Bleomycin sulfate

Molecular Formula

C55H85N17O25S4

M.W.

1 512.62

CAS number

9041-93-4

MSDS

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Details

Source

Streptomyces verticillus

Fermentek product Code

BLE-001

Brand/grade

For research

Specifications

Appearance

White to slight yellow powder

Purity by HPLC

≥95% (complex of A2, B2) ; refer to CoA for more data

Purity By TLC

≥98% ; refer to CoA for more data

Melting point

188-205°C

Solubility test

Clear colorless solution at 20mg/ml of Water,
Clear colorless solution at 20mg/ml of DMSO

Chemical identification

Names and identifiers

Synonyms:

Blenoxane
Bleomycin B2
BLEOcell

Chemical names:

Bleomycin Sulfate (A mixture of bleomycin sulfate salts)

RTECS# EC5991990

EU number

232-925-2

Description

A non-ribosomal glycopeptide antitumor antibiotic which produces single and double-strand DNA breaks in tumor cells thus interrupting their cell cycle; has been used for the treatment of Hodgkin’s lymphoma in combination with doxorubicin, squamous cell carcinomas, testicular cancer, as well as in animal models of pulmonary fibrosis.

InChl Key

WUIABRMSWOKTOF-OCBSMOPSSA-N

Canonical SMILES

CC1=C(N=C(N=C1N)C(CC(=O)N)NCC(C(=O)N)N)C(=O)NC(C(C2=CN=CN2)OC3C(C(C(C(O3)CO)O)O)OC4C(C(C(C(O4)CO)O)OC(=O)N)O)C(=O)NC(C)C(C(C)C(=O)NC(C(C)O)C(=O)NCCC5=NC(=CS5)C6=NC(=CS6)C(=O)NCCC[S+](C)C)O.OS(=O)(=O)[O-]

Isomeric SMILES

CC1=C(N=C(N=C1N)C(CC(=O)N)NCC(C(=O)N)N)C(=O)NC(C(C2=CN=CN2)O[C@H]3[C@H]([C@H]([C@@H]([C@@H](O3)CO)O)O)O[C@@H]4[C@H]([C@H]([C@@H]([C@H](O4)CO)O)OC(=O)N)O)C(=O)NC(C)C(C(C)C(=O)NC(C(C)O)C(=O)NCCC5=NC(=CS5)C6=NC(=CS6)C(=O)NCCC[S+](C)C)O.OS(=O)(=O)[O-]

Further Information

Solubility ( literature )

Solubility in water 10 mg/ml; other sources: H2O: 20 mg/mL

Compound Classification