Gliotoxin
Molecular Formula
C13H14N2O4S2
M.W.
326.39
CAS number
67-99-2
MSDS
Source
Gliocladium fimbriatum
Fermentek product Code
GLI-001
Appearance
White to yellow powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
200°C-206°C
Solubility test
Clear colorless solution at 10mg/ml of Methanol
Names and identifiers

Synonyms

  • Aspergillin
  • IUPAC name : (3R,6S,10aR)-6-hydroxy-3-(hydroxymethyl)-2-methyl-2,3,6,10-tetrahydro-5aH-3,10a-epidithiopyrazino[1,2-a]indole-1,4-dione
  • IUPAC name : Gliotoxin

RTECS KB4725000

 

 

 

Description

Gliotoxin is a fungal antibiotic mycotoxin with antiphagycytic and immunomodulatory activities.

Gliotoxin is  an antibiotic that is toxic to higher animals as well as to animal and plant pathogens and that is produced by various fungi (as of the genera Gliocladium, Aspergillus, andPenicillium)

InChl Key
FIVPIPIDMRVLAY-RBJBARPLSA-N
Canonical SMILES
CN1C(=O)C23CC4=CC=CC(C4N2C(=O)C1(SS3)CO)O
Isomeric SMILES
CN1C(=O)[C@]23CC4=CC=C[C@@H]([C@H]4N2C(=O)[C@]1(SS3)CO)O
Solubility ( literature )

DMSO, Methanol, Ethanol, Ethyl acetate, Petrol-ether, Dichloromethane. Water insoluble

Compound Classification

Chemical class:

  • Indole mycotoxin

Bioactivity class:

  • Immunomodulator
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Hygroscopic substance.
Protect from moisture
Protect from light !
Avoid exposing to strong direct light.
Retest time
3 Years
Applications

Gliotoxin blocks the thiol groups in the membranes . Gliotoxin induces apoptotsis in macrophages and thymocytes. Gliotoxin induces Ca2+ release from intact rat liver mitochondria.

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Pg III
Title
CN code
Value
29419000
Signal to sort
G