Mycotoxins are defined as naturally occurring substances produced by filamentous fungi (moulds) that arouse toxic response when introduced in low amounts to animals through a natural pathway. These fungi are referred to as “toxigenic” fungi. They grow naturally as a form of contaminants on some food crops, majorly cereals, nuts and fruit. Conventionally, toxigenic fungi which contaminate crops have been classified into two groups: “field” and “storage” fungi. Field fungi (such as Cladosporium, Fusarium and Alternaria spp.) get to plants during the developmental stage of the plant; while storage fungi (e.g., Aspergillus and Penicillium spp.) proliferate during the storage period.

Mycotoxins, which are low weight secondary metabolites, produce harmful substances called Mycotoxicoses in animals which invariably impact public health. The toxicity effects of Mycotoxins could be acute or chronic, or both. The most toxic of these, is Aflatoxins. Aflatoxins B1, B2, G1 and G2 are a critical concern. A low-level exposure to Aflatoxin for a long term has been associated with different liver diseases such as cancer, jaundice, cirrhosis and hepatis. Also, they are genotoxic (DNA-damaging) carcinogenic and immunosuppressants. Ochratoxin A is another type of mycotoxin that is teratogenic (reproductive), immunosuppressant, and had been proved to have connection with kidney diseases. Other toxigenic fungi are associated with protein synthesis inhibition, genotoxic, and immune dysfunction.

Fermentek is a global leader in the production of high-standard reference material for Mycotoxins for food safety analysis and research. The company offers more than 60 types of Mycotoxins manufactured from various different microorganisms, divided into nine known Mycotoxin families. These products are formulated into a powdered form or standard solutions with high purity characterized by their melting points, TLC & HPLC. 

mycotoxins

Aflatoxin B2

Molecular Formula
C17H14O6
M.W.
314.29
CAS number
7220-81-7
MSDS
Source
Aspergillus flavus
Fermentek product Code
AFB-002
Brand/grade
For research
Appearance
White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
290°C-316°C
Solubility test
Clear colorless solution at 5mg/ml Dichloromethane
Names and identifiers

Dihydroaflatoxin B

HSDB 3454

RTECS: GY1720000

 

 

EU number
230-618-8
Description

8,9-dihidro derivate of aflatoxin B1.

A potent hepatotoxic and hepatocarcinogenic mycotoxin

InChl Key
WWSYXEZEXMQWHT-WNWIJWBNSA-N
Canonical SMILES
COC1=C2C3=C(C(=O)CC3)C(=O)OC2=C4C5CCOC5OC4=C1
Isomeric SMILES
COC1=C2C3=C(C(=O)CC3)C(=O)OC2=C4[C@@H]5CCO[C@@H]5OC4=C1
Solubility ( literature )

DMSO or MeOH

Compound Classification

Furano-furano-Benzopyran-mycotoxin

Aflatoxin

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
PG I
Signal to sort
A

Aflatoxin B1

Molecular Formula
C17H12O6
M.W.
312.27
CAS number
1162-65-8
MSDS
Source
Aspergillus flavus
Fermentek product Code
AFB-001
Brand/grade
For research
Appearance
White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
260°C-269°C
Solubility test
Clear colorless solution at 10 mg/ml of Dichloromethane
Names and identifiers

2,3,6aα,9aα-tetrahydro-4-methoxycyclopenta[c]furo[2',3':4,5]furo[2,3-h]chromene-1,11-dione

HSDB 3453

EU number
214-603-3
Description

Aflatoxin B1 is a potent hepatotoxic and hepatocarcinogenic mycotoxin. It is also mutagenic, teratogenic, and causes immunosuppression in animals.

InChl Key
OQIQSTLJSLGHID-WNWIJWBNSA-N
Canonical SMILES
COC1=C2C3=C(C(=O)CC3)C(=O)OC2=C4C5C=COC5OC4=C1
Isomeric SMILES
COC1=C2C3=C(C(=O)CC3)C(=O)OC2=C4[C@@H]5C=CO[C@@H]5OC4=C1
Solubility ( literature )

May be dissolved in DCM, DMSO or Methanol

Compound Classification

Furano-furano-Benzopyran mycotoxin Aflatoxin

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Use the original container to store the product.
Keep the lid tightly closed.
Open carefully – Lyophilized solid under vacuum
Retest time
3 Years
Ingredient type
Fermentek product
Shipped in amber-glass vials
Transport safety: class 6.1 PG I
Available since
Title
Transport information
Value
PG I
Title
HS FER recommendation
Value
Laboratory reagents or reference material-38220000
Title
HS--EU
Value
Heterocyclic compounds wi/ oxygen hetero-atom(s) only; lactones; other
Signal to sort
A

Aflatoxicol

Aflatoxicol
Molecular Formula
C17H14O6
M.W.
314.30
CAS number
29611-03-8
MSDS
Source
Semisynthetic
Fermentek product Code
AFX-001
Brand/grade
For research
Appearance
White powder
Purity by HPLC
≥98% ; refer to CoA for lot specific data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
198°C-200°C
Solubility test
Clear colorless solution at 1 mg/ml Methanol
Names and identifiers

 

Synonyms:

  • Aflatoxicol
  • Aflatoxin R0 natural isomer
  • [1S-(1α,6aβ,9aβ)]-2,3,6a,9a-tetrahydro-1-hydroxy-4-methoxycyclopenta[c]furo[3',2':4,5]furo[2,3-h][1]benzopyran-11(1H)-one

RTECS:  GY1934000

EU number
249-727-7
Chemical name
(1R,6aS,9aS)-1-hydroxy-4-(methyloxy)-2,3,6a,9a-tetrahydrocyclopenta[c]furo[3',2':4,5]furo[2,3-h]chromen-11(1H)-one
Description

Aflatoxicol, (Aflatoxin R0), is a rare natural toxin,  similar but less toxic to Aflatoxin B1

InChl Key
WYIWLDSPNDMZIT-IRWWLHRVSA-N
Canonical SMILES
COC1=C2C3=C(C(CC3)O)C(=O)OC2=C4C5C=COC5OC4=C1
Isomeric SMILES
COC1=C2C3=C([C@H](CC3)O)C(=O)OC2=C4[C@@H]5C=CO[C@@H]5OC4=C1
Solubility ( literature )

May be dissolved in DCM, DMSO or Methanol.(Lit)

Compound Classification

 

  • Furano-furano-Benzopyran mycotoxin
  • Aflatoxin

 

 

 

 

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Standard reference solution available - inquire
Retest time
3 Years
Disclaimer
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Semi-Synthetic
Ingredient type
Fermentek product
Amber-glass vial.
Available since
Title
Transport information
Value
PG I
Title
Deleted CAS Numbers
Value
30811-08-6; 40009-64-1
Signal to sort
A

15-Acetoxyscirpenol

15-Acetoxyscirpenol
Molecular Formula
C17H24O6
M.W.
324.37
CAS number
2623-22-5
MSDS
Source
Semisynthetic
Fermentek product Code
15A-001
Brand/grade
For research
Appearance
White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
160-167°C
Solubility test
Clear colorless solution at 10 mg/ml Methanol;
Clear colorless solution at 10 mg/ml DMSO
Names and identifiers

Synonyms

MAS

15-Acetoxyscirpenol

15-Monoacetoxyscirpenol

15- Deacetylanguidin

4- Deacetylanguidin

IUPAC names:  15-Acetoxyscirpenol

Chemical names: 15-Mono-O-acetylscirpenol;    Deacetylanguidin;    15-Acetoxyscirpenol;

Systematic Name:  Trichothec-9-ene-3-alpha,4-beta,15-triol, 12,13-epoxy-, 15- acetate

RTECS: YD0111000

EU number
636-756-9
Chemical name
15-Acetoxyscirpenol;
Description

MAS (15-Acetoxyscirpenol) is a Trichothecene class mycotoxin. It is closely related to DAS (Diacetoxyscirpenol)

InChl Key
IRXDUBNENLKYTC-DIRMQTSCSA-N
Canonical SMILES
CC1=CC2C(CC1)(C3(C(C(C(C34CO4)O2)O)O)C)COC(=O)C
Isomeric SMILES
CC1=C[C@@H]2[C@](CC1)(C3([C@@H]([C@H]([C@H](C34CO4)O2)O)O)C)COC(=O)C
Solubility ( literature )

Soluble in moderately polar solvents, such as chloroform, diethyl ether, ethyl acetate, and acetone

Compound Classification

Trichothecene

Mycotoxin

Apoptosis inducer

UNSPSC:

123521 Chemicals, including biochemicals.

121615 Chemicals, Additives, Indicators and reagents    

85151701 Healthcare Services;  Food and nutrition services; Food policy planning and aid; Food standards

85131703  Biomedical research services

 

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Use the original container to store the product.
Keep the lid tightly closed.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Applications

MAS, as many other anguidine derivates exhibits a strong antimitotic effect,

Disclaimer
Semi-Synthetic
Degree
Grain
Ingredient type
Fermentek product
Title
Transport information
Value
Pg III
Title
Deleted CAS Numbers
Value
174421-33-1; 852222-55-0
Title
CN code
Value
n.a.
Title
CN code
Value
n.a.
Title
C-L inventory
Value
Y
Signal to sort
A