Protein phosphatases Inhibitors

Microcystin LR

Molecular Formula

C49H74N10O12

M.W.

995.17

CAS number

101043-37-2

MSDS

Download

Details

Source

Microcystis aeruginosa

Fermentek product Code

MLR-001

Brand/grade

For research

Specifications

Appearance

White to green to blue powder

Purity by HPLC

≥98% ; refer to CoA for more data

Solubility test

Clear colorless solution at 1mg/ml Methanol

Chemical identification

Names and identifiers

Synonyms:

Cyanoginosin-LR
Toxin T 17
cyclo[2,3-didehydro-N-methylalanyl-D-alanyl-L-leucyl-(3S)-3-methyl-D-β-aspartyl-L-arginyl-(2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyl-4,6-decadienoyl-D-γ-glutamyl]

Chemical names:

IUPAC:

RTECS GT2810000

EU number

621-323-9

Chemical name

Cyanoginosin LA, 5-L-arginine-

Description

Microcystin-LR (MC-LR) is a toxin produced by fresh water cyanobacteria. It is the most toxic of the microcystins, tumor promoter, potent and selective inhibitor of protein phosphatase 2A (PP2A). Considered to be cell-impermeable with the exception of hepatocytes which take it up via an organic anion pump. Strong hepatotoxin.

InChl Key

ZYZCGGRZINLQBL-DABAWSACSA-N

Canonical SMILES

CC1C(NC(=O)C(NC(=O)C(C(NC(=O)C(NC(=O)C(NC(=O)C(=C)N(C(=O)CCC(NC1=O)C(=O)O)C)C)CC(C)C)C(=O)O)C)CCCN=C(N)N)C=CC(=CC(C)C(CC2=CC=CC=C2)OC)C

Isomeric SMILES

C[C@H]1[C@@H](NC(=O)[C@@H](NC(=O)[C@H]([C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)C(=C)N(C(=O)CC[C@@H](NC1=O)C(=O)O)C)C)CC(C)C)C(=O)O)C)CCCN=C(N)N)/C=C/C(=C/[C@H](C)[C@H](CC2=CC=CC=C2)OC)/C

Further Information

Solubility ( literature )

Soluble in DMSO , methanol , Ethanol.

Storage, handling

Store in a freezer upon arrival, at -10°C to -25°C

Open carefully.

Use the original container to store the product.

Keep the lid tightly closed.

Avoid exposing to strong direct light.

Other vendors may recommend higher temperatures for storage.

Retest time

3 Years