Dihydrocytochalasin B
Molecular Formula
C29H39NO5
M.W.
481.60
CAS number
39156-67-7
MSDS
Details
Source
Semisynthetic
Fermentek product Code
DHB-001
Brand/grade
For research
Specifications
Appearance
White powder
Purity by HPLC
≥95% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
195°C-205°C
Solubility test
Clear colorless solution at 10mg/ml Methanol
Chemical identification
Names and identifiers
Synonyms:
- 21,22-Dihydrochalasin B
- 21,22-Dihydrocytochalasin B
- 21,22-Dihydrophomin
Systematic Name: 7(S),20(R)-Dihydroxy-16(R)-methyl-10-phenyl-24-oxa(14)cytochalasa-6(12),13(E)-diene-1,23-dione
EU number
254-324-4
Description
Dihydrocytochalasin B is chemically derived from Cytochalasin B obtained natural from Drechslera dematoidea fungus.
InChl Key
WIULKAASLBZREV-RXPQEOCGSA-N
Canonical SMILES
CC1CCCC(CCC(=O)OC23C(C=CC1)C(C(=C)C(C2C(NC3=O)CC4=CC=CC=C4)C)O)O
Isomeric SMILES
C[C@@H]1CCC[C@H](CCC(=O)O[C@]23[C@@H](/C=C/C1)[C@@H](C(=C)[C@H]([C@H]2[C@@H](NC3=O)CC4=CC=CC=C4)C)O)O
Further Information
Solubility ( literature )
Acetone, DMSO, 100% Ethanol, Methanol
Compound Classification
- Macrolide indol mycotoxin
- Cytochalasin
- Actin inhibitor
Storage, handling
Deep frozen (-15 oC to - 20 oC)
Applications
Cytochalasins are used as tools in cytological research, and in in the field of actin polymerisation.
Cytokinesis inhibitor. Inducer of changes in cell morphology and motility. It disrupts actin structure and inhibits ability of serum growth factors to stimulate DNA synthesis in vitro. Does not inhibit sugar uptake. Active calcium transport inhibitor. Active in vivo.
Composition
Ingredient type
Fermentek product
Special Info
Available since
Other Fields
Title
sig
Value
250225
Title
TSE
Value
S
Title
Transport information
Value
Pg III
Title
EU
Value
254-324-4; On REACH List of Pre-Registered Substances, March 2009 Registration Date: 31-MAY-2013
Title
CAS deleted numbers
Value
74409-92-0 ;
Title
Other sites info
Value
Most sites give wrong RTECS number RO0205000 belonging to Phomin
Fermentek Product Category
Signal to sort
D
