Nivalenol is a type - B trichothecene mycotoxin produced by various Fusarium species, such as Fusarium cerealis, Fusarium graminearum, Fusarium nivale. Besides the natural toxin produced directly by molds, Nivalenol may be also formed by higher plants and by mammals, as a product of biodegradation of other, related thrichothecenes.
Dichloromethane, DMSO, Methanol. Slightly soluble in water
Nivalenol (0.01 mg/ml) induces apoptosis in HL60 cells (Ueno et al., 1995). Nivalenol was shown to inhibit protein synthesis in rabbit reticulocytes in vitro. Nivalenol inhibited the synthesis of nucleic acids in vitro.