Immunomodulators are bio-active agents, which suppress, weaken or alter the activity of the immune system. This may consequently weaken inflammatory responses. Immunomodulators (immunosuppreessors) are most often used in organ transplantation to prevent rejection of an implant.

Autoimmune diseases are situations, where the immune system attacks one's own cells, tissues and organs, erroneously recognizing them as alien factors.
Immunomodulators may be used to cure autoimmune deseases.

Ascomycin

Ascomycin
Molecular Formula
C43H69NO12
M.W.
792.01
CAS number
104987-12-4
Source
Streptomyces hygroscopicus subsp. ascomyceticus
Fermentek product Code
ASC-001
Brand/grade
For research
Appearance
White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
159°C-164°C
Solubility test
Ascomycin gives clear colorless solution at 10mg/ml Ethyl Acetate or 10mg/ml DMSO
Names and identifiers

 Synonyms

  • Immunomycin
  • FK520

RTECS KD4185000

EU number
435-850-5
Description

Ascomycin, also known as FK520, is a potent immunosuppressant.

Ascomycin inhibits allogenic T-lymphocyte proliferation.

InChl Key
ZDQSOHOQTUFQEM-PKUCKEGBSA-N
Canonical SMILES
CCC1C=C(CC(CC(C2C(CC(C(O2)(C(=O)C(=O)N3CCCCC3C(=O)OC(C(C(CC1=O)O)C)C(=CC4CCC(C(C4)OC)O)C)O)C)OC)OC)C)C
Isomeric SMILES
CC[C@@H]1/C=C(\C[C@@H](C[C@@H]([C@@H]2[C@H](C[C@H]([C@@](O2)(C(=O)C(=O)N3CCCC[C@H]3C(=O)O[C@@H]([C@@H]([C@H](CC1=O)O)C)/C(=C/[C@@H]4CC[C@H]([C@@H](C4)OC)O)/C)O)C)OC)OC)C)/C
Solubility ( literature )

DMSO, Methanol, Ethanol, EtOAc (Ethyl Acetate)

Compound Classification
  • macrolide
  • immunosuppressant
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Hygroscopic substance.
Protect from moisture
Avoid exposing to strong direct light.
Retest time
3 Years
Applications

Ascomycin is used in the research of immunological phenomena, such as organs transplantation, allergy, and the like. To our best knowledge, Ascomycin is neither used nor approved for clinical use of any kind, although related or similar compounds might serve as drug components. Specifically, Ascomycin from Fermentek is has no pharmacological use whatsoever. It is only offered for research, to universities and other research embodiments, to be used by qualified scientists only.

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Shipped at ambient temperature
Transport safety: Not Dangerous Goods; Not Regulated
Available since
Title
Transport information
Value
Not hazardous for transport
Title
Cancelled CAS numbers
Value
11011-38-4 ; 126340-36-1 ; 133876-12-7 ; 136457-58-4 ; 137767-75-0 ; 148400-02-6 ; 159430-76-9
Signal to sort
A