Thiolutin
Molecular Formula
C8H8N2O2S2
M.W.
228.29
CAS number
87-11-6
Source
Streptomyces luteosporeus
Fermentek product Code
THL-001
Brand/grade
For research
Appearance
Yellow powder
Purity by HPLC
≥97% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear yellow solution at 1mg/ml DMSO
Names and identifiers

RTECS JP1355000

Farcinicin,

Propiopyvothine,

Acetopyrrothine

Description

Thiolutin is a sulfur-containing antibiotic, which is a potent inhibitor of bacterial and yeast RNA polymerases. It was found to inhibit in vitro RNA synthesis directed by all three yeast RNA polymerases (I, II, and III). Thiolutin is also an inhibitor of mannan and glucan formation in Saccharomyces cerevisiae and used for the analysis of mRNA stability. Studies have shown that thiolutin inhibits adhesion of human umbilical vein endothelial cells (HUVECs) to vitronectin and thus suppresses tumor cell-induced angiogenesis in vivo.

InChl Key
MHMRAFONCSQAIA-UHFFFAOYSA-N
Canonical SMILES
CC(=O)NC1=C2C(=CSS2)N(C1=O)C
Solubility ( literature )

Thiolutin is soluble in Dichloromethane or Methanol, DMSO (0.5%)Water solubility: 0.2 gram /Liter

Compound Classification

dithiolopyrrolonePyrrolidinone antibioticRNA polymeraseinhibitorangiogenesis inhibitor

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Protect from moisture! Hygroscopic substance.
Applications

Inhibitor of DNA-primed RNA polimerase and DNA polimerase. Apoptosis inducer. Antineoplastic drug

Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Pg II
Fermentek Product Category
Signal to sort
T