Puromycin dihydrochloride

Molecular Formula

C22H29N7O5·(HCl)2

M.W.

544.43

CAS number

58-58-2

MSDS

Download

Details

Source

Streptomyces alboniger

Fermentek product Code

PUR-001

Brand/grade

For research

Specifications

Appearance

White to Off-White powder

Purity by HPLC

≥98% ; refer to CoA for more data

Purity By TLC

≥98% ; refer to CoA for more data

Melting point

≥160°C (dec.)

Solubility test

Clear, slightly brown solution at 50mg/ml of water

Chemical identification

Names and identifiers

Synonyms:

Stylomycin
Achromycin

IUAPC name: 3'-deoxy-N,N-dimethyl-3'-[(O-methyl-L-tyrosyl)amino]adenosine dihydrochloride

RTECS AU7355000

EU number

200-388-3

Chemical name

Adenosine, 3'-[[(2S)-2-amino-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3'-deoxy-N,N-dimethyl-, hydrochloride (1:2)

Description

Puromycin is a protein synthesis inhibitor. It causes premature chain termination.

InChl Key

RYSMHWILUNYBFW-UHFFFAOYSA-N

Canonical SMILES

CN(C)C1=NC=NC2=C1N=CN2C3C(C(C(O3)CO)N)O

Isomeric SMILES

CN(C)C1=NC=NC2=C1N=CN2[C@H]3[C@@H]([C@@H]([C@H](O3)CO)NC(=O)[C@H](CC4=CC=C(C=C4)OC)N)O.Cl.Cl

Further Information

Compound Classification

Nucleoside antibiotic.
Protein synthesis inhibitor

Storage, handling

Store in a freezer upon arrival, at -10°C to -25°C

Protect from moisture

Protect from light !

Other vendors may recommend higher temperatures for storage.

Retest time

3 Years

Applications

Puromycin is an antibiotic used for selecting mammalian cell lines, which have been transformed by vectors that express puromycin-N-acetyl-transferase. Puromycin is also a Antineoplastic agent. Puromycin possesses antoprotozoal activities (against Trypanozoma)

Disclaimer

For Research use only

Not for Human or Drug use

Not extracted from humans or animals

Refer to MSDS for further safety and handling instructions

Puromycin is available also in "Animal-Free version", please inquire.

Composition

Ingredient type

Fermentek product

Special Info

Available since

2004