Nonactin
Molecular Formula
C40H64O12
M.W.
736.93
CAS number
6833-84-7
Source
Streptomyces griseus var griseus
Fermentek product Code
NON-001
Brand/grade
For research
Appearance
White needle-like crystals.
Purity by HPLC
≥98% ; refer to CoA for more data
Melting point
145°C-146°C
Crystallinity
Crystalline
Solubility test
Clear colorless solution at 10mg/ml Dichloromethane or 10mg/ml DMSO


Names and identifiers
  • Ammonium Ionophore.
  • Werramycin-A.
  • Polynactin

RTECS: RH1685000

EU number
229-911-3
Description

Nonactin from Streptomyces Griseus: a mixture of the two homolog macrotetrolide antibiotics: Nonactin, Monactin. Nonactin is not less than 80%, ballanced by Monactin only. The mixture does not contain any other natcins, such as Dinactin, Trinactin, Tetranactin. Nonactin batches released since May 2010 are better than 95% Nonactin by NMR; detailed information is available on request.

InChl Key
RMIXHJPMNBXMBU-QIIXEHPYSA-N
Canonical SMILES
CC1CC2CCC(O2)C(C(=O)OC(CC3CCC(O3)C(C(=O)OC(CC4CCC(O4)C(C(=O)OC(CC5CCC(O5)C(C(=O)O1)C)C)C)C)C)C)C
Isomeric SMILES
C[C@@H]1C[C@H]2CC[C@H](O2)[C@@H](C(=O)O[C@H](C[C@@H]3CC[C@@H](O3)[C@H](C(=O)O[C@@H](C[C@H]4CC[C@H](O4)[C@@H](C(=O)O[C@H](C[C@@H]5CC[C@@H](O5)[C@H](C(=O)O1)C)C)C)C)C)C)C
Solubility ( literature )

soluble in Methanol, Dichloromethane, Ethyl Acetate, DMSO.

Insoluble in water

Storage, handling
Refrigerate upon arrival, at +2°C to +8°C
Hygroscopic substance.
Protect from moisture
Open carefully.
Other vendors may recommend higher temperatures for storage.
Applications

Nonactin has an inhibitory effects on the P170 glycoprotein-mediated efflux of chemotherapeutic agents in multiple-drug-resistant cancer cells.

Nonactin, a natural mixture of macrotetrolides, was used in agriculture under the name trade POLYNACTIN. Nonactin has been reported to specifically inhibit the processing of cytoplasmic precursor proteins destined for the mitochondria.

Nonactin is used in urea and ammonium specific electrodes.

Disclaimer
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Not hazardous for transport
Fermentek Product Category
Signal to sort
N