Deoxynivalenol (DON)

Molecular Formula:

C15H20O6

CAS number:

51481-10-8

EU number:

610-668-0

Fermentek product code:

DON

Source:

Semisynthetic

Brand/grade:

For research

Specifications

Appearance:

White powder

Purity by HPLC:

≥98% ; refer to CoA for more data

Purity By TLC:

≥98% ; refer to CoA for more data

Melting point:

150°C-155°C

Solubility test:

Clear colorless solution at 10mg/ml Methanol, Ethyl acetate or Ethanol

Chemical identification

Names and identifiers:

Rd toxin
Vomitoxin
Deoxynivalenol
4-Deoxynivalenol
Dehydronivalenol
4-Desoxynivalenol

RTECS YD0167000

Description:

Deoxynivalenol (DON , Vomitoxin) is a type B trichothecene. It occurs in grains such as wheat, barley, oats, rye, and maize, rice, sorghum. Deoxynivalenol (DON ) is produced by numerous strains of Fusarium and some other fungi. Deoxynivalenol (DON ) poisonings occur both in humans and farm animals. Deoxynivalenol (DON ) is highly toxic, producing a wide range of immunological disturbances and is particularly noted for inducing feed refusal and emesis in pigs, hence the alternative name vomitoxin Deoxynivalenol (DON ) usually co-occurs with other Fusarium toxins, such as Zearalenone, Nivalenol and its derivates, as well as the group of fumonisins.

Molecular weight:

296.32

InChl Key:

LINOMUASTDIRTM-QGRHZQQGSA-N

Canonical SMILES:

CC1=CC2C(C(C1=O)O)(C3(CC(C(C34CO4)O2)O)C)CO

Isomeric SMILES:

CC1=C[C@@H]2[C@]([C@@H](C1=O)O)([C@]3(C[C@H]([C@H]([C@@]34CO4)O2)O)C)CO

Further Information

Solubility ( literature ):

Deoxynivalenol (DON ) is soluble in common polar organic solvents as acetonitrile, methanol and ethyl acetate, slightly soluble in water.

Compound Classification:

trichothecene type B mycotoxin

Storage, handling:

Store in a freezer upon arrival, at -10°C to -25°C

Other vendors may recommend higher temperatures for storage.

Applications:

The main toxic effect of Deoxynivalenol (DON ) is inhibition of protein synthesis via binding to the ribosome.In agricultural R&D, DON is widely used to select crops strains with increased resistance against Fusarium.

Disclaimer:

For Research use only

Not for Human or Drug use

Not extracted from humans or animals

Refer to MSDS for further safety and handling instructions

Semi-Synthetic

Composition

Ingredient type:

Fermentek product

Supply related information

Supply related comments:

Customs: Laboratory reagents-38220000

Publications

The Mycotoxin Deoxynivalenol Predisposes for the Development of Clostridium perfringens-Induced Necrotic Enteritis in Broiler ChickensGunther Antonissen , Filip Van Immerseel , Frank Pasmans , Richard Ducatelle, Freddy Haesebrouck, Leen Timbermont, Marc Verlinden, Geert Paul Jules Janssens, Venessa Eeckhaut, Mia Eeckhout, Sarah De Saeger, Sabine Hessenberger, An Martel , Siska Croubels Published: September 30, 2014http://dx.doi.org/10.1371/journal.pone.0108775

Special Info

Available since:

2007

Other Fields

Title:

Deleted CAS Numbers

Value:

50722-37-7 ; 115825-61-1 ; 1394244-12-2