Apoptosis is defined as a process of deliberate cell suicide in a multicellular organism. It is one of the main types of programmed cell death (PCD), and involves an orchestrated series of biochemical events leading to a characteristic cell morphology and death.

The apoptotic process is executed in such a way as to safely dispose of dead cells and fragments.

Apoptosis is a crucial element of the ontogenesis of multicellular organisms. Any aberration in it may lead to neoplastic events, to cancer and to death of the entire organism. Therefore, the Fermentek "Apoptosis related products” are of use in biological and medical research. Some have been the basis for the development of novel drugs.

7-Amino-Actinomycin D (7-AAD)

7-Amino-Actinomycin D (7-AAD)
Molecular Formula
C62H87N13O16
M.W.
1 270.43
CAS number
7240-37-1
MSDS
Source
Semisynthetic Derivate of Actinomycin D
Fermentek product Code
7AD-001
Brand/grade
For research
Appearance
Purple powder
Purity by HPLC
≥97% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
235°C-255°C
Solubility test
Clear purple solution at 20mg/ml DMSO
Names and identifiers

IUPAC name:
2,7-Diamino-N,N'-bis[(6S,9R,10S,13R,18aS)-6,13-diisopropyl-2,5,9-trimethyl-1,4,7,11,14-pentaoxohexadecahydro-1H-pyrrolo[2,1-i][1,4,7,10,13]oxatetraazacyclohexadecin-10-yl]-4,6-dimethyl-3-oxo-3H-phenox azine-1,9-dicarboxamide

RTECS: 

AU1579000

 

EU number
635-285-6
Chemical name
7-Amino-Actinomycin-D
Description

(7-AAD) 7-Amino-Actinomycin-D is produced synthetically from natural Actinomycin D. (7-AAD) 7-Amino-Actinomycin-D binds to single stranded DNA. it is used, as a fluorescent dye, as a reagent capable to distinguish dead and live cells.

InChl Key
YXHLJMWYDTXDHS-UHFFFAOYSA-N
Canonical SMILES
CC1C(C(=O)NC(C(=O)N2CCCC2C(=O)N(CC(=O)N(C(C(=O)O1)C(C)C)C)C)C(C)C)NC(=O)C3=CC(=C(C4=C3N=C5C(=C(C(=O)C(=C5O4)C)N)C(=O)NC6C(OC(=O)C(N(C(=O)CN(C(=O)C7CCCN7C(=O)C(NC6=O)C(C)C)C)C)C(C)C)C)C)N
Solubility ( literature )

Dichloromethane, DMSO, Methanol. Slightly soluble in water

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Hygroscopic substance.
Protect from moisture
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Semi-Synthetic
Ingredient type
Fermentek product
Transport safety: class 6.1 PG II
Available since
Title
Transport information
Value
Pg II
Fermentek Product Category
Antibiotics
Research field: Cancer
Apoptosis related
Anti Tumor agents
DNA replication inhibitors
Research field: Signal Transduction
Signal to sort
A

Quote for

Price
$1.00
7-_Amino-Actinomycin_D
7-_Amino-Actinomycin_D

15-Acetoxyscirpenol

15-Acetoxyscirpenol
Molecular Formula
C17H24O6
M.W.
324.37
CAS number
2623-22-5
MSDS
Source
Semisynthetic
Fermentek product Code
15A-001
Brand/grade
For research
Appearance
White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
160-167°C
Solubility test
Clear colorless solution at 10 mg/ml Methanol;
Clear colorless solution at 10 mg/ml DMSO
Names and identifiers

Synonyms

MAS

15-Acetoxyscirpenol

15-Monoacetoxyscirpenol

15- Deacetylanguidin

4- Deacetylanguidin

IUPAC names:  15-Acetoxyscirpenol

Chemical names: 15-Mono-O-acetylscirpenol;    Deacetylanguidin;    15-Acetoxyscirpenol;

Systematic Name:  Trichothec-9-ene-3-alpha,4-beta,15-triol, 12,13-epoxy-, 15- acetate

RTECS: YD0111000

EU number
636-756-9
Chemical name
15-Acetoxyscirpenol;
Description

MAS (15-Acetoxyscirpenol) is a Trichothecene class mycotoxin. It is closely related to DAS (Diacetoxyscirpenol)

InChl Key
IRXDUBNENLKYTC-DIRMQTSCSA-N
Canonical SMILES
CC1=CC2C(CC1)(C3(C(C(C(C34CO4)O2)O)O)C)COC(=O)C
Isomeric SMILES
CC1=C[C@@H]2[C@](CC1)(C3([C@@H]([C@H]([C@H](C34CO4)O2)O)O)C)COC(=O)C
Solubility ( literature )

Soluble in moderately polar solvents, such as chloroform, diethyl ether, ethyl acetate, and acetone

Compound Classification

Trichothecene

Mycotoxin

Apoptosis inducer

UNSPSC:

123521 Chemicals, including biochemicals.

121615 Chemicals, Additives, Indicators and reagents    

85151701 Healthcare Services;  Food and nutrition services; Food policy planning and aid; Food standards

85131703  Biomedical research services

 

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Use the original container to store the product.
Keep the lid tightly closed.
Other vendors may recommend higher temperatures for storage.
Applications

MAS, as many other anguidine derivates exhibits a strong antimitotic effect,

Disclaimer
Semi-Synthetic
Degree
Grain
Ingredient type
Fermentek product
Title
Transport information
Value
Pg III
Title
Deleted CAS Numbers
Value
174421-33-1; 852222-55-0
Title
CN code
Value
n.a.
Title
CN code
Value
n.a.
Title
C-L inventory
Value
Y
Fermentek Product Category
Food Safety
Food Safety - Sub
Mycotoxins
Food Safety Related
Trichocothecenes
Antibiotics
Cytotoxic agents
Research field: Cancer
Apoptosis related
Signal to sort
A

Quote for

Price
$1.00
15-Acetoxyscirpenol
15-Acetoxyscirpenol animation
15- Acetoxyscirpenol bottle
15-Acetoxyscirpenol
15-Acetoxyscirpenol animation
15- Acetoxyscirpenol bottle
Subscribe to Apoptosis related