Gliotoxin

Molecular Formula

C13H14N2O4S2

M.W.

326.39

CAS number

67-99-2

MSDS

Download

Details

Source

Gliocladium fimbriatum

Fermentek product Code

GLI-001

Specifications

Appearance

White to yellow powder

Purity by HPLC

≥98% ; refer to CoA for more data

Purity By TLC

≥98% ; refer to CoA for more data

Melting point

200°C-206°C

Solubility test

Clear colorless solution at 10mg/ml of Methanol

Chemical identification

Names and identifiers

Synonyms

Aspergillin
IUPAC name : (3R,6S,10aR)-6-hydroxy-3-(hydroxymethyl)-2-methyl-2,3,6,10-tetrahydro-5aH-3,10a-epidithiopyrazino[1,2-a]indole-1,4-dione
IUPAC name : Gliotoxin

RTECS KB4725000

Description

Gliotoxin is a fungal antibiotic mycotoxin with antiphagycytic and immunomodulatory activities.

Gliotoxin is an antibiotic that is toxic to higher animals as well as to animal and plant pathogens and that is produced by various fungi (as of the genera Gliocladium, Aspergillus, andPenicillium)

InChl Key

FIVPIPIDMRVLAY-RBJBARPLSA-N

Canonical SMILES

CN1C(=O)C23CC4=CC=CC(C4N2C(=O)C1(SS3)CO)O

Isomeric SMILES

CN1C(=O)[C@]23CC4=CC=C[C@@H]([C@H]4N2C(=O)[C@]1(SS3)CO)O

Further Information

Solubility ( literature )

DMSO, Methanol, Ethanol, Ethyl acetate, Petrol-ether, Dichloromethane. Water insoluble

Compound Classification

Chemical class:

Indole mycotoxin

Bioactivity class:

Immunomodulator

Storage, handling

Store in a freezer upon arrival, at -10°C to -25°C

Hygroscopic substance.

Protect from moisture

Protect from light !

Avoid exposing to strong direct light.

Retest time

3 Years

Applications

Gliotoxin blocks the thiol groups in the membranes . Gliotoxin induces apoptotsis in macrophages and thymocytes. Gliotoxin induces Ca2+ release from intact rat liver mitochondria.

Disclaimer

For Research use only

Not for Human or Drug use

Not extracted from humans or animals

Refer to MSDS for further safety and handling instructions

Composition

Ingredient type

Fermentek product

Special Info

Available since

2008