Antimycin A (complex)
Molecular Formula
C28H40N2O9 (for Antimycin A1)
M.W.
548.62
CAS number
1397-94-0
MSDS
Source
Streptomyces sp.
Fermentek product Code
ANT-001
Brand/grade
For research
Appearance
White to off white powder
Purity by HPLC
≥98% (a mixture of subunits) ; refer to CoA for more data
Solubility test
Clear colorless solution at 50mg/ml of Ethanol (slight heating)
Names and identifiers

Synonyms:

  • Antimycin  A
  • Antimycins A
  • Antipiricullin
  • Fintrol
  • Virosin

Chemical names:

IUPAC:  3-[(3-Formamido-2-hydroxybenzoyl)amino]-8-hexyl-2,6-dimethyl-4,9-dioxo-1,5-dioxonan-7-yl 3-methylbutanoate

RTECS#  CD0350000

EU number
634-284-8
Description

Antimycin A is a complex of related macrocyclic lactones, predominantly A1 to A4, isolated from several species of Streptomyces, first reported in the early 1950s for potent antifungal activity. There are over 20 known analogues in the antimycin A class, mostly involving variation of the fatty acid ester chain length or adjacent alkyl starting unit. Antimycin A binds to cytochrome C reductase at the Qi site, inhibiting the oxidation of ubiquinol to ubiquinone. Antimycin A is widely used as a bioprobe of respiration and other applications with over 5,000 literature citations.

Some of data brought in this page, such as Molecular Weight, relates to Antimycin A1

 

 

InChl Key
UIFFUZWRFRDZJC-RBVQMQRASA-N
Canonical SMILES
CCCCCCC1C(C(OC(=O)C(C(OC1=O)C)NC(=O)C2=C(C(=CC=C2)NC=O)O)C)OC(=O)CC(C)C
Isomeric SMILES
CCCCCCC1[C@H]([C@@H](OC(=O)[C@H]([C@H](OC1=O)C)NC(=O)C2=C(C(=CC=C2)NC=O)O)C)OC(=O)CC(C)C
Solubility ( literature )

(lit) Antimycin A is soluble in DMSO at 2 mg/mL and in 95% ethanol at 50 mg/mL. It is also freely soluble in ether, acetone, and chloroform. It is insoluble in water.

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from moisture
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
CN code
Value
29419000
Title
Deleted CAS Numbers
Value
37330-19-1; 50858-98-5
Title
special link
Value
www.cdc.gov/niosh-rtecs/CD55730.html
Title
toxicity by RTECS
Value
LD50 Oral rat = 28 mg/kg; mouse oral 55 mg/kg;
Title
PG
Value
2
Title
Eco-toxicity
Value
very toxic to bone fish
Title
TSCA
Value
on extremely hazardous subst list
Fermentek Product Category
Antibiotics
Cytotoxic agents
Research field: Cancer
Apoptosis related
Anti Tumor agents
Signal to sort
A

Quote for

Larger quantities available. Please enquire
Price
$100.00
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