Protein kinases are enzymes that modify other proteins by chemically adding phosphate groups to them (phosphorylation).

Phosphorylation usually results in a functional biological change of the target protein by changing enzyme activity, cellular location, or association with other proteins.

Protein kinases are a major factor in regulating most of the cellular control and signal transduction pathways. Protein kinase modifying reagents are therefore important both in cancer research and as drug candidates.

K252b

K252b
Molecular Formula
C26H19N3O5
M.W.
453.45
CAS number
99570-78-2
Source
Semisynthetic
Fermentek product Code
K2B-001
Brand/grade
For research
Appearance
white to light yellow powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
245°C-255°C
Solubility test
Clear colorless solution at 5mg/ml of Methanol
Names and identifiers

Synonyms:

  • Antibiotic K 252b
  • K 252b
  • KT 5556

 

 

 

Description

K252B: an inhibitor of protein kinase A, C, G

InChl Key
AMSOPBXQXSAAAC-PLZPTFKGSA-N
Canonical SMILES
CC12C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)(C(=O)O)O
Isomeric SMILES
C[C@@]12[C@](C[C@@H](O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)(C(=O)O)O
Solubility ( literature )

DMSO or Methanol

Compound Classification

Indolocarbazole alkaloid; 

PK inhibitor

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Hygroscopic substance.
Protect from moisture
Protect from light !
Retest time
3 Years
Ingredient type
Fermentek product
Available since
Title
Deleted CAS Numbers:
Value
107028-51-3
Title
Transport information
Value
NDG
Fermentek Product Category
Antibiotics
Enzyme-inhibitors
Apoptosis related
Protein kinase related
Research field: Signal Transduction
Others
Signal to sort
K

Quote for

Price
$1.00
K252b.gif
K252b.gif

K252a

K252a
Molecular Formula
C27H21N3O5
M.W.
467.47
CAS number
99533-80-9
Source
Nocardiopsis sp
Fermentek product Code
K2A-001
Brand/grade
For research
Appearance
White to pale yellow powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
255°C-270°C
Solubility test
Clear colorless to slight yellow solution at 50mg/ml of DMSO
Names and identifiers

RTECS NZ0550000

EU number
640-127-4
Description

K252a: Cell permeable protein kinase inhibitor

InChl Key
KOZFSFOOLUUIGY-IYYJOCMQSA-N
Canonical SMILES
CC12C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)(C(=O)OC)O
Isomeric SMILES
C[C@]12[C@@](C[C@H](O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)(C(=O)OC)O
Solubility ( literature )

Readily soluble in chloroform, acetonitrile, acetone, dioxane, tetrahydrofuran, pyridine;soluble in ethanol, methanol, 1-propanol, ethyl acetate and n-butanol; insoluble in water, 2-propanol

Compound Classification
  • indolocarbazole alkaloid
  • PK inhibitor
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from moisture
Protect from light !
Use the original container to store the product.
Keep the lid tightly closed.
Retest time
3 Years
Applications

K252a is a highly potent cell permeable inhibitor of CaM kinase and phosphorylase kinase . At high concentrations it also inhibitors of serine/threonine protein kinases. K252a inhibits tyrosine phosphorylation of Trk A induced by NGF K252a is reported to promote myogenic differentiation in C2 mouse myoblasts

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Title
Deleted CAS Numbers
Value
97161-97-2; 105450-17-7; 108645-76-7; 151004-74-9
Title
Transport information
Value
Not hazardous for transport
Fermentek Product Category
Antibiotics
Enzyme-inhibitors
Protein kinase related
Research field: Signal Transduction
Others
Signal to sort
K

Quote for

Price
$1.00
K252a.gif
K252a.gif

Hypericin

Hypericin
Molecular Formula
C30H16O8
M.W.
504.44
CAS number
548-04-9
Source
Hypericium perforatum (plant extract)
Fermentek product Code
HYP-001
Brand/grade
For research
Appearance
Blue – black powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear red solution at 10mg/ml DMSO
Names and identifiers
  • Cyclo-Werrol
EU number
208-941-0
Description

Natural antidepressant. Anti-retroviral agent. A protein kinaze-C inhibitor.

InChl Key
BTXNYTINYBABQR-UHFFFAOYSA-N
Canonical SMILES
CC1=CC(=C2C3=C1C4=C5C(=C(C=C4C)O)C(=O)C6=C(C=C(C7=C6C5=C3C8=C7C(=CC(=C8C2=O)O)O)O)O)O
Solubility ( literature )

Soluble in alkaline aqueous solutions. Soluble in organic bases such as pyridine (red fluorescent solutions) but not in other organic solvents

Compound Classification
  • Perylene analog.
  • Anthraquinone derivative
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Retest time
3 Years
Applications

Antidepressant. Apoptosis inducer. PKC inhibitor. Antiviral

Disclaimer
Refer to MSDS for further safety and handling instructions.
Ingredient type
Fermentek product
Available since
Title
Deleted CAS numbers
Value
345224-62-6; 693273-27-7;935869-37-7
Title
Transport information
Value
Not hazardous for transport
Fermentek Product Category
Plant-derived
Research field: Cancer
Protein kinase related
Anti Viral
Cancer Related Compounds
Immunosupressors
Immunomodulators
Signal to sort
H

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Price
$1.00
Hypericin.gif
Hypericin.gif

Chelerythrine chloride

Chelerythrine chloride
Molecular Formula
C21H18NO4∙Cl
M.W.
383.82
CAS number
3895-92-9
Source
Chelidonium majus
Fermentek product Code
CHE-001
Brand/grade
For research
Appearance
Yellow powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
202°C-208°C
Solubility test
Clear yellowish solution at 5mg/ml Methanol
Names and identifiers

EINECS 223-444-9

1,2-Dimethoxy-12-methyl(1,3)benzodioxolo(5,6-c)phenanthridinium chloride

Chelerythrine hydrochloride

EU number
223-444-9
Description

Chelerythrine: A benzophenanthridine alkaloid. A potent, selective, and cell-permeable PKC inhibitor.Chelerythrine is very closely related to sanguinarine. Unlike sanguinarine which is found in the green biomass of Chelidonium, Chelerythrine mainly occurs in its roots.

InChl Key
WEEFNMFMNMASJY-UHFFFAOYSA-M
Canonical SMILES
C[N+]1=C2C(=C3C=CC(=C(C3=C1)OC)OC)C=CC4=CC5=C(C=C42)OCO5.[Cl-]
Solubility ( literature )

Methanol, Water, DMSO

Compound Classification

Benzophenanthridine alkaloid

PKC inhibitor

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Retest time
3 Years
Ingredient type
Fermentek product
Available since
Title
Oral Toxicity Mouse
Value
No data.
Title
Transport safety information
Value
Not hazardous for transport
Fermentek Product Category
Plant-derived
Enzyme-inhibitors
Protein kinase related
Research field: Signal Transduction
Signal to sort
C

Quote for

Price
$1.00
Chelerythrine_Chloride.gif
Chelerythrine_Chloride.gif
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