Aureothricin

Molecular Formula

C9H10N2O2S2

M.W.

242.30

CAS number

574-95-8

Details

Source

Streptomyces luteosporeus

Fermentek product Code

AUR-001

Brand/grade

For research

Specifications

Appearance

Yellow crystalline powder

Purity by HPLC

≥98% ; refer to CoA for more data

Purity By TLC

≥98% ; refer to CoA for more data

Melting point

280°C-285°C

Solubility test

Clear yellow solution at 1 mg/ml DMSO or DMF

Chemical identification

Names and identifiers

IUPACK name:

N-(4-methyl-5-oxodithiolo[4,3-b]pyrrol-6-yl)propanamide;

N-(4,5-dihydro-4-methyl-5-oxo-1,2-dithiolo[4,3-b]pyrrol-6-yl)-propanamide;

Chemical names:

Aureothricin; Propionopyrrothine; Farcinicin

Chemical name

N-(4,5-Dihydro-4-methyl-5-oxo-1,2-dithiolopyrrol-6-yl)-propanamide

Description

Aureothricin is a small-molecule antibiotic containing sulfur, with many valuable antibacterial, antifungal and anti-angiogenetic properties. Chemically it is an analog of Thioluthin.

InChl Key

UGZYFXMSMFMTSM-UHFFFAOYSA-N

Canonical SMILES

CCC(=O)NC1=C2C(=CSS2)N(C1=O)C

Further Information

Solubility ( literature )

Aureothricin is soluble in Dichloromethane, DMSO and DMF. Moderately soluble in low alcohols such as Methanol and Ethanol. It is more hydrophobic than thiolutin; practically insoluble in water.

Compound Classification

Dithiolopyrrolone
Pyrrolidinone antibiotic

Storage, handling

Store in a freezer upon arrival, at -10°C to -25°C

Protect from moisture

Avoid exposing to strong direct light.

Applications

RNA polymerase inhibitor Angiogenesis inhibitor Inhibitor of tumour-cell induced angiogenesis in vivo. Antineoplastic properties. Antibacterial and antifungal properties.

Disclaimer

For Research use only

Not for Human or Drug use

Not extracted from humans or animals

Refer to MSDS for further safety and handling instructions

Composition

Ingredient type

Fermentek product

Special Info

Available since

2016