Nigericin (sodium salt)
Molecular Formula
C40H67O11∙Na
M.W.
746.93
CAS number
28643-80-3 (sodium salt)
MSDS
Details
Source
Streptomyces hygroscopicus
Fermentek product Code
NIG-001
Brand/grade
For research
Specifications
Appearance
White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless solution at 10mg/ml of Dichloromethane
Chemical identification
Names and identifiers
Polyetherin A; Azalomycin M; Helixin C ;
RTECS QT6825000
EU number
608-231-4
Description
Nigericin is a polyether antibiotic which affects ion transport and ATPase activity in mitochondria.
Nigericin is produced by Streptomyces hygroscopicus. Nigericin, an ionophore and antibiotic, is supplied as a sodium salt.
Nigericin is one of the compounds successfully tested as a feed additive, displaying a significant effect on milk production in cattle. In vitro, nigericin has broad biological activity against Gram positive bacteria, fungi, tumor cell lines and some viruses, including HIV.
InChl Key
MOYOTUKECQMGHE-NTQCAYBPSA-M
Canonical SMILES
CC1CCC(OC1C(C)C(=O)[O-])CC2CC(C(C3(O2)C(CC(O3)(C)C4CCC(O4)(C)C5C(CC(O5)C6C(CC(C(O6)(CO)O)C)C)C)C)C)OC.[Na+]
Isomeric SMILES
C[C@H]1CC[C@@H](OC1[C@@H](C)C(=O)[O-])C[C@@H]2C[C@H]([C@H]([C@@]3(O2)[C@@H](C[C@@](O3)(C)C4CC[C@@](O4)(C)C5[C@H](C[C@@H](O5)[C@@H]6[C@H](C[C@H]([C@@](O6)(CO)O)C)C)C)C)C)OC.[Na+]
Further Information
Solubility ( literature )
DMSO, Ethanol, petrol ether. Not soluble in water
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Open carefully – Lyophilized solid under vacuum
Retest time
3 Years
Applications
Disrupts the membrane potential and stimulates ATPase activity in mitochondria.
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Composition
Ingredient type
Fermentek product
Supply related information
Shipped at ambient temperature
Shipped in amber-glass vials
Special Info
Available since
Other Fields
Title
More about
Value
Nigericin f.a.; cas 28380-24-7 rtecs QT6825000, mouse oral ld50=190 mg/kg
Fermentek Product Category
Signal to sort
N
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