Actinomycin D (Dactinomycin)
Molecular Formula
C62H86N12O16
M.W.
1 255.42
CAS number
50-76-0
MSDS
Source
Streptomyces parvulus
Fermentek product Code
ACT-001
Brand/grade
For research
Appearance
Red Shiny to Orange-Red Crystals
Purity by HPLC
≥ 95% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
238°C-255°C
Solubility test
Clear orange solution at 50mg/ml DMSO;
Clear orange solution at 10mg/ml Methanol
Names and identifiers

 

Synonyms:

  • Actinomycin IV 
  • Actinomycin C1
  • Dactinomycin
  • Cosmegen
  • Oncostatin K

Chemical names:

IUPAC: 2-amino-4,6-dimethyl-3-oxo-1-N,9-N-bis[7,11,14-trimethyl-2,5,9,12,15-pentaoxo-3,10-di(propan-2-yl)-8-oxa-1,4,11,14-tetrazabicyclo[14.3.0]nonadecan-6-yl]phenoxazine-1,9-dicarboxamide

RTECS#: AU1575000

EU number
200-063-6
Description

Actinomycin D is an antibiotic, a member of Actinomycins group, derived from Streptomyces parvullus. Actinomycin D binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines.

InChl Key
RJURFGZVJUQBHK-IIXSONLDSA-N
Canonical SMILES
CC1C(C(=O)NC(C(=O)N2CCCC2C(=O)N(CC(=O)N(C(C(=O)O1)C(C)C)C)C)C(C)C)NC(=O)C3=C4C(=C(C=C3)C)OC5=C(C(=O)C(=C(C5=N4)C(=O)NC6C(OC(=O)C(N(C(=O)CN(C(=O)C7CCCN7C(=O)C(NC6=O)C(C)C)C)C)C(C)C)C)N)C
Isomeric SMILES
C[C@@H]1[C@@H](C(=O)N[C@@H](C(=O)N2CCC[C@H]2C(=O)N(CC(=O)N([C@H](C(=O)O1)C(C)C)C)C)C(C)C)NC(=O)C3=C4C(=C(C=C3)C)OC5=C(C(=O)C(=C(C5=N4)C(=O)N[C@H]6[C@H](OC(=O)[C@@H](N(C(=O)CN(C(=O)[C@@H]7CCCN7C(=O)[C@H](NC6=O)C(C)C)C)C)C(C)C)C)N)C
Solubility ( literature )

Actinomycin D is soluble in Dichloromethane or Methanol.

Compound Classification

Oligopeptide antibiotic;

RNA polymerase inhibitor

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from light !
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Very photo-sensitive.
Retest time
3 Years
Applications

Inhibitor of DNA-primed RNA polymerase and DNA polymerase. An apoptosis inducer. Antineoplastic drug.

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Shipped at ambient temperature
Shipped in amber-glass vials
Title
Depreciated CAS Numbers
Value
1402-51-3; 1402-58-0; 1421227-25-9;
Title
Transport information
Value
PG II
Title
sig
Value
114666
Title
TSE
Value
F
Title
CN code
Value
29419000
Fermentek Product Category
Antibiotics
Cytotoxic agents
Research field: Cancer
Signal to sort
A

Quote for

Price
$1.00
Actinomycin_D
Actinomycin_D

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