Dihydrocytochalasin B

Molecular Formula

C29H39NO5

M.W.

481.60

CAS number

39156-67-7

MSDS

Download

Details

Source

Semisynthetic

Fermentek product Code

DHB-001

Brand/grade

For research

Specifications

Appearance

White powder

Purity by HPLC

≥95% ; refer to CoA for more data

Purity By TLC

≥98% ; refer to CoA for more data

Melting point

195°C-205°C

Solubility test

Clear colorless solution at 10mg/ml Methanol

Chemical identification

Names and identifiers

Synonyms:

21,22-Dihydrochalasin B
21,22-Dihydrocytochalasin B
21,22-Dihydrophomin

Systematic Name: 7(S),20(R)-Dihydroxy-16(R)-methyl-10-phenyl-24-oxa(14)cytochalasa-6(12),13(E)-diene-1,23-dione

EU number

254-324-4

Description

Dihydrocytochalasin B is chemically derived from Cytochalasin B obtained natural from Drechslera dematoidea fungus.

InChl Key

WIULKAASLBZREV-RXPQEOCGSA-N

Canonical SMILES

CC1CCCC(CCC(=O)OC23C(C=CC1)C(C(=C)C(C2C(NC3=O)CC4=CC=CC=C4)C)O)O

Isomeric SMILES

C[C@@H]1CCC[C@H](CCC(=O)O[C@]23[C@@H](/C=C/C1)[C@@H](C(=C)[C@H]([C@H]2[C@@H](NC3=O)CC4=CC=CC=C4)C)O)O

Further Information

Solubility ( literature )

Acetone, DMSO, 100% Ethanol, Methanol

Compound Classification

Macrolide indol mycotoxin
Cytochalasin
Actin inhibitor

Storage, handling

Deep frozen (-15 oC to - 20 oC)

Retest time

3 Years

Applications

Cytochalasins are used as tools in cytological research, and in in the field of actin polymerisation.

Cytokinesis inhibitor. Inducer of changes in cell morphology and motility. It disrupts actin structure and inhibits ability of serum growth factors to stimulate DNA synthesis in vitro. Does not inhibit sugar uptake. Active calcium transport inhibitor. Active in vivo.

Composition

Ingredient type

Fermentek product

Special Info

Available since

2017