Sinefungin
Molecular Formula
C15H23N7O5
M.W.
381.39
CAS number
58944-73-3
MSDS
Source
Streptomyces sp.
Fermentek product Code
SN
Brand/grade
For research
Appearance
White to yellow powder
Purity by HPLC
≥96% ; refer to CoA for more data
Purity By TLC
≥96% ; refer to CoA for more data
Solubility test
Clear colorless solution at 20mg/ml of water
Names and identifiers

Synonym:

RTECS: HE3140000

UPAC Name: (2S,5S)-2,5-diamino-6-[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]hexanoic acid

 

 
EU number
637-385-5
Description

Natural antibiotic containing adenine, sugar hydroxyl and amino groups; exhibiting Antifungal ,Antimalarial and Antiprotozoal properties.

InChl Key
LMXOHSDXUQEUSF-YECHIGJVSA-N
Canonical SMILES
C1=NC2=C(C(=N1)N)N=CN2C3C(C(C(O3)CC(CCC(C(=O)O)N)N)O)O
Isomeric SMILES
C1=NC2=C(C(=N1)N)N=CN2[C@H]3[C@@H]([C@@H]([C@H](O3)C[C@H](CC[C@@H](C(=O)O)N)N)O)O
Solubility ( literature )

Good water solubility. Soluble in ethanol, methanol, DMF or DMSO (lit.)

Compound Classification

Chemical class:

  • Adenosine analog
  • Nucleoside antibiotic

Biological activity:

  • Antifungal 
  • Antimalarial
  • Antiprotozoal

 

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from moisture
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Applications

Sinefungin derivatives as inhibitors and structure probes of protein lysine methyltransferase SETD2 Antifungal Antimalarials Antiprotozoal

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Not hazardous for transport
Title
toxicity by RTECS oral mouse LD50
Value
1 gram/kg
Signal to sort
S