Bleomycin sulfate
Molecular Formula
C55H85N17O25S4
M.W.
1 512.62
CAS number
9041-93-4
MSDS
Source
Streptomyces verticillus
Fermentek product Code
BLE-001
Brand/grade
For research
Appearance
White to slight yellow powder
Purity by HPLC
≥95% (complex of A2, B2) ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
188-205°C
Solubility test
Clear colorless solution at 20mg/ml of Water,
Clear colorless solution at 20mg/ml of DMSO
Names and identifiers

Synonyms:

  • Blenoxane
  • Bleomycin B2
  • BLEOcell

Chemical names:

  • Bleomycin Sulfate (A mixture of bleomycin sulfate salts)

RTECS#     EC5991990

 
EU number
232-925-2
Description

A non-ribosomal glycopeptide antitumor antibiotic which produces single and double-strand DNA breaks in tumor cells thus  interrupting their cell cycle; has been used for the treatment of Hodgkin’s lymphoma in combination with doxorubicin, squamous cell carcinomas, testicular cancer, as well as in animal models of pulmonary fibrosis.

InChl Key
WUIABRMSWOKTOF-OCBSMOPSSA-N
Canonical SMILES
CC1=C(N=C(N=C1N)C(CC(=O)N)NCC(C(=O)N)N)C(=O)NC(C(C2=CN=CN2)OC3C(C(C(C(O3)CO)O)O)OC4C(C(C(C(O4)CO)O)OC(=O)N)O)C(=O)NC(C)C(C(C)C(=O)NC(C(C)O)C(=O)NCCC5=NC(=CS5)C6=NC(=CS6)C(=O)NCCC[S+](C)C)O.OS(=O)(=O)[O-]
Isomeric SMILES
CC1=C(N=C(N=C1N)C(CC(=O)N)NCC(C(=O)N)N)C(=O)NC(C(C2=CN=CN2)O[C@H]3[C@H]([C@H]([C@@H]([C@@H](O3)CO)O)O)O[C@@H]4[C@H]([C@H]([C@@H]([C@H](O4)CO)O)OC(=O)N)O)C(=O)NC(C)C(C(C)C(=O)NC(C(C)O)C(=O)NCCC5=NC(=CS5)C6=NC(=CS6)C(=O)NCCC[S+](C)C)O.OS(=O)(=O)[O-]
Solubility ( literature )

Solubility in water 10 mg/ml; other sources: H2O: 20 mg/mL

Compound Classification
  • Chemical Classification: Glycopeptide
  • Biological classification: Antibiotics, Antineoplastic

UNSPSC: 51111701

  • E - Medical, Laboratory & Test Equipment & Supplies & Pharmaceuticals
  • 51000000 - Drugs and Pharmaceutical Products
  • 51280000 - Antibacterials
  • 51283200 - Macrolides
     
  • 51110000 - Antineoplastic agents
  • 51111700 - Antineoplastic antibiotics
  • 51111701 - Bleomycin sulphate
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Hygroscopic substance.
Protect from moisture
Other vendors may recommend higher temperatures for storage.
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Shipped at ambient temperature
Shipped in PP / PE bottle.
Available since
Title
Deleted CAS-RN
Value
134171-41-8
Title
Composition for lot BLE001:
Value
Bleomycin A2: 67.81%; Bleomycin B2: 31.62% by HPLC
Fermentek Product Category
Antibiotics
Cancer Related Compounds
Anti Tumor agents
Signal to sort
B

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Price
$1.00