Nonactin

Molecular Formula

C40H64O12

M.W.

736.93

CAS number

6833-84-7

Details

Source

Streptomyces griseus var griseus

Fermentek product Code

NON-001

Brand/grade

For research

Specifications

Appearance

White needle-like crystals.

Purity by HPLC

≥98% ; refer to CoA for more data

Melting point

145°C-146°C

Crystallinity

Crystalline

Solubility test

Clear colorless solution at 10mg/ml Dichloromethane or 10mg/ml DMSO

Chemical identification

Names and identifiers

Ammonium Ionophore.
Werramycin-A.
Polynactin

RTECS: RH1685000

EU number

229-911-3

Description

Nonactin from Streptomyces Griseus: a mixture of the two homolog macrotetrolide antibiotics: Nonactin, Monactin. Nonactin is not less than 80%, ballanced by Monactin only. The mixture does not contain any other natcins, such as Dinactin, Trinactin, Tetranactin. Nonactin batches released since May 2010 are better than 95% Nonactin by NMR; detailed information is available on request.

InChl Key

RMIXHJPMNBXMBU-QIIXEHPYSA-N

Canonical SMILES

CC1CC2CCC(O2)C(C(=O)OC(CC3CCC(O3)C(C(=O)OC(CC4CCC(O4)C(C(=O)OC(CC5CCC(O5)C(C(=O)O1)C)C)C)C)C)C)C

Isomeric SMILES

C[C@@H]1C[C@H]2CC[C@H](O2)[C@@H](C(=O)O[C@H](C[C@@H]3CC[C@@H](O3)[C@H](C(=O)O[C@@H](C[C@H]4CC[C@H](O4)[C@@H](C(=O)O[C@H](C[C@@H]5CC[C@@H](O5)[C@H](C(=O)O1)C)C)C)C)C)C)C

Further Information

Solubility ( literature )

soluble in Methanol, Dichloromethane, Ethyl Acetate, DMSO.

Insoluble in water

Storage, handling

Refrigerate upon arrival, at +2°C to +8°C

Hygroscopic substance.

Protect from moisture

Open carefully.

Other vendors may recommend higher temperatures for storage.

Retest time

3 Years

Applications

Nonactin has an inhibitory effects on the P170 glycoprotein-mediated efflux of chemotherapeutic agents in multiple-drug-resistant cancer cells.

Nonactin, a natural mixture of macrotetrolides, was used in agriculture under the name trade POLYNACTIN. Nonactin has been reported to specifically inhibit the processing of cytoplasmic precursor proteins destined for the mitochondria.

Nonactin is used in urea and ammonium specific electrodes.

Disclaimer

Not for Human or Drug use

Not extracted from humans or animals

Refer to MSDS for further safety and handling instructions

Composition

Ingredient type

Fermentek product

Special Info

Available since

2004