Synonyms: Streptogramin A; Mikamycin A; Staphilomycin; Ostreogrycin A; Virginiamycin M1 Pristinamycin IIA;
Virginiamycin M1 is a macrolide antibiotic which interacts with the bacterial 50S ribosome, inhibiting its function in a reversible manner.
Activity of Virginiamycin M1 at the ribosome blocks translation and produces a bacteriostatic effect.
With addition of Virginiamycin S1 the two antibiotics produce a synergistic bacteriocidal effect.
Virginiamycin M1 is soluble in ethanol (3-4%) , methanol (3-4%), DMSO, Dichloromethane, DMF, and sparingly, in water.
Cyclic peptide antibiotic, of Streptogramin group