- Rd toxin
Deoxynivalenol (DON , Vomitoxin) is a type B trichothecene. It occurs in grains such as wheat, barley, oats, rye, and maize, rice, sorghum. Deoxynivalenol (DON ) is produced by numerous strains of Fusarium and some other fungi. Deoxynivalenol (DON ) poisonings occur both in humans and farm animals. Deoxynivalenol (DON ) is highly toxic, producing a wide range of immunological disturbances and is particularly noted for inducing feed refusal and emesis in pigs, hence the alternative name vomitoxin Deoxynivalenol (DON ) usually co-occurs with other Fusarium toxins, such as Zearalenone, Nivalenol and its derivates, as well as the group of fumonisins.
Deoxynivalenol (DON ) is soluble in common polar organic solvents as acetonitrile, methanol and ethyl acetate, slightly soluble in water.
trichothecene type B mycotoxin
The main toxic effect of Deoxynivalenol (DON ) is inhibition of protein synthesis via binding to the ribosome.In agricultural R&D, DON is widely used to select crops strains with increased resistance against Fusarium.
The Mycotoxin Deoxynivalenol Predisposes for the Development of Clostridium perfringens-Induced Necrotic Enteritis in Broiler ChickensGunther Antonissen , Filip Van Immerseel , Frank Pasmans , Richard Ducatelle, Freddy Haesebrouck, Leen Timbermont, Marc Verlinden, Geert Paul Jules Janssens, Venessa Eeckhaut, Mia Eeckhout, Sarah De Saeger, Sabine Hessenberger, An Martel , Siska Croubels Published: September 30, 2014http://dx.doi.org/10.1371/journal.pone.0108775