Nigericin

Nigericin (sodium salt)

Molecular Formula

C40H67O11∙Na

M.W.

746.93

CAS number

28643-80-3 (sodium salt)

MSDS

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Details

Source

Streptomyces hygroscopicus

Fermentek product Code

NIG-001

Brand/grade

For research

Specifications

Appearance

White powder

Purity by HPLC

≥98% ; refer to CoA for more data

Purity By TLC

≥98% ; refer to CoA for more data

Solubility test

Clear colorless solution at 10mg/ml of Dichloromethane

Chemical identification

Names and identifiers

Polyetherin A; Azalomycin M; Helixin C ;

RTECS QT6825000

EU number

608-231-4

Description

Nigericin is a polyether antibiotic which affects ion transport and ATPase activity in mitochondria.

Nigericin is produced by Streptomyces hygroscopicus. Nigericin, an ionophore and antibiotic, is supplied as a sodium salt.

Nigericin is one of the compounds successfully tested as a feed additive, displaying a significant effect on milk production in cattle. In vitro, nigericin has broad biological activity against Gram positive bacteria, fungi, tumor cell lines and some viruses, including HIV.

InChl Key

MOYOTUKECQMGHE-NTQCAYBPSA-M

Canonical SMILES

CC1CCC(OC1C(C)C(=O)[O-])CC2CC(C(C3(O2)C(CC(O3)(C)C4CCC(O4)(C)C5C(CC(O5)C6C(CC(C(O6)(CO)O)C)C)C)C)C)OC.[Na+]

Isomeric SMILES

C[C@H]1CC[C@@H](OC1[C@@H](C)C(=O)[O-])C[C@@H]2C[C@H]([C@H]([C@@]3(O2)[C@@H](C[C@@](O3)(C)C4CC[C@@](O4)(C)C5[C@H](C[C@@H](O5)[C@@H]6[C@H](C[C@H]([C@@](O6)(CO)O)C)C)C)C)C)OC.[Na+]

Further Information

Solubility ( literature )

DMSO, Ethanol, petrol ether. Not soluble in water

Storage, handling

Store in a freezer upon arrival, at -10°C to -25°C

Open carefully – Lyophilized solid under vacuum

Retest time

3 Years

Applications

Disrupts the membrane potential and stimulates ATPase activity in mitochondria.

Disclaimer

For Research use only