Nonactin complex (mixture of Nonactin, Monactin, Dinactin and Trinactin)
Molecular Formula
C40H64O12
M.W.
736.93
CAS number
6833-84-7 (for Nonactin)
MSDS
Source
Streptomyces griseus
Fermentek product Code
NON-001
Brand/grade
For research
Appearance
White to off white powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless solution at 10mg/ml DMSO or Dichloromethane
Names and identifiers

 

  • Ammonium Ionophore
  • Werramycin A
  • Polynactin

RTECS: RH1685000

EU number
229-911-3
Description

Nonactin (Complex) from Streptomyces Griseus: is a mixture of sum homolog macrotetrolide antibiotics: Nonactin, Monactin or any other homologs such as Dinactin, Trinactin, Tetranactin. It is being manucatured in Fermentek since 2004.

Since 2025, Fermentek manufactures also pure Nonactin and Monactin

 

InChl Key
RMIXHJPMNBXMBU-QIIXEHPYSA-N
Canonical SMILES
CC1CC2CCC(O2)C(C(=O)OC(CC3CCC(O3)C(C(=O)OC(CC4CCC(O4)C(C(=O)OC(CC5CCC(O5)C(C(=O)O1)C)C)C)C)C)C)C
Isomeric SMILES
C[C@@H]1C[C@H]2CC[C@H](O2)[C@@H](C(=O)O[C@H](C[C@@H]3CC[C@@H](O3)[C@H](C(=O)O[C@@H](C[C@H]4CC[C@H](O4)[C@@H](C(=O)O[C@H](C[C@@H]5CC[C@@H](O5)[C@H](C(=O)O1)C)C)C)C)C)C)C
Solubility ( literature )

soluble in Methanol, Dichloromethane, Ethyl Acetate, DMSO.

Insoluble in water

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Open carefully
Applications

Nonactin has an inhibitory effects on the P170 glycoprotein-mediated efflux of chemotherapeutic agents in multiple-drug-resistant cancer cells.

Nonactin, a natural mixture of macrotetrolides, was used in agriculture under the name trade Polynactin. Nonactin has been reported to specifically inhibit the processing of cytoplasmic precursor proteins destined for the mitochondria.

Nonactin is used in urea and ammonium specific electrodes.

Disclaimer
Not for Human or Drug use
Not extracted from humans or animals
Refer to SDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Not hazardous for transport
Fermentek Product Category
Antibiotics
Ionophores
Signal to sort
N

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Price
$1.00
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ADDITIONAL PRODUCTS

Nonactin
CAS number: CAS #: 6833-84-7
Product code: NON-002
Source: Streptomyces griseus
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Nonactin
CAS number: CAS #: 6833-84-7
Product code: NON-002
Source: Streptomyces griseus
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Monactin
CAS number: CAS #: 7182-54-9
Product code: MON-002
Source: Streptomyces griseus
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Monactin
CAS number: CAS #: 7182-54-9
Product code: MON-002
Source: Streptomyces griseus
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Valinomycin
CAS number: CAS #: 2001-95-8
Product code: VAL-001
Source: Streptomyces fulvissimus
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Valinomycin
CAS number: CAS #: 2001-95-8
Product code: VAL-001
Source: Streptomyces fulvissimus
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