Protein kinases are enzymes that modify other proteins by chemically adding phosphate groups to them (phosphorylation).

Phosphorylation usually results in a functional biological change of the target protein by changing enzyme activity, cellular location, or association with other proteins.

Protein kinases are a major factor in regulating most of the cellular control and signal transduction pathways. Protein kinase modifying reagents are therefore important both in cancer research and as drug candidates.

Staurosporine

Staurosporine
Molecular Formula
C28H26N4O3
M.W.
466.53
CAS number
62996-74-1
MSDS
Source
Streptomyces staurosporeus
Fermentek product Code
STA-001
Appearance
Off-white to light yellow powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
255°C-275°C
Solubility test
Clear colorless solution at 5mg/ml Ethyl Acetate,
Clear yellow solution at 25mg/ml DMSO
Names and identifiers

Synonyms:  Antibiotic AM 2282; 

RTECS: KD5084000   ;  attention: This RTECS record belongs to the Hydrochloride salt of Staurosporine, rather than the free base form.

EU number
613-127-7
Chemical name
Staurosporine
Description

Staurosporine is a cell permeable inhibitor of protein kinases, including protein kinase-C.   Inhibitor of nuclear factor kappa B kinase beta subunit.

InChl Key
HKSZLNNOFSGOKW-FYTWVXJKSA-N
Canonical SMILES
CC12C(C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)NC)OC
Isomeric SMILES
C[C@@]12[C@@H]([C@@H](C[C@@H](O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)NC)OC
Solubility ( literature )

DMSO, Methanol, Ethanol, Ethyl Acetate. Water insoluble

Compound Classification
  • Chemical classification: Indolocarbazole alkaloid
  • Bio-activity: PKC inhibitor
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Applications
  • Pharmacological tool to study signal transduction pathways, tyrosine phosphorylation and to induce apoptosis.
  • May participate in antigen-induced T-cell activation;
  • Affects Proto-oncogene serine/threonine-protein kinase Pim-1, T-cell-specific kinase, Tyrosine-protein kinase SYK, MAP kinase-activated protein kinase 2
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Shipped at ambient temperature
Shipped in PP / PE bottle.
Available since
Title
Transport information
Value
Not hazardous for transport
Title
Deleted CAS numbers
Value
109189-95-9
Title
Safety comments
Value
Others say it is cancerogen, explosive. We think, because theirs contains ligroyin.
Title
identity comments
Value
HCl salt thereof: C28-H26-N4-O3.Cl-H ; RTECS KD5084000;
Fermentek Product Category
Antibiotics
Enzyme-inhibitors
Research field: Cancer
Apoptosis related
Protein kinase related
Anti Fungal
Cancer Related Compounds
Anti Tumor agents
Research field: Signal Transduction
Signal to sort
S

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Stauprimide

Stauprimide
Molecular Formula
C35H28N4O4
M.W.
584.62
CAS number
154589-96-5
Source
Semisynthetic
Fermentek product Code
STP-001
Brand/grade
For research
Appearance
Yellow powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
230°C-237°C
Solubility test
Clear yellow solution at 10mg/ml of DMSO, Clear yellow solution at 5mg/ml of Methanol
Names and identifiers

chemical name:

N-Benzoyl-7-oxostaurosporine

 

Description

Promoter of stem cells differentiation;

InChl Key
MQCCJEYZKWZQHU-MPRCCEKMSA-N
Canonical SMILES
CC12C(C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)C(=O)NC6=O)N(C)C(=O)C9=CC=CC=C9)OC
Isomeric SMILES
C[C@@]12[C@@H]([C@@H](C[C@@H](O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)C(=O)NC6=O)N(C)C(=O)C9=CC=CC=C9)OC
Solubility ( literature )

Reportedly, Stauprimide is soluble in methanol, DMSO. Other sources mention ethanol (slightly), DMF, water (limited) and report 10% solutions in DMSO (100 mg/ml),

Compound Classification
  • Carbazole Antibiotic
  • Staurosporine derivative (from MeSH)
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend +2 to +8°C storage, room temperature, desication etc.
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Semi-Synthetic
Ingredient type
Fermentek product
Usually packed in amber-glass vials, 1 ml; capped with teflon lined plastic caps
Available since
Title
Transport information
Value
Not hazardous for transport
Fermentek Product Category
Research field: Cancer
Protein kinase related
Research field: Signal Transduction
Others
Signal to sort
S

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Price
$1.00

Radicicol

Radicicol
Molecular Formula
C18H17O6Cl
M.W.
364.78
CAS number
12772-57-5
Source
Humicola grisea
Fermentek product Code
RAD-001
Brand/grade
For research
Appearance
white to light yellow powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
190°C-199°C
Solubility test
Clear colorless solution at 20mg/ml DMSO
Names and identifiers

Synonyms:

  • Monorden
  • (2Z,4E)-8-chloro-9,11-dihydroxy-14-methyl-1a,14,15,15a-tetrahydro-6H-oxireno[e][2]benzoxacyclotetradecine-6,12(7H)-dione

RTECS: RR1105000

EU number
642-889-3
Description

Radicicol is a macrolactone antibiotic. Radicicol is a tyrosine kinase inhibitor. It displays anti-angiogenic activity.

InChl Key
YZWZEOGROVVHK-GTMNPGAYSA-N
Canonical SMILES
CC1CC2C(O2)C=CC=CC(=O)CC3=C(C(=CC(=C3Cl)O)O)C(=O)O1
Isomeric SMILES
C[C@@H]1C[C@@H]2[C@H](O2)/C=C\C=C\C(=O)CC3=C(C(=CC(=C3Cl)O)O)C(=O)O1
Solubility ( literature )

Methanol, Ethanol, DMSO.

Compound Classification
  • macrolactone
  • tyrosine kinase inhibitor
  • angiogeniesis inhibitor
  • HSP90 inhibitor
  • Anti fungal
  •  
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Avoid exposing to strong direct light.
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Fermentek Product Category
Antibiotics
Enzyme-inhibitors
HSP90 inhibitors
Angiogenesis related
Protein kinase related
Anti Fungal
Anti Protozoal
Signal to sort
R

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Price
$1.00

PKC412

PKC412 (Midostaurin)
Molecular Formula
C35H30N4O4
M.W.
570.60
CAS number
120685-11-2
Source
Synthetic
Fermentek product Code
PKC-001
Brand/grade
For research
Appearance
White to off-white powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
225°C-235°C
Solubility test
Clear colorless solution at 10mg/ml DMSO; Clear colorless solution at 5mg/ml methanol
Names and identifiers

Synonyms:

  • Midostaurin
  • PKC412
  • Benzoylstaurosporine
  • 4'-N-Benzoylstaurosporine

Commercial names: 

  • Rydapt

RTECS: CV5045180

Chemical name
4'-N-benzoyl staurosporine
Description

PKC412 (Midostaurin) is a cell permeable inhibitor of protein kinases, including protein kinase-C.

InChl Key
BMGQWWVMWDBQGC-UHFFFAOYSA-N
Canonical SMILES
CC12C(C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)N(C)C(=O)C9=CC=CC=C9)OC
Solubility ( literature )

Soluble in DMSO, Dichloromethane.
Water solubility : < 0.1 mg/1

Compound Classification
  • indolocarbazole alkaloid
  • PKC inhibitor
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Protect from moisture! Hygroscopic substance.
Applications
  • PKC412 is mentioned as a specific treatment for Myeloproliferative Disease (MPD)
  • PKC412 selectively inhibits protein kinase C (PKC)
  • Investigated for use/treatment in adult patients with high-risk acute myeloid leukemia (AML)
Disclaimer
Semi-Synthetic.
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Not hazardous for transport
Fermentek Product Category
Research field: Cancer
Angiogenesis related
Protein kinase related
Cancer Related Compounds
Research field: Signal Transduction
Others
Signal to sort
P

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Price
$1.00

Parthenolide

Parthenolide
Molecular Formula
C15H20O3
M.W.
248.32
CAS number
20554-84-1
Source
Tanacetum parthenium
Fermentek product Code
PAR-001
Brand/grade
For research
Appearance
White crystalline solid.
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
112°C-118°C
Solubility test
Clear colorless solution at 50mg/ml Dichloromethane; Clear colorless solution at 50mg/ml DMSO
Names and identifiers

IUPAC name: (1aR,4E,7aS,10aS,10bS)-1a,5-Dimethyl-8-methylene-2,3,6,7,7a,8,10a,10b-octahydrooxireno[9,10]cyclodeca[1,2-b]furan-9(1aH)-one

RTECS: LY4220000

EU number
692-532-0
Chemical name
Parthenolide
Description

Parthenolide is a sesquiterpene lactone and active principle of feverfew (Chrysanthemum parthenium)

InChl Key
KTEXNACQROZXEV-PVLRGYAZSA-N
Canonical SMILES
CC1=CCCC2(C(O2)C3C(CC1)C(=C)C(=O)O3)C
Isomeric SMILES
C/C/1=C\CC[C@@]2([C@H](O2)[C@@H]3[C@@H](CC1)C(=C)C(=O)O3)C
Solubility ( literature )

DMSO (100 mg/ml), Ethanol (20 mg/ml), Dichloromethane.

Compound Classification
  • sesquiterpene lactone

MAP kinase inhibitor

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Other vendors may recommend +2 to +8°C storage.
Applications

Parthenolide has anti-inflammatory, antisecretory and spasmolytic activity. It Inhibits the release of various mediators. It inhibits activation of MAP kinase.

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Not hazardous for transport
Fermentek Product Category
Plant-derived
Antibiotics
Research field: Cancer
Protein kinase related
Research field: Signal Transduction
Signal to sort
P

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$1.00

Okadaic Acid

Okadaic Acid
Molecular Formula
C44H68O13
M.W.
805.00
CAS number
78111-17-8
Source
Marine dinoflagellates
Fermentek product Code
OKA-001
Brand/grade
For research
Appearance
White powder
Purity by HPLC
≥90% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless solution at 5mg/ml EtOH;
Clear colorless solution at 40mg/ml DMSO
Names and identifiers

RTECS AA8227800

EU number
616-589-8
Chemical name
Acanthifolicin, 9,10-deepithio-9,10-didehydro-
Description

Inhibitor of protein phosphatase

InChl Key
QNDVLZJODHBUFM-WFXQOWMNSA-N
Canonical SMILES
CC1CCC2(CCCCO2)OC1C(C)CC(C3C(=C)C(C4C(O3)CCC5(O4)CCC(O5)C=CC(C)C6CC(=CC7(O6)C(CCC(O7)CC(C)(C(=O)O)O)O)C)O)O
Isomeric SMILES
C[C@@H]1CC[C@]2(CCCCO2)O[C@@H]1[C@@H](C)C[C@@H]([C@@H]3C(=C)[C@H]([C@H]4[C@H](O3)CC[C@]5(O4)CC[C@@H](O5)/C=C/[C@@H](C)[C@@H]6CC(=C[C@@]7(O6)[C@@H](CC[C@H](O7)C[C@](C)(C(=O)O)O)O)C)O)O
Solubility ( literature )

Reportedly, Okadaic acid is soluble in acetone, methanol, ethanol, chloroform or ethyl acetate.

Compound Classification

Polyether antibiotic

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Applications

Okadaic Acid is a potent non-TPA type tumor promoter and vasodilator. It induces hyperphosphorylation of the P53 oncoprotein

Ingredient type
Fermentek product
Available since
Title
Additional Transport Information:
Value
De Minimis Quantities exemption, per IATA 2.6.10 - applicable.
Title
Transpoprt information
Value
Pg III
Title
Storage considerations
Value
Some other sources recommend storing under inert gase
Fermentek Product Category
Research field: Cancer
Apoptosis related
Protein kinase related
DNA replication inhibitors
Research field: Signal Transduction
Others
Signal to sort
O

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Price
$1.00

KT5823

KT5823
Molecular Formula
C29H25N3O5
M.W.
495.53
CAS number
126643-37-6
Source
Semisynthetic
Fermentek product Code
KT5-002
Brand/grade
For research
Appearance
White solid
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless solution at 5mg/ml Ethyl acetate
EU number
603-150-0
Description

KT5823 is a potent, selective inhibitor of cGMP-dependent protein kinase (PKG)

InChl Key
QTYMDECKVKSGSM-UHFFFAOYSA-N
Canonical SMILES
CC12C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CN(C6=O)C)(C(=O)OC)OC
Solubility ( literature )

DMSO, Ethyl Acetate

Compound Classification

indolocarbazole alkaloidPKG inhibitor

Storage, handling
Other vendors may recommend higher temperatures for storage.
Applications

KT5823 induces apoptotic fragmentation of DNA

Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Not hazardous for transport
Fermentek Product Category
Antibiotics
Enzyme-inhibitors
Protein kinase related
Research field: Signal Transduction
Others
Signal to sort
K

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Price
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KT5720

KT5720
Molecular Formula
C32H31N3O5
CAS number
108068-98-0
Source
Synthetic
Fermentek product Code
KT5-001
Brand/grade
For research
Appearance
White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
145°C-155°C
Solubility test
Clear colorless solution at 5mg/ml Methanol
EU number
810-587-2
Description

KT5720: A selective inhibitor of cAMP-dependent protein kinase (PKA)

InChl Key
ZHEHVZXPFVXKEY-UHFFFAOYSA-N
Canonical SMILES
CCCCCCOC(=O)C1(CC2N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N(C7=C53)C1(O2)C)CNC6=O)O
Isomeric SMILES
CCCCCCOC(=O)[C@]1(C[C@H]2N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N(C7=C53)[C@@]1(O2)C)CNC6=O)O
Solubility ( literature )

Soluble in methanol, DMSO

Compound Classification

indolocarbazole alkaloid

PKA inhibitor

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Hygroscopic substance.
Protect from moisture
Protect from light !
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Semi-Synthetic
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Not hazardous for transport
Fermentek Product Category
Antibiotics
Enzyme-inhibitors
Protein kinase related
Research field: Signal Transduction
Others
Signal to sort
K

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Price
$1.00

K252c

K252c
Molecular Formula
C20H13N3O
M.W.
311.40
CAS number
85753-43-1
Source
Nocardiopsis sp
Fermentek product Code
K2C-001
Brand/grade
For research
Appearance
Off-white to yellow powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless to light yellow solution at 7.8mg/ml DMSO (25mM)
Names and identifiers

Synonyms:

  • Staurosporine aglycone;
  • Staurosporinone.
  • K252C

 

Description

K252c: Cell permeable protein kinase inhibitor of the Staurosporine family (indolo[2,3-a]carbazole alkaloids)

InChl Key
MEXUTNIFSHFQRG-UHFFFAOYSA-N
Canonical SMILES
C1C2=C3C4=CC=CC=C4NC3=C5C(=C2C(=O)N1)C6=CC=CC=C6N5
Solubility ( literature )

Readily soluble in chloroform, acetonitrile, acetone, dioxane, tetrahydrofuran, pyridine;Soluble in ethanol, methanol, 1-propanol, ethyl acetate and n-butanol;Insoluble in water, 2-propanol. Comment: This information has been collected from available scientific sources. It is not a part of product specification

Compound Classification

indolocarbazole alkaloidPKC inhibitor

Storage, handling
-20oC. Protect from light. Hygroscopic. Protect from moisture
Applications

K252c inhibits protein kinase C. Its reported IC50 value of 214 nM on rat brain enzyme K252c is cytotoxic for A549 and P388 cancer celllines showing IC50 = 2-3 μM

Ingredient type
Fermentek product
Available since
Title
Transport information
Value
NDG
Fermentek Product Category
Antibiotics
Enzyme-inhibitors
Apoptosis related
Protein kinase related
Research field: Signal Transduction
Others
Signal to sort
K

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Price
$1.00

K252b

K252b
Molecular Formula
C26H19N3O5
M.W.
453.45
CAS number
99570-78-2
Source
Semisynthetic
Fermentek product Code
K2B-001
Brand/grade
For research
Appearance
white to light yellow powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
245°C-255°C
Solubility test
Clear colorless solution at 5mg/ml of Methanol
Names and identifiers

Synonyms:

  • Antibiotic K 252b
  • K 252b
  • KT 5556

 

 

 

Description

K252B: an inhibitor of protein kinase A, C, G

InChl Key
AMSOPBXQXSAAAC-PLZPTFKGSA-N
Canonical SMILES
CC12C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)(C(=O)O)O
Isomeric SMILES
C[C@@]12[C@](C[C@@H](O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)(C(=O)O)O
Solubility ( literature )

DMSO or Methanol

Compound Classification

Indolocarbazole alkaloid; 

PK inhibitor

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Hygroscopic substance.
Protect from moisture
Protect from light !
Ingredient type
Fermentek product
Available since
Title
Deleted CAS Numbers:
Value
107028-51-3
Title
Transport information
Value
NDG
Fermentek Product Category
Antibiotics
Enzyme-inhibitors
Apoptosis related
Protein kinase related
Research field: Signal Transduction
Others
Signal to sort
K

Quote for

Price
$1.00
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