complex) is a mixture of A, B, C isomers and other analogs.
  • The molecular weight and molecular structure shown on this page, are of Oligomycin A, the major component.
  • HPLC shows separately the concentrations of all components. Their ratio is not consistent and may vary from lot to lot. The analysis of the components is brought in CoA of particular lots.
  • The three components are also offered as separate products.
InChl Key
MNULEGDCPYONBU-DJRUDOHVSA-N
Canonical SMILES
CCC1CCC2C(C(C(C3(O2)CCC(C(O3)CC(C)O)C)C)OC(=O)C=CC(C(C(C(=O)C(C(C(C(=O)C(C(C(CC=CC=C1)C)O)(C)O)C)O)C)C)O)C)C
Isomeric SMILES
CC[C@@H]/1CC[C@H]2C(C([C@H]([C@@]3(O2)CC[C@H]([C@H](O3)CC(C)O)C)C)OC(=O)/C=C/[C@@H]([C@H]([C@H](C(=O)C([C@@H]([C@H](C(=O)[C@@]([C@@H]([C@H](C/C=C/C=C1)C)O)(C)O)C)O)C)C)O)C)C
Solubility ( literature )

Dichloromethane, DMSO, Ethanol, Acetone

Compound Classification

Chemical class: Macrolide

Bioactivity class: Mitochondrial ATP Synthase Inhibitor

 
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from moisture
Use the original container to store the product.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Applications

Used as a tool in cytochemistry.

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Not hazardous for transport
Title
Safety comments
Value
H302 Harmful if swallowed
Title
Deleted CAS Registry Numbers
Value
11098-49-0
Fermentek Product Category
Apoptosis related
Anti Bacterial
Others
Signal to sort
O

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$1.00
Oligomycin__complex_.gif
Oligomycin__complex_.gif

Okadaic Acid

Okadaic Acid
Molecular Formula
C44H68O13
M.W.
805.00
CAS number
78111-17-8
Source
Marine dinoflagellates
Fermentek product Code
OKA-001
Brand/grade
For research
Appearance
White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless solution at 5mg/ml EtOH;
Clear colorless solution at 40mg/ml DMSO
Names and identifiers

RTECS AA8227800

EU number
616-589-8
Chemical name
Acanthifolicin, 9,10-deepithio-9,10-didehydro-
Description

Inhibitor of protein phosphatase

InChl Key
QNDVLZJODHBUFM-WFXQOWMNSA-N
Canonical SMILES
CC1CCC2(CCCCO2)OC1C(C)CC(C3C(=C)C(C4C(O3)CCC5(O4)CCC(O5)C=CC(C)C6CC(=CC7(O6)C(CCC(O7)CC(C)(C(=O)O)O)O)C)O)O
Isomeric SMILES
C[C@@H]1CC[C@]2(CCCCO2)O[C@@H]1[C@@H](C)C[C@@H]([C@@H]3C(=C)[C@H]([C@H]4[C@H](O3)CC[C@]5(O4)CC[C@@H](O5)/C=C/[C@@H](C)[C@@H]6CC(=C[C@@]7(O6)[C@@H](CC[C@H](O7)C[C@](C)(C(=O)O)O)O)C)O)O
Solubility ( literature )

Reportedly, Okadaic acid is soluble in acetone, methanol, ethanol, chloroform or ethyl acetate.

Compound Classification

Polyether antibiotic

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Retest time
3 Years
Applications

Okadaic Acid is a potent non-TPA type tumor promoter and vasodilator. It induces hyperphosphorylation of the P53 oncoprotein

Ingredient type
Fermentek product
Available since
Title
Additional Transport Information:
Value
De Minimis Quantities exemption, per IATA 2.6.10 - applicable.
Title
Transpoprt information
Value
Pg III
Title
Storage considerations
Value
Some other sources recommend storing under inert gase
Fermentek Product Category
Research field: Cancer
Apoptosis related
Protein kinase related
DNA replication inhibitors
Research field: Signal Transduction
Others
Signal to sort
O

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$1.00
Okadaic_Acid.gif
Okadaic_Acid.gif

Mycophenolic acid

Mycophenolic acid
Molecular Formula
C17H20O6
M.W.
320.34
CAS number
24280-93-1
Source
Penicillium brevicompactum
Fermentek product Code
MPA-001
Brand/grade
For research
Appearance
White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
138°C-146°C
Solubility test
Clear colorless solution at 10mg/ml Methanol,
Clear colorless solution at 50mg/ml DMSO
EU number
246-119-3
Description

fatty acid antibiotic

InChl Key
HPNSFSBZBAHARI-RUDMXATFSA-N
Canonical SMILES
CC1=C(C(=C(C2=C1COC2=O)O)CC=C(C)CCC(=O)O)OC
Isomeric SMILES
CC1=C(C(=C(C2=C1COC2=O)O)C/C=C(\C)/CCC(=O)O)OC
Solubility ( literature )

DMSO, Ethanol, Methanol, Dichloromethane. Insoluble in water

Compound Classification

Immunosupressor

Purine nucleotide synthesis inhibitor

Retest time
3 Years
Ingredient type
Fermentek product
Title
toxicity oral mouse LD50
Value
1 gr/kg
Title
toxicity oral rat LD50
Value
352 mg/kg
Fermentek Product Category
Antibiotics
Immunomodulators
Others
Signal to sort
M

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Price
$1.00
Mycophenolic_acid.gif
Mycophenolic_acid.gif

Mycophenolate Mofetil

Mycophenolate Mofetil
Molecular Formula
C23H31NO7
M.W.
433.49
CAS number
128794-94-5
Source
synthetic
Fermentek product Code
MYM-001
Brand/grade
For research
Appearance
White powder
Purity by HPLC
≥95% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless solution at 50mg/ml DMSO
Names and identifiers

2-Morpholinoethyl (E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoate systematic name: 4-Hexenoic acid, 6-(1,3-dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-, 2-(4-morpholinyl)ethyl ester, (E)-

RTECS No : MP7746700

EU number
627-027-6
Description

Morpholinoethyl ester of Mycophenolic acid

InChl Key
RTGDFNSFWBGLEC-SYZQJQIISA-N
Canonical SMILES
CC1=C(C(=C(C2=C1COC2=O)O)CC=C(C)CCC(=O)OCCN3CCOCC3)
Solubility ( literature )

Acetone: freely soluble.Methanol: solubleEthanol: Sparingly solubleNeutral water: about 40 µg/mLWater acidified to pH 4: about 4 mg/ml

Compound Classification

Immunomodulator, Immunosuppressor

Storage, handling
-18°C
Retest time
3 Years
Ingredient type
Fermentek product
Available since
Title
Deleted CAS Numbers
Value
115007-34-6; 140401-05-4
Title
Transport information
Value
Not hazardous for transport
Fermentek Product Category
Antibiotics
Immunomodulators
Others
Signal to sort
M

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Price
$1.00
Mycophenolate_Mofetil.gif
Mycophenolate_Mofetil.gif

Leptomycin B

Leptomycin B
Molecular Formula
C33H48O6
M.W.
540.70
CAS number
87081-35-4
Source
Streptomyces sp.
Fermentek product Code
LPB-001
Brand/grade
For research
Appearance
Lyophilized powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless solution at 10mg/ml of Methanol
Names and identifiers

Synonyms: 

  • Elactocin
  • Mantuamycin
  • Antibiotic CI 940
  • Antibiotic CL 1957A

RTECS:      RA5390000

EU number
617-954-4
Description

Leptomycin B is an unsaturated, branched-chain fatty acid.

Until 4-jun-2018 Leptomycin had been offered by Fermentek in the form of 1% V/W solution in Methanol/Water mix. Since then, it is offered as lyophylizate.

InChl Key
YACHGFWEQXFSBS-XYERBDPFSA-N
Canonical SMILES
CCC(=CC(C)CC=CC(=CC(C)C(=O)C(C)C(C(C)CC(=CC(=O)O)C)O)C)C=CC1C(C=CC(=O)O1)C
Isomeric SMILES
CC/C(=C/[C@H](C)C/C=C/C(=C/[C@@H](C)C(=O)[C@@H](C)[C@@H]([C@@H](C)C/C(=C/C(=O)O)/C)O)/C)/C=C/[C@H]1[C@H](C=CC(=O)O1)C
Solubility ( literature )

Leptomycin B is soluble in ethanol, methanol.

Until 4-jun-2018, Fermentek supplied Leptomycin in form of 1% w/v solution in Methanol/water. Since 4-jun-2018 it is as a lyophylisate. 

Compound Classification

Fatty acid antibiotic

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Hygroscopic substance.
Protect from moisture
Retest time
2 Years
Applications

Leptomycin B is an important tool in the study of nuclear export. Leptomycin B is twice as potent as Leptomycin A Leptomycin B (LPB) was originally discovered as a potent anti-fungal antibiotic from Streptomyces sp. However, recent data (2003) showed that Leptomycin causes G1 cell cycle arrest in mammalian cells and is a potent anti-tumor agent against murine experimental tumors. Leptomycin B is a potent and specific nuclear export inhibitor. Leptomycin B alkylates and inhibits CRM1 (chromosomal region maintenance)/exportin 1, a protein required for nuclear export of proteins containing a nuclear export sequence (NES). In addition to antifungal and antibacterial activities, Leptomycin B blocks the cell cycle and is a potent anti-tumor agent. At low nM concentrations, Leptomycin B blocks the nuclear export of many proteins including HIV-1 Rev, MAPK/ERK, and NF-κB/IκB, and it stabilizes the expression of p53. Leptomycin B also inhibits the export and translation of many RNAs, including COX-2 and c-Fos mRNAs, by inhibiting export of ribonucleoproteins.

Disclaimer
Refer to MSDS for further safety and handling instructions.
Ingredient type
Fermentek product
Available since
Title
Deleted CAS Numbers
Value
94730-69-5
Title
Change notif 4-jun-2018
Value
Supplied as lyophilisate
Title
comments: safety
Value
The info regarding toxicity/flammability is about the methanol. We offer solid material.
Fermentek Product Category
Research field: Cancer
Protein synthesis inhibitors
Anti Fungal
Cancer Related Compounds
Research field: Signal Transduction
Others
Signal to sort
L

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Leptomycin_B.gif
Leptomycin_B.gif

KT5823

KT5823
Molecular Formula
C29H25N3O5
M.W.
495.53
CAS number
126643-37-6
Source
Semisynthetic
Fermentek product Code
KT5-002
Brand/grade
For research
Appearance
White solid
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless solution at 5mg/ml Ethyl acetate
EU number
603-150-0
Description

KT5823 is a potent, selective inhibitor of cGMP-dependent protein kinase (PKG)

InChl Key
QTYMDECKVKSGSM-UHFFFAOYSA-N
Canonical SMILES
CC12C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CN(C6=O)C)(C(=O)OC)OC
Solubility ( literature )

DMSO, Ethyl Acetate

Compound Classification

indolocarbazole alkaloidPKG inhibitor

Storage, handling
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Applications

KT5823 induces apoptotic fragmentation of DNA

Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Not hazardous for transport
Fermentek Product Category
Antibiotics
Enzyme-inhibitors
Protein kinase related
Research field: Signal Transduction
Others
Signal to sort
K

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Price
$1.00
KT5823.gif
KT5823.gif

KT5720

KT5720
Molecular Formula
C32H31N3O5
CAS number
108068-98-0
Source
Synthetic
Fermentek product Code
KT5-001
Brand/grade
For research
Appearance
White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
145°C-155°C
Solubility test
Clear colorless solution at 5mg/ml Methanol
EU number
810-587-2
Description

KT5720: A selective inhibitor of cAMP-dependent protein kinase (PKA)

InChl Key
ZHEHVZXPFVXKEY-UHFFFAOYSA-N
Canonical SMILES
CCCCCCOC(=O)C1(CC2N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N(C7=C53)C1(O2)C)CNC6=O)O
Isomeric SMILES
CCCCCCOC(=O)[C@]1(C[C@H]2N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N(C7=C53)[C@@]1(O2)C)CNC6=O)O
Solubility ( literature )

Soluble in methanol, DMSO

Compound Classification

indolocarbazole alkaloid

PKA inhibitor

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Hygroscopic substance.
Protect from moisture
Protect from light !
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Semi-Synthetic
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Not hazardous for transport
Fermentek Product Category
Antibiotics
Enzyme-inhibitors
Protein kinase related
Research field: Signal Transduction
Others
Signal to sort
K

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Price
$1.00
KT5720.gif
KT5720.gif

K252c

K252c
Molecular Formula
C20H13N3O
M.W.
311.40
CAS number
85753-43-1
Source
Nocardiopsis sp
Fermentek product Code
K2C-001
Brand/grade
For research
Appearance
Off-white to yellow powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless to light yellow solution at 7.8mg/ml DMSO (25mM)
Names and identifiers

Synonyms:

  • Staurosporine aglycone;
  • Staurosporinone.
  • K252C

 

Description

K252c: Cell permeable protein kinase inhibitor of the Staurosporine family (indolo[2,3-a]carbazole alkaloids)

InChl Key
MEXUTNIFSHFQRG-UHFFFAOYSA-N
Canonical SMILES
C1C2=C3C4=CC=CC=C4NC3=C5C(=C2C(=O)N1)C6=CC=CC=C6N5
Solubility ( literature )

Readily soluble in chloroform, acetonitrile, acetone, dioxane, tetrahydrofuran, pyridine;Soluble in ethanol, methanol, 1-propanol, ethyl acetate and n-butanol;Insoluble in water, 2-propanol. Comment: This information has been collected from available scientific sources. It is not a part of product specification

Compound Classification

indolocarbazole alkaloidPKC inhibitor

Storage, handling
-20oC. Protect from light. Hygroscopic. Protect from moisture
Retest time
3 Years
Applications

K252c inhibits protein kinase C. Its reported IC50 value of 214 nM on rat brain enzyme K252c is cytotoxic for A549 and P388 cancer celllines showing IC50 = 2-3 μM

Ingredient type
Fermentek product
Available since
Title
Transport information
Value
NDG
Fermentek Product Category
Antibiotics
Enzyme-inhibitors
Apoptosis related
Protein kinase related
Research field: Signal Transduction
Others
Signal to sort
K

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Price
$1.00
K252c.gif
K252c.gif

K252b

K252b
Molecular Formula
C26H19N3O5
M.W.
453.45
CAS number
99570-78-2
Source
Semisynthetic
Fermentek product Code
K2B-001
Brand/grade
For research
Appearance
white to light yellow powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
245°C-255°C
Solubility test
Clear colorless solution at 5mg/ml of Methanol
Names and identifiers

Synonyms:

  • Antibiotic K 252b
  • K 252b
  • KT 5556

 

 

 

Description

K252B: an inhibitor of protein kinase A, C, G

InChl Key
AMSOPBXQXSAAAC-PLZPTFKGSA-N
Canonical SMILES
CC12C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)(C(=O)O)O
Isomeric SMILES
C[C@@]12[C@](C[C@@H](O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)(C(=O)O)O
Solubility ( literature )

DMSO or Methanol

Compound Classification

Indolocarbazole alkaloid; 

PK inhibitor

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Hygroscopic substance.
Protect from moisture
Protect from light !
Retest time
3 Years
Ingredient type
Fermentek product
Available since
Title
Deleted CAS Numbers:
Value
107028-51-3
Title
Transport information
Value
NDG
Fermentek Product Category
Antibiotics
Enzyme-inhibitors
Apoptosis related
Protein kinase related
Research field: Signal Transduction
Others
Signal to sort
K

Quote for

Price
$1.00
K252b.gif
K252b.gif

K252a

K252a
Molecular Formula
C27H21N3O5
M.W.
467.47
CAS number
99533-80-9
Source
Nocardiopsis sp
Fermentek product Code
K2A-001
Brand/grade
For research
Appearance
White to pale yellow powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
255°C-270°C
Solubility test
Clear colorless to slight yellow solution at 50mg/ml of DMSO
Names and identifiers

RTECS NZ0550000

EU number
640-127-4
Description

K252a: Cell permeable protein kinase inhibitor

InChl Key
KOZFSFOOLUUIGY-IYYJOCMQSA-N
Canonical SMILES
CC12C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)(C(=O)OC)O
Isomeric SMILES
C[C@]12[C@@](C[C@H](O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)(C(=O)OC)O
Solubility ( literature )

Readily soluble in chloroform, acetonitrile, acetone, dioxane, tetrahydrofuran, pyridine;soluble in ethanol, methanol, 1-propanol, ethyl acetate and n-butanol; insoluble in water, 2-propanol

Compound Classification
  • indolocarbazole alkaloid
  • PK inhibitor
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from moisture
Protect from light !
Use the original container to store the product.
Keep the lid tightly closed.
Retest time
3 Years
Applications

K252a is a highly potent cell permeable inhibitor of CaM kinase and phosphorylase kinase . At high concentrations it also inhibitors of serine/threonine protein kinases. K252a inhibits tyrosine phosphorylation of Trk A induced by NGF K252a is reported to promote myogenic differentiation in C2 mouse myoblasts

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Title
Deleted CAS Numbers
Value
97161-97-2; 105450-17-7; 108645-76-7; 151004-74-9
Title
Transport information
Value
Not hazardous for transport
Fermentek Product Category
Antibiotics
Enzyme-inhibitors
Protein kinase related
Research field: Signal Transduction
Others
Signal to sort
K

Quote for

Price
$1.00
K252a.gif
K252a.gif
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