K252a

Molecular Formula

C27H21N3O5

M.W.

467.47

CAS number

99533-80-9

Details

Source

Nocardiopsis sp

Fermentek product Code

K2A-001

Brand/grade

For research

Specifications

Appearance

White to pale yellow powder

Purity by HPLC

≥98% ; refer to CoA for more data

Purity By TLC

≥98% ; refer to CoA for more data

Melting point

255°C-270°C

Solubility test

Clear colorless to slight yellow solution at 50mg/ml of DMSO

Chemical identification

Names and identifiers

RTECS NZ0550000

EU number

640-127-4

Description

K252a: Cell permeable protein kinase inhibitor

InChl Key

KOZFSFOOLUUIGY-IYYJOCMQSA-N

Canonical SMILES

CC12C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)(C(=O)OC)O

Isomeric SMILES

C[C@]12[C@@](C[C@H](O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)(C(=O)OC)O

Further Information

Solubility ( literature )

Readily soluble in chloroform, acetonitrile, acetone, dioxane, tetrahydrofuran, pyridine;soluble in ethanol, methanol, 1-propanol, ethyl acetate and n-butanol; insoluble in water, 2-propanol

Compound Classification

indolocarbazole alkaloid
PK inhibitor

Storage, handling

Store in a freezer upon arrival, at -10°C to -25°C

Protect from moisture

Protect from light !

Use the original container to store the product.

Keep the lid tightly closed.

Retest time

3 Years

Applications

K252a is a highly potent cell permeable inhibitor of CaM kinase and phosphorylase kinase . At high concentrations it also inhibitors of serine/threonine protein kinases. K252a inhibits tyrosine phosphorylation of Trk A induced by NGF K252a is reported to promote myogenic differentiation in C2 mouse myoblasts

Disclaimer

For Research use only

Not for Human or Drug use

Not extracted from humans or animals

Refer to MSDS for further safety and handling instructions

Composition

Ingredient type

Fermentek product

Other Fields

Title

Deleted CAS Numbers

Value