Ascomycin

Molecular Formula

C43H69NO12

M.W.

792.01

CAS number

104987-12-4

Details

Source

Streptomyces hygroscopicus subsp. ascomyceticus

Fermentek product Code

ASC-001

Brand/grade

For research

Specifications

Appearance

White powder

Purity by HPLC

≥98% ; refer to CoA for more data

Purity By TLC

≥98% ; refer to CoA for more data

Melting point

159°C-164°C

Solubility test

Ascomycin gives clear colorless solution at 10mg/ml Ethyl Acetate or 10mg/ml DMSO

Chemical identification

Names and identifiers

Synonyms

Immunomycin
FK520

RTECS KD4185000

EU number

435-850-5

Description

Ascomycin, also known as FK520, is a potent immunosuppressant.

Ascomycin inhibits allogenic T-lymphocyte proliferation.

InChl Key

ZDQSOHOQTUFQEM-PKUCKEGBSA-N

Canonical SMILES

CCC1C=C(CC(CC(C2C(CC(C(O2)(C(=O)C(=O)N3CCCCC3C(=O)OC(C(C(CC1=O)O)C)C(=CC4CCC(C(C4)OC)O)C)O)C)OC)OC)C)C

Isomeric SMILES

CC[C@@H]1/C=C(\C[C@@H](C[C@@H]([C@@H]2[C@H](C[C@H]([C@@](O2)(C(=O)C(=O)N3CCCC[C@H]3C(=O)O[C@@H]([C@@H]([C@H](CC1=O)O)C)/C(=C/[C@@H]4CC[C@H]([C@@H](C4)OC)O)/C)O)C)OC)OC)C)/C

Further Information

Solubility ( literature )

DMSO, Methanol, Ethanol, EtOAc (Ethyl Acetate)

Compound Classification

macrolide
immunosuppressant

Storage, handling

Store in a freezer upon arrival, at -10°C to -25°C

Hygroscopic substance.

Protect from moisture

Avoid exposing to strong direct light.

Retest time

3 Years

Applications

Ascomycin is used in the research of immunological phenomena, such as organs transplantation, allergy, and the like. To our best knowledge, Ascomycin is neither used nor approved for clinical use of any kind, although related or similar compounds might serve as drug components. Specifically, Ascomycin from Fermentek is has no pharmacological use whatsoever. It is only offered for research, to universities and other research embodiments, to be used by qualified scientists only.

Disclaimer

For Research use only

Not for Human or Drug use

Not extracted from humans or animals

Refer to MSDS for further safety and handling instructions

Composition

Ingredient type

Fermentek product

Supply related information

Shipped at ambient temperature

Transport safety: Not Dangerous Goods; Not Regulated

Special Info