Netropsin 2HCl

Netropsin dihydrochloride
Molecular Formula
C18H26 N10O3·2HCl
M.W.
503.40
CAS number
18133-22-7
MSDS
Source
Streptomyces netropsis
Fermentek product Code
NE
Brand/grade
For research
Appearance
White to slight yellow powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
241°C-247°C
Solubility test
Clear colorless to slight yellow solution at 1mg/ml of H2O
Names and identifiers

Synonyms: 

  • Congocidin
  • Sinanomycin
  • Netropsin

IUPAC: N-{5-[(3-amino-3-iminopropyl)carbamoyl]-1-methyl-1H-pyrrol-3-yl}-4-{[N-(diaminomethylidene)glycyl]amino}-1-methyl-1H-pyrrole-2-carboxamide

RTECS DW2974000

EU number
634-294-2
Chemical name
Netropsin dihydrochloride
Description

A basic cytotoxic polypeptide from Streptomyces netropsis. Netropsin binds to A-T sequences of DNA.

InChl Key
QZOOZUGORDEYCC-UHFFFAOYSA-N
Canonical SMILES
CN1C=C(C=C1C(=O)NCCC(=O)N)NC(=O)C2=CC(=CN2C)N=C(CN=C(N)N)N.Cl
Compound Classification

Chemical  classification:

  • Pyrrole-amidine antibiotic
  • Oligopetptide antibiotic

Pharmaceutic classification

  • Antibacterial
  • Antiviral

    

 

 

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Protect from moisture!
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Customs: Other Antibiotics-29419000
Shipped at ambient temperature
Transport safety: Not Dangerous Goods; Not Regulated
Available since
Title
Naming and numbering problems
Value
There are ambiguities w/ CAS numbers, naming w/ hydride, chloride etc
Title
Deleted CAS Registry Numbers
Value
554-32-5 - very similar compound. | 1403-42-5, 47686-02-2 - perhaps misformed numbers
Signal to sort
N

Altertoxin I

Altertoxin I
Molecular Formula
C20H16O6
M.W.
352.34
CAS number
56258-32-3
MSDS
Source
Alternaria sp.
Fermentek product Code
ALX-001
Brand/grade
For research
Appearance
Off-White to yellowish powder
Purity by HPLC
≥95% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear slight yellow solution at 10mg/ml Methanol
Names and identifiers

Synonyms:

  • (12S,12As,12Br)-4,9,12,12B-Tetrahydroxy-2,11,12,12A-Tetrahydro-1H-Perylene-3,10-Quinone;
  • Altertoxin I
  • Altertoxin-I

Chemical names:

IUPAC:

  • (12S,12aS,12bR)-4,9,12,12b-tetrahydroxy-2,11,12,12a-tetrahydro-1H-perylene-3,10-dione

 

RTECS#   : BC9625200

Description

Altertoxin-1, a natural mycotoxin from Alternaria fungi, an important contaminant in cereals, vegetables.

InChl Key
GJIALGLHOBXNAT-KPOBHBOGSA-N
Canonical SMILES
C1CC2(C3C4C(O4)C(=O)C5=C(C=CC(=C35)C6=C2C(=C(C=C6)O)C1=O)O)O
Isomeric SMILES
C1C[C@]2([C@@H]3[C@H](CC(=O)C4=C(C=CC(=C34)C5=C2C(=C(C=C5)O)C1=O)O)O)O
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Applications

Altertoxin I (and other altertoxins) inhibit the HIV replication.

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
tsa
Value
V=veg fermentation
Title
classif
Value
cytotoxic; mutagenic
Signal to sort
A

T2 Toxin

Molecular Formula
C24H34O9
M.W.
466.52
CAS number
21259-20-1
MSDS
Source
Fusarium tricinctum
Fermentek product Code
T2T-001
Brand/grade
For research
Appearance
White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless solution at 5mg/ml Dichloromethane
Names and identifiers

Synonyms

  • Fusariotoxin T2
  • T2 TOXIN
  • MYCOTOXIN T2
  • 8-(3-Methylbutyryloxy)-diacetoxyscirpenol
  • Trichothec-9-ene-3.alpha.,8.alpha.,15-tetrol, 12,13-epoxy-, 4,15-diacetate 8-isovalerate

RTECS: YD0100000

 

EU number
244-297-7
Chemical name
T2 TOXIN
Description

T2 Toxin: A trichothecene group mycotoxin, of the most important Fusarium toxins.

InChl Key
BXFOFFBJRFZBQZ-QYWOHJEZSA-N
Canonical SMILES
CC1=CC2C(CC1OC(=O)CC(C)C)(C3(C(C(C(C34CO4)O2)O)OC(=O)C)C)COC(=O)C
Isomeric SMILES
CC1=C[C@@H]2[C@](C[C@@H]1OC(=O)CC(C)C)([C@]3([C@@H]([C@H]([C@H]([C@@]34CO4)O2)O)OC(=O)C)C)COC(=O)C
Solubility ( literature )

Dichloromethane, DMSO, Ethanol, Ethyl Acetate. Slightly soluble in petroleum ether; very slightly soluble in water.

Compound Classification

Trichothecene Mycotoxin

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Applications

T-2 toxin has been reported to be used to increase blood-brain barrier permeability in rats.

T-2 Toxin induces DNA damage and cell death on prolonged administration.

Ingredient type
Fermentek product
Available since
Title
Transport information
Value
PG I
Signal to sort
T

Puromycin Aminonucleoside

Puromycin Aminonucleoside
Molecular Formula
C12H18N6O3
M.W.
294.30
CAS number
58-60-6
MSDS
Source
Semisynthetic (from Puromycin)
Fermentek product Code
PAN-001
Brand/grade
For research
Appearance
White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
220°C-230°C
Solubility test
Clear colorless solution at 50 mg/ml DMSO;
Clear colorless solution at 10 mg/ml water
Names and identifiers

RTECS: AU7337000

EU number
200-387-8
Description

Puromycin Aminonucleoside is a puromycin analog which does not inhibit protein synthesis or induce apoptosis

InChl Key
MKSVFGKWZLUTTO-FZFAUISWSA-N
Canonical SMILES
CN(C)C1=NC=NC2=C1N=CN2C3C(C(C(O3)CO)NC(=O)C(CC4=CC=C(C=C4)OC)N)O.Cl.Cl
Isomeric SMILES
CN(C)C1=NC=NC2=C1N=CN2[C@H]3[C@@H]([C@@H]([C@H](O3)CO)NC(=O)[C@H](CC4=CC=C(C=C4)OC)N)O.Cl.Cl
Solubility ( literature )

Water

Compound Classification
  • Nucleoside antibiotic
  • Protein synthesis inhibitor

 

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Retest time
3 Years
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Semi-Synthetic
Ingredient type
Fermentek product
Available since
Title
Deleted CAS Numbers
Value
28315-29-9 ; 54833-68-0 ; 136680-68-7
Title
Transport information
Value
Not hazardous for transport
Signal to sort
P

Penicillic acid

Penicillic acid
Molecular Formula
C8H10O4
M.W.
170.16
CAS number
90-65-3
Source
Penicillium Cyclopium
Fermentek product Code
PEN-001
Brand/grade
For research
Appearance
white to light yellow powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless solution at 10mg/ ml Dichloromethane
Names and identifiers

Synonyms

  • 3-Methoxy-5-methyl-4-oxo-2,5-hexadienoic acid

HSDB 3523

RTECS  MM2625000

EU number
202-008-1
Chemical name
3-Methoxy-5-methyl-4-oxo-2,5-hexadienoic acid
Description

Penicillic acid is a polyketide mycotoxin which induces single and double strand DNA breaks. It inhibits GDP-mannose dehydrogenase. It inhibits also muscle aldose dehydrogenase, lactate dhydrogenase and alcohol dehydrogenase.

InChl Key
VOUGEZYPVGAPBB-XQRVVYSFSA-N
Canonical SMILES
CC(=C)C(=O)C(=CC(=O)O)OC
Isomeric SMILES
CC(=C)C(=O)/C(=C/C(=O)O)/OC
Solubility ( literature )

Water, Ethanol, Dichloromethane.

Compound Classification
  • Lactone Mycotoxin
  • Hexanoic Acid
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since

Okadaic Acid

Okadaic Acid
Molecular Formula
C44H68O13
M.W.
805.00
CAS number
78111-17-8
Source
Marine dinoflagellates
Fermentek product Code
OKA-001
Brand/grade
For research
Appearance
White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless solution at 5mg/ml EtOH;
Clear colorless solution at 40mg/ml DMSO
Names and identifiers

RTECS AA8227800

EU number
616-589-8
Chemical name
Acanthifolicin, 9,10-deepithio-9,10-didehydro-
Description

Inhibitor of protein phosphatase

InChl Key
QNDVLZJODHBUFM-WFXQOWMNSA-N
Canonical SMILES
CC1CCC2(CCCCO2)OC1C(C)CC(C3C(=C)C(C4C(O3)CCC5(O4)CCC(O5)C=CC(C)C6CC(=CC7(O6)C(CCC(O7)CC(C)(C(=O)O)O)O)C)O)O
Isomeric SMILES
C[C@@H]1CC[C@]2(CCCCO2)O[C@@H]1[C@@H](C)C[C@@H]([C@@H]3C(=C)[C@H]([C@H]4[C@H](O3)CC[C@]5(O4)CC[C@@H](O5)/C=C/[C@@H](C)[C@@H]6CC(=C[C@@]7(O6)[C@@H](CC[C@H](O7)C[C@](C)(C(=O)O)O)O)C)O)O
Solubility ( literature )

Reportedly, Okadaic acid is soluble in acetone, methanol, ethanol, chloroform or ethyl acetate.

Compound Classification

Polyether antibiotic

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Retest time
3 Years
Applications

Okadaic Acid is a potent non-TPA type tumor promoter and vasodilator. It induces hyperphosphorylation of the P53 oncoprotein

Ingredient type
Fermentek product
Available since
Title
Additional Transport Information:
Value
De Minimis Quantities exemption, per IATA 2.6.10 - applicable.
Title
Transpoprt information
Value
Pg III
Title
Storage considerations
Value
Some other sources recommend storing under inert gase
Signal to sort
O

Mithramycin A

Mithramycin A
Molecular Formula
C52H76O24
M.W.
1 085.00
CAS number
18378-89-7
MSDS
Source
Streptomyces argillaceus
Fermentek product Code
MTA-001
Brand/grade
For research
Appearance
Yellow powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
175°C-185°C
Solubility test
Clear yellowish solution at 100mg/ml DMSO
Names and identifiers

Synonyms:

  • Mithramycin
  • Plicamycin
  • Aureolic acid

RTECS: PZ2800000

EU number
634-048-4
Description

Oligosaccharide antibiotic, a RNA synthesis inhibitor.

InChl Key
CFCUWKMKBJTWLW-BKHRDMLASA-N
Canonical SMILES
CC1C(C(CC(O1)OC2CC(OC(C2O)C)OC3=CC4=CC5=C(C(=O)C(C(C5)C(C(=O)C(C(C)O)O)OC)OC6CC(C(C(O6)C)O)OC7CC(C(C(O7)C)O)OC8CC(C(C(O8)C)O)(C)O)C(=C4C(=C3C)O)O)O)O
Isomeric SMILES
C[C@@H]1[C@H]([C@@H](C[C@@H](O1)O[C@@H]2C[C@@H](O[C@@H]([C@H]2O)C)OC3=CC4=CC5=C(C(=O)[C@H]([C@@H](C5)[C@@H](C(=O)[C@H]([C@@H](C)O)O)OC)O[C@H]6C[C@H]([C@@H]([C@H](O6)C)O)O[C@H]7C[C@H]([C@H]([C@H](O7)C)O)O[C@H]8C[C@]([C@@H]([C@H](O8)C)O)(C)O)C(=C4C(=C3C)O)O)O)O
Solubility ( literature )

DMSO, Methanol, Ethanol

Compound Classification

Anthracycline Pentaglycosidic antibiotic.

RNA synthesis inhibitor

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from moisture
Avoid exposing to strong direct light.
Store under argon.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Applications

DNA binding fluorescent dye. Until 2000 it was used to reduce high levels of plasma calcium. Used as an antineoplastic agent in the treatment of testicular cancer, Paget's disease of bone, and, rarely, the management of hypercalcemia.

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Not dangerous goods
Title
Deleted CAS numbers
Value
1395-17-1; 1403-98-1; 12708-66-6; 12708-67-7; 23973-19-5; 97666-60-9; 219612-19-8; 744999-90-4; 807260-73-7; 826336-23-6; 899900-19-7; 1195235-16-5
Title
CN code
Value
29419000
Title
toxicity by RTECS
Value
LD50 oral mouse 500 mg/kg
Title
toxicity by RTECS
Value
TDLo oral human 50 ug/kg* 5D
Title
EPA USA status
Value
EPA GENETOX PROGRAM 1988, Positive: CHO gene mutation
Signal to sort
M

Deoxynivalenol

Deoxynivalenol (DON)
Molecular Formula
C15H20O6
M.W.
296.30
CAS number
51481-10-8
MSDS
Source
Semisynthetic
Fermentek product Code
DON-001
Brand/grade
For research
Appearance
White crystalline solid.
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
150°C-155°C
Solubility test
Clear colorless solution at 10mg/ml Methanol or Ethyl acetate

Names and identifiers
  • Rd toxin
  • Vomitoxin
  • Deoxynivalenol
  • 4-Deoxynivalenol
  • Dehydronivalenol
  • 4-Desoxynivalenol

RTECS YD0167000

EU number
610-668-0
Description

Deoxynivalenol (DON , Vomitoxin) is a type B trichothecene. It occurs in grains such as wheat, barley, oats, rye, and maize, rice, sorghum. Deoxynivalenol (DON ) is produced by numerous strains of Fusarium and some other fungi. Deoxynivalenol (DON ) poisonings occur both in humans and farm animals. Deoxynivalenol (DON ) is highly toxic, producing a wide range of immunological disturbances and is particularly noted for inducing feed refusal and emesis in pigs, hence the alternative name vomitoxin Deoxynivalenol (DON ) usually co-occurs with other Fusarium toxins, such as Zearalenone, Nivalenol and its derivates, as well as the group of fumonisins.

InChl Key
LINOMUASTDIRTM-QGRHZQQGSA-N
Canonical SMILES
CC1=CC2C(C(C1=O)O)(C3(CC(C(C34CO4)O2)O)C)CO
Isomeric SMILES
CC1=C[C@@H]2[C@]([C@@H](C1=O)O)([C@]3(C[C@H]([C@H]([C@@]34CO4)O2)O)C)CO
Solubility ( literature )

Deoxynivalenol (DON ) is soluble in common polar organic solvents as acetonitrile, methanol and ethyl acetate, slightly soluble in water.

Compound Classification

trichothecene type B mycotoxin

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from moisture
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Applications

The main toxic effect of Deoxynivalenol (DON ) is inhibition of protein synthesis via binding to the ribosome.In agricultural R&D, DON is widely used to select crops strains with increased resistance against Fusarium.

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Semi-Synthetic
Ingredient type
Fermentek product
Available since
Title
Deleted CAS Numbers
Value
50722-37-7 ; 115825-61-1 ; 1394244-12-2
Signal to sort
D

Aphidicolin

Aphidicolin
Molecular Formula
C20H34O4
M.W.
338.48
CAS number
38966-21-1
MSDS
Source
Nigrospora oryzae
Fermentek product Code
APH-001
Brand/grade
For research
Appearance
White to Off-White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
228°C-233°C
Solubility test
Clear colorless solution at 50mg/ml of DMSO, 10mg/ml of Methanol
Names and identifiers

 RTECS: PB9185000

EU number
609-602-3
Description

Aphidicolin is an antiviral antibiotic produced by Nigrospora oryzae and other fungi. Aphidicolin inhibits the growth of eukaryotic cells and certain animal viruses by selectively inhibiting the cellular replication of DNA polymerase II or the viral-induced DNA polymerases. The drug may be useful for controlling excessive cell proliferation in patients with cancer, psoriasis or other dermatitis, while having no effect on non-multiplying cells.

InChl Key
NOFOAYPPHIUXJR-APNQCZIXSA-N
Canonical SMILES
CC12CCC(C(C1CCC3C24CCC(C(C3)C4)(CO)O)(C)CO)O
Isomeric SMILES
C[C@]12CC[C@H]([C@@]([C@@H]1CC[C@@H]3[C@@]24CC[C@@]([C@H](C3)C4)(CO)O)(C)CO)O
Solubility ( literature )

Methanol, DMSO

Compound Classification

tetracyclic mycotoxin

DNA polymerase A inhibitor

Antiviral

Chemical classification:

  • A tetracyclic diterpene antibiotic.

Biological classification:

  • Antiviral, antimithotical
  • Specific inhibitor of DNA polymerase A

 

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Retest time
3 Years
Applications

Aphidicolin inhibits the growth of eukaryotic cells and certain animal viruses by selectively inhibiting the cellular replication of DNA polymerase II or the viral-induced DNA polymerases. The drug may be useful for controlling excessive cell proliferation in patients with cancer, psoriasis or other dermatitis with little or no adverse effect upon non-multiplying cells.Aphidicolin is a tool in cell proliferation and differentiation research. Aphidicolin may possibly be used for controlling excessive cell proliferation in cancer, psoriasis or other dermatitis with little or no adverse effect upon non-multiplying cells.

Disclaimer
Refer to MSDS for further safety and handling instructions.
Ingredient type
Fermentek product
Available since
Title
Additional Comments
Value
Elemental analysis may be performed for some lots
Title
Transport information
Value
Not hazardous for transport
Title
sig
Value
178273
Title
TSE
Value
F
Signal to sort
A

Alternariol monomethyl ether

Alternariol monomethyl ether
Molecular Formula
C15H12O5
M.W.
272.25
CAS number
23452-05-3
MSDS
Source
Alternaria alternata
Fermentek product Code
AME-001
Brand/grade
For research
Appearance
Off-white to light pink powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
255°C-270°C
Solubility test
Clear colorless solution at 1mg/ml Acetone.
Clear colorless solution at 1mg/ml Methanol (slight heating).
Names and identifiers

Alternate names

  • AME
  • Djalonensone
  • Alternariol monomethyl ether
  • Alternariol methyl ether
  • Alternariol-9-methyl ether

RTECS : HP8755000

EU number
636-657-0
Description

Alternariol monomethyl ether (AME) is a natural mycotoxin originated in Alternaria alternata fungi . It inhibits  Cholinesterase, and posesses  antifungal and phytotoxic properties.

InChl Key
LCSDQFNUYFTXMT-UHFFFAOYSA-N
Canonical SMILES
CC1=CC(=CC2=C1C3=CC(=CC(=C3C(=O)O2)O)OC)O
Solubility ( literature )

Soluble in DMSO, pure ethanol, methanol

Compound Classification

Pyrrolidinone mycotoxin

 

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Retest time
3 Years
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Non hazardous for shipment.
Available since
Title
Transport information
Value
Not hazardous for transport
Title
CAS number validated
Value
26894-49-5; 641-38-3
Title
Deleted CAS Numbers
Value
31273-73-1; 916665-00-4; 11003-13-7
Signal to sort
A