Details
Specifications
Chemical identification
Synonyms:
- Bla-S
- Blasticidin S, monohydrochloride (8CI)
IUPAC Name:
(2S,3S, 6R)-3-[[(3R)-3-amino-5-[carbamimidoyl(methyl)amino]pentanoyl]amino]-6-(4-amino-2-oxopyrimidin-1-yl)-3,6-dihydro-2H-pyran-2-carboxylicacid; hydrochloride
RTECS: EC4900000
Blasticidin S Hydrochloride belongs to a group of cytosine amino nucleoside antibiotics.
The compound Blasticidin S has a wide spectrum of antimicrobial activity and acts on prokaryotic and eukaryotic organisms by inhibiting protein synthesis.
Further Information
Soluble in water, Acetic acid. Slightly soluble in acidified methanol.
Cytosine amino nucleoside type antibiotic
Blasticidin-S is a commonly used tool in genetic engineering. Blasticidin-S inhibits protein synthesis in both prokaryotic and eukaryotic cells. It is common method to include a gene for Blasticidin S resistance into the plasmid being inserted into the target cells, and then to apply Blasticidin S to the culture to select these cells that have acquired that immunity. The Blasticidin S gene resistance gene (BSR), found in Bacillus cereus K55-S1, has been used in multiple studies for its use as a selective compound. Another antibiotic that belongs to the family of nucleosides is Puromycin.
