Satratoxin H

Molecular Formula:

C29H36O9

CAS number:

53126-64-0

EU number:

Not on ECHA as on 11-2023

Fermentek product code:

SAH

Source:

Stachybotrys chartarum

Brand/grade:

For research

Specifications

Appearance:

White to Off-White powder

Purity by HPLC:

≥98% ; refer to CoA for more information

Purity By TLC:

Single spot on TLC plates, by multiple methods.

Solubility test:

Clear colorless solution at 10mg/ml of Chloroform Clear colorless solution at 10mg/ml of DMSO

Chemical identification

Names and identifiers:

Synonyms:

Spiro(5,9,16,18-dimethano-1H,3H,23H-(1,6,12)trioxacyclooctadecino(3,4-d)(1)benzopyran-17(18H),2'-oxirane)-3,14(9H)-dione, 6,7,16,16a,19a,22-hexahydro-25-hydroxy-9-((1S)-1-hydroxyethyl)-16a,21-dimethyl-, (2'R,4E,9R,10E,12Z,16R,16aS,18R,19aR,23aR,25R)-

Chemical names:

IUPAC:

RTECS# VQ5952000

Depreciated CAS numbers: 54385-59-0, 60538-73-0

Description:

Type D highly toxic trichothecene mycotoxin, associated with "sick homes syndrome".

Molecular weight:

528.59

InChl Key:

MUACSCLQRGEGOE-RXLTUBJDSA-N

Canonical SMILES:

CC1=CC2C3(CC1)COC(=O)C=C4CCOC(C4O)(C=CC=CC(=O)OC5C3(C6(CO6)C(C5)O2)C)C(C)O

Isomeric SMILES:

CC1=C[C@@H]2[C@@]3(CC1)COC(=O)C=C4CCO[C@](C4O)(/C=C/C=C/C(=O)O[C@H]5[C@]3([C@]6(CO6)[C@@H](C5)O2)C)[C@H](C)O

Further Information

Solubility ( literature ):

Insoluble in water,soluble in lower alcohols and polar solvents including

methanol,
ethanol,
isopropanol
propylene glycol,
acetone,
ethyl acetate
chloroform,
dimethyl sulfoxide

Storage, handling:

Store in a freezer upon arrival, at -10°C to -25°C

Hygroscopic substance.

Open carefully.

Use the original container to store the product.

Keep the lid tightly closed.

Avoid exposing to strong direct light.

Other vendors may recommend higher temperatures for storage.

Protect from moisture!

Disclaimer:

For Research use only

Not for Human or Drug use

Not extracted from humans or animals

Refer to MSDS for further safety and handling instructions

Composition

Ingredient type:

Fermentek product

Supply related information

Supply related comments:

Customs: Other Antibiotics-29419000

Customs: Laboratory reagents-38220000

EU customs: 29419000 other antibiotics

Transport safety: Not Dangerous Goods; Not Regulated

Publications

Nusuetrong, P., Pengsuparp, T., Meksuriyen, D., Tanitsu, M., Kikuchi, H., Mizugaki, M., Shimazu, K., Oshima, Y., Nakahata, N., Yoshida, M.:
Satratoxin H generates reactive oxygen species and lipid peroxides in PC12 cells.
Biol Pharm Bull 31, 1115–1120 (2008).

Nusuetrong, P., Saito, M., Kikuchi, H., Oshima, Y., Moriya, T., Nakahata, N.:
Apoptotic effects of satratoxin H is mediated through DNA double-stranded break in PC12 cells.
J Toxicol Sci 37, 803–812 (2012)