Mithramycin A

Molecular Formula

C52H76O24

M.W.

1 085.00

CAS number

18378-89-7

MSDS

Download

Details

Source

Streptomyces argillaceus

Fermentek product Code

MTA-001

Brand/grade

For research

Specifications

Appearance

Yellow powder

Purity by HPLC

≥98% ; refer to CoA for more data

Purity By TLC

≥98% ; refer to CoA for more data

Melting point

175°C-185°C

Solubility test

Clear yellowish solution at 100mg/ml DMSO

Chemical identification

Names and identifiers

Synonyms:

Mithramycin
Plicamycin
Aureolic acid

RTECS: PZ2800000

EU number

634-048-4

Description

Oligosaccharide antibiotic, a RNA synthesis inhibitor.

InChl Key

CFCUWKMKBJTWLW-BKHRDMLASA-N

Canonical SMILES

CC1C(C(CC(O1)OC2CC(OC(C2O)C)OC3=CC4=CC5=C(C(=O)C(C(C5)C(C(=O)C(C(C)O)O)OC)OC6CC(C(C(O6)C)O)OC7CC(C(C(O7)C)O)OC8CC(C(C(O8)C)O)(C)O)C(=C4C(=C3C)O)O)O)O

Isomeric SMILES

C[C@@H]1[C@H]([C@@H](C[C@@H](O1)O[C@@H]2C[C@@H](O[C@@H]([C@H]2O)C)OC3=CC4=CC5=C(C(=O)[C@H]([C@@H](C5)[C@@H](C(=O)[C@H]([C@@H](C)O)O)OC)O[C@H]6C[C@H]([C@@H]([C@H](O6)C)O)O[C@H]7C[C@H]([C@H]([C@H](O7)C)O)O[C@H]8C[C@]([C@@H]([C@H](O8)C)O)(C)O)C(=C4C(=C3C)O)O)O)O

Further Information

Solubility ( literature )

DMSO, Methanol, Ethanol

Compound Classification

Anthracycline Pentaglycosidic antibiotic.

RNA synthesis inhibitor

Storage, handling

Store in a freezer upon arrival, at -10°C to -25°C

Protect from moisture

Avoid exposing to strong direct light.

Store under argon.

Other vendors may recommend higher temperatures for storage.

Retest time

3 Years

Applications

DNA binding fluorescent dye. Until 2000 it was used to reduce high levels of plasma calcium. Used as an antineoplastic agent in the treatment of testicular cancer, Paget's disease of bone, and, rarely, the management of hypercalcemia.

Disclaimer

For Research use only

Not for Human or Drug use

Not extracted from humans or animals

Refer to MSDS for further safety and handling instructions

Composition

Ingredient type

Fermentek product

Special Info

Available since

2004