Antibiotic from Fusarium equiseti; derivative of N-methyl-2,4-pyrollidone
Equisetin is reported to be soluble in DMF or DMSO, moderately soluble in methanol or ethanol and poorly soluble in water.
Equisetin solubility as reported in an original patent,
- in acetone of 660 mg./ml.,
- in ethanol of 330 mg./ml.,
- in methanol of 220 mg./ml.,
- in hexane of 0.8 mg./ml.,
- in water of 0.3 mg./ml.
Elemental analysis: C, 70.95; H, 8.39; N, 3.14;
Tetramic acid class antibiotic.
Classification by Bioactivity:
Equisetin inhibits some ATPases, and affects several energy related mitochondrial enzymes.Equisetin was also shown to inhibit (in-vitro) HIV-1 integrase.